Gastric stromal tumors in children

Haider, Naveed; Kader, Masih; Dermott, Mc; Devaney, D.; Corbally, Martin; Fitzgerald, Ray

doi:10.1002/pbc.10387

Cited by 20 publications

(13 citation statements)

References 9 publications

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“…A considerable number of articles describing children and adolescents with sporadic GIST have been published 36–69. We have identified 113 children below the age of 21 years with sporadic GIST forming the basis of the present review.…”

Section: Sporadic Pediatric Gistmentioning

confidence: 99%

Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature

Benesch

Wardelmann

Ferrari

et al. 2009

Pediatric Blood & Cancer

113

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Standards for the management of gastrointestinal stromal tumors (GIST) in children do presently not exist. Thus a systematic review and summary of the current literature was conducted serving as a basis for the further development of optimal management strategies for childhood GIST within a cooperative network. Presently 21 cases with familial GIST, and more than 100 pediatric cases each with Carney triad or sporadic GIST have been published so far. An international prospective registration based on national registries has recently started to acquire more clinical and molecular data and to develop appropriate management strategies for children and adolescents with GIST.

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Section: Sporadic Pediatric Gistmentioning

confidence: 99%

Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature

Benesch

Wardelmann

Ferrari

et al. 2009

Pediatric Blood & Cancer

113

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“…Only 25 children less than 15 years old including our case have been reported in the literature in English [3,4,[6][7][8][9][10][11][12][13][14][15][16]. Table 1 summarizes the clinical characteristics and compares GIST in adults and children.…”

Section: Discussionmentioning

confidence: 87%

“…GIST typically occur in the over 40 age group and are rare in children [2]. They have malignant potential, but their behavior has been difficult to predict [3,4]. Furthermore, the clinical characteristics of GIST in children and differences between adult and child cases are not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal stromal tumor in a child and review of the literature

et al. 2005

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Gastrointestinal stromal tumors (GIST) are c-KIT positive neoplasm that occur predominantly in adults. A 13-year-old boy who presented with massive gastrointestinal hemorrhage was subsequently diagnosed with GIST of the stomach. The tumor originated from the lesser curvature with a narrow base and no infiltration into surrounding organs. Two metastatic lesions in the liver were also found. Total excision of the gastric lesion was performed followed by adjuvant imatinib mesylate chemotherapy. He has had no signs of recurrence during 8 months of follow-up. GIST in children are rare and their behavior is notoriously difficult to predict. We report our experience and review the literature.

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“…However, they occur rarely in children and young adults, and reports in the pediatric literature consist of single case reports and a small series [1][2][3][4][5][6][7]. Classification as a GIST requires tumor expression of the KIT protein detected by immunohistochemical assays for CD117 antigen.…”

Section: Discussionmentioning

confidence: 99%