Gastric secretory response to iron therapy.

The relationship of anaemia to gastric secretion more than 15 years after vagotomy and gastro-enterostomy

“…Because it might be argued that any secretory changes we found in our anaemic patients were due to the anaemia and not the cause of it, we repeated our secretory tests following correction of the iron deficiency and were able to confirm the findings of Stone (1968) that secretion of both acid and pepsin rose significantly after correction of the anaemia. However, even this increased secretory response was far lower than that found in our non-anaemic group.…”

The Effect of Iron Deficiency on the Tissues

“…There seems to come a stage where the changes become irreversible and may become progressive despite treatment. Stone [1968] has carried out similar gastric studies and shown that there can not only be a recovery of acid secretion when iron deficiency anaemia is treated but also a recovery of pepsin secre tion and possibly an increase in the secretion of intrinsic factor. Cyto chrome oxidase activity and succinate dehydrogenase activity in the gastric mucosa has shown no correlation whatsoever with acid or pepsin secretion.…”

Nutritional Supplements in the Ambulatory Geriatric Population

“…Atrophic gastritis and achlorhydria are common consequences of iron deficiency, and are only reversible if treated before the age of 30 years (Jacobs et al 1966;Stone 1968): after that, the effects are permanent. One intriguing question then, is how much of the low cyanocobalamin levels in the elderly is the consequence of achlorhydria from iron deficiency at a much earlier age?…”