Gastric troubles in Iran: The role of social and economic factors in <i>Helicobacter pylori</i> infection

Zandian, Hamed; Moghadam, Telma Zahirian; Pourfarzi, Farhad; Malekzadeh, Reza; Rezaei, Satar; Ghorbani, S.

doi:10.34172/hpp.2023.15

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Hence, low socioeconomic status in developing countries can be identified as a risk factor for increased transmission of H. pylori as living in crowded conditions may facilitate intrafamilial transmission [ 13 , 14 ]. The results of a very recent study by Zandian et al, on H. pylori -infected patients in Iran, further supported that poor socioeconomic status and low education levels were important risk factors for increased rates of H. pylori infection transmission [ 15 ].…”

Section: Introductionmentioning

confidence: 86%

Addressing Challenges in Standardizing Helicobacter pylori Treatment Protocols: Importance and Review

Kaur,

Leon Guevara

2024

Cureus

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Helicobacter pylori, one of the top carcinogens, is associated with most cases of gastric cancer-related deaths worldwide. Over the past two decades, the rising rates of antibiotic resistance in the bacterium have reduced the efficacy of conventional antibiotic-based treatments. This underscores the urgency for continued research and novel treatment approaches. Establishing a worldwide accepted physician guideline for antibiotic prescription is crucial to combat antibiotic resistance and improve H. pylori infection management. Therefore, it is important to address the challenges that complicate the establishment of a universally accepted treatment protocol to prescribe an antibiotic regimen to eradicate H. pylori. The answers to the questions of why conventional standard triple therapy remains a first-line treatment choice despite its low efficacy, and how different factors affect therapy choice, are needed to identify these challenges. Hence, this review addresses concerns related to H. pylori treatment choice, role of antibiotic resistance and patient compliance in treatment outcomes, first-line vs. second-line therapy options, and methods for enhancing existing treatment methods. We also present a chart to aid antibiotic treatment prescription, which may support physician guidelines in this aspect. Eradication of H. pylori and patient adherence is paramount in overcoming antibiotic resistance in the bacterium, and our chart summarizes key considerations and suggests novel approaches to achieve this goal.

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Section: Introductionmentioning

confidence: 86%

Addressing Challenges in Standardizing Helicobacter pylori Treatment Protocols: Importance and Review

Kaur,

Leon Guevara

2024

Cureus

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An Update on Eradication of Helicobacter Pylori in Iran: A Review

Ebrahimi,

Tirgar Fakheri,

Aeeni

et al. 2024

Middle East J Dig Dis

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Background: Helicobacter pylori, the most prevalent infection in the world, has great importance due to being related to peptic ulcer disease, gastric metaplasia, dysplasia, and even gastric adenocarcinoma or mucosa-associated lymphoid tissue (MALT) lymphoma. The standard H. pylori eradication regimen is based on antibiotic susceptibility testing. If susceptibility testing is not available, a standard treatment regimen will be recommended based on records of H. pylori resistance rates to antibiotics in a region or locally proven highly effective regimens (equal to or higher than 90% eradication rate). The aim of this review was to define suitable recommendations for local treatment in different cities of Iran. Methods: This review article consists of randomized controlled trials related to H. pylori eradication in Iran. Data including the kind of therapy, number of patients and per-protocol H. pylori eradication rates were recorded in data gathering forms. Data search was conducted in PubMed and Google Scholar databases from 2018 to December 2023. Results: According to our review of Iranian articles regarding first-line H. pylori eradication regimens, these treatment protocols could be recommended: Bismuth-clarithromycin quadruple therapy in Ardabil, bismuth-clarithromycin quadruple therapy with probiotics in Birjand, standard triple therapy in Ilam, bismuth quadruple therapy or bismuth triple therapy or concomitant regimen in Sari, sequential therapy in Tehran and bismuth quadruple therapy in Yazd. These regimes can be extended to other regions that have a similar situation. According to the reports of Iranian researchers, a quinolone-containing regimen (levofloxacin preferred) is recommended for second-line eradication therapy. Conclusion: Various H. pylori eradication regimens can be used as first-line therapy; however, choices for second-line therapy are limited. We recommend the quinolone-containing regimens as the preferred second-line therapy.

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Gastric troubles in Iran: The role of social and economic factors in Helicobacter pylori infection

Cited by 2 publications

References 38 publications

Addressing Challenges in Standardizing Helicobacter pylori Treatment Protocols: Importance and Review

Addressing Challenges in Standardizing Helicobacter pylori Treatment Protocols: Importance and Review

An Update on Eradication of Helicobacter Pylori in Iran: A Review

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