Gastric Ulcer, Duodenal Ulcer and Gastric Carcinoma: A Case‐control Study of Certain Social and Environmental Factors

Gillies, Margaret; Skyring, A. P.

doi:10.5694/j.1326-5377.1968.tb83470.x

Cited by 76 publications

(23 citation statements)

References 31 publications

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“…Forty-seven studies, comprising 2,345,540 patients and over 13,500 events reported the association between anti-inflammatory drug use and the risk of GC, met all of the selection criteria and were included in our meta-analysis (Figure 1) 10-15, 19, 21-29, 33-63. Of these enrolled articles, nine were RCT studies 12, 23, 27, 29, 38, 44, 48, 52, 61, fifteen were cohort studies 15, 24, 26, 28, 33-37, 45, 46, 58-60, 62, and the remaining twenty-three were case-control studies 10, 11, 13, 14, 21, 22, 24, 25, 39-43, 47, 49-51, 53, 54, 56, 57, 63.…”

Section: Resultsmentioning

confidence: 99%

“…It is reported that PGE2 may modulate various immune responses, increase cells' longevity via inhibition of apoptosis, and stimulate cancer cell proliferation 7-9. Since 1970s, a host of prior large epidemiologic studies and meta-analyses strongly support a protective association between aspirin/NSAIDs ingestion and gastric adenocarcinomas 10-18. However, several studies argue that using aspirin or other NSAIDs does not lower risk of GC 19-21.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis

Kong¹,

Liu³

et al. 2016

J. Cancer

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Gastric cancer has high incidence and fatality rates, making chemoprevention agents necessary. There is an ongoing debate about aspirin/nonsteroidal anti-inflammatory drugs (NSAIDs) use can significant reduce the risk of GC. We conducted a meta-analysis of existing studies evaluating the association of anti-inflammatory drug and GC. We performed a systematic literature search of PubMed, Web of Science, Embase, OVID, Cochrane Library and Clincialtrials.gov up to August 31, 2015. Either a fixed-effects or a random-effects model using was based on the result of homogeneity analysis. Subgroup, sensitivity, meta-regression, and publication bias analyses were evaluated. Forty-seven studies were finally included in this meta-analysis. The overall GC risk reduction benefit associated with anti-inflammatory drug use represented an RR of 0.78 (95% CI 0.71 to 0.85) and an adjusted RR of 0.74 (95% CI 0.71 to 0.77). Besides, the prevention benefit of aspirin/NSAIDs ingestion appeared to be confined to those patients with regiment of short or middle-term (≤5 years), high-frequency (>30 times per month) and low dose (<200 mg per day). Further, our data also suggest that COX-2 inhibitors use is a more effective approach in GC prevention (RR, 0.45; 95% CI, 0.29-0.70). In this meta-analysis, our finding support short or middle-term (≤5 years), high-frequency (>30 times per month) and low dose (<200 mg per day) aspirin/NSAIDs intake is a well method for GC prevention and also confirm the inverse association between aspirin/NSAIDs use and GC risk. Additionally, selective COX-2 inhibitors use probably a more effective approach to reduce GC risk.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis

Kong¹,

Liu³

et al. 2016

J. Cancer

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“…women IDuodenal (n= 117) 3-4 (15 to 7-9) 3-0 (1-4 to 7-1) Gastric (n=52) 3-1 (0-9 to 11-0) 15-0 (1-9 to 328-0) Men Duodenal (n=86) [2][3][4][5][6][7][8] (1 1 to 7-4) [3][4][5] (1-3 to 10-0) Both 2-9(1-4to6-2) 5-1(2-1 to 14-0) Gastric (n=61) 1-4 (0 5 to 4-1) 1-6 (0-5 to 5 1) Women Duodenal (n= 31) 5 9 (1 1 to 46 0) 2-4 (0 5 to I 10) 5(1) 15 (8) associated with use of aspirin, although risks were slightly lower for those who had taken the drug within the preceding 24 hours or week. Patients with bleeding ulcers were more likely to have taken aspirin whether those presenting with indigestion (n= 106) or those who did not have indigestion (n= 124) were considered: 20 with indigestion and 30 without indigestion had taken aspirin.…”

Section: Resultsmentioning

confidence: 99%

Aspirin and bleeding peptic ulcers in the elderly.

Faulkner¹,

Prichard²,

Somerville³

et al. 1988

BMJ

108

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A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as nonaspirin, non-steroidal anti-inflammatory drugs. The intake of analgesics in 230 patients with bleeding ulcers aged 60 and over and in hospital and community controls matched for age and sex was examined. Those who had taken aspirin were between two and three times more likely to be admitted to hospital with bleeding ulcers. This increased risk was not accounted for by aspirin taken for indigestion or by concurrent use of non-aspirin, non-steroidal anti-inflammatory drugs. A similar effect was not seen for paracetamol.When aspirin and other non-steroidal antiinflammatory drugs were considered together the overall risk attributed to the drugs suggested that these drugs may be responsible for over a third of admissions for bleeding peptic ulcers in the elderly. IntroductionWe have found that bleeding from gastric or duodenal ulcers in patients aged 60 and over is strongly associated with the use of non-aspirin, non-steroidal anti-inflammatory drugs.' Aspirin has also been associ-

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“…Aspirin abuse is associated with chronic gastric ulcer, particularly in females (Gillies and Skyring, 1968;Chapman and Duggan, 1969;Alp, Hislop, and Kerr Grant, 1970), with bleeding gastric ulcer (Duggan, 1970), and with analgesic nephropathy in association with gastric ulcer (Dawborn, Fairley, Kincaid-Smith, and King, 1966;Gault, Rudwal, Engles, and Dossetor, 1968;Fellner and Tuttle, 1969;Duggan, 1971).…”

Section: Discussionmentioning

confidence: 99%

Aspirin ingestion and perforated peptic ulcer

Jm¹

1972

Gut

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SUMMARY The results of a prospective inquiry into the aspirin taking habits of a consecutive series of 118 patients admitted to a large general hospital with acute perforation of peptic ulcer are presented. The series shows considerable increase in the proportion of females to males and of ulcers of the stomach compared to pyloro-duodenal perforations in contrast to British experience. Forty-five per cent of males and 75 % of females were accustomed to taking at least two doses of an aspirin preparation weekly and most of the women took at least two doses daily. There was a highly significant association of heavy aspirin intake with ulcers of the stomach. The data support the theory that aspirin abuse is a cause of chronic gastric ulcer. It also supports the hypothesis that aspirin is the environmental factor responsible for the epidemic of gastric ulcers in middle-aged women in eastern Australia.

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Gastric Ulcer, Duodenal Ulcer and Gastric Carcinoma: A Case‐control Study of Certain Social and Environmental Factors

Cited by 76 publications

References 31 publications

The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis

The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis

Aspirin and bleeding peptic ulcers in the elderly.

Aspirin ingestion and perforated peptic ulcer

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