Gastric ulcer healing activity against acidified ethanol-induced gastric ulcer and gastroprotective mechanisms of Zingiber simaoense rhizome ethanol extract in rats

Laprasert, Chanyanuch; Kunanusorn, Puongtip; Panthong, Ampai; Khonsung, Parirat; Chiranthanut, Natthakarn; Rujjanawate, Chaiyong

doi:10.4103/pm.pm_389_19

Cited by 4 publications

(1 citation statement)

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“…However, these drugs cause an increase in acidity after a short period of treatment, resulting in a relapse of the ulcer. 9 According to, 10 kidney damage, hip fractures, pneumonia, and gastric cancer have been observed after administration of proton pump inhibitors. An effective and inexpensive plant-based anti-ulcer drug, therefore, remains a medical challenge.…”

Section: Introductionmentioning

confidence: 99%

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Belmamoun,

Ammam,

Mhamdia

et al. 2023

Ind. J. Pharm. Edu. Res

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Background: Our study evaluated the effect of Chrysanthemum coronarium L. (CC) leaves on ethanol-induced acute gastric ulcers in Wistar rats. Materials and Methods: The organic extract of CC was obtained by Soxhlet extraction with methanol and then divided into two dose groups: 250 mg/kg and 500 mg/kg. Omeprazole was used as a positive control at 20 mg/ kg. Our extract was subjected to the separation of bioactive compounds by High-Performance Liquid Chromatography (HPLC). Lethality tests (LD 50 ) were carried out using standard procedures. Gastric protection was assessed by measuring gastric juice volume, total acidity, and free acidity. Gastric mucosal damage was assessed by histopathological examination. Results: Chromatographic analysis of the Methanolic Extract of Chrysanthemum coronarium L. (MECC) identified the presence of 19 phenolic compounds, representing 46.47% of the total sample. The dominant components were o-coumaric acid (9.55%), chlorogenic acid (6%), myricetin (4.19%), and benzoic acid (2.87%). Oral LD 50 value was more than 5000 mg/kg in rat. In the present study, the methanolic extract of CC decreased total and free gastric acidity (53.80±7.038 and 17.8±2.375 respectively) for the 500 mg/kg dose and (60.40±4.490 and 24.8±1.855 respectively) for the 250 mg/kg dose. Omeprazole also decreased free and total gastric acidity (54.40±3.092 and 20±2.449 respectively), compared with the ethanol groups (19.40±2.909 and 4.4±0.678 respectively). In the histological study, we found that the gastric mucosal barrier could be significantly strengthened when the rats were pretreated with 500 mg/kg of the MECC and showed almost normal histology compared with the ethanol-ulcerated groups. Conclusion: Based on the present results, we can conclude that CC leaves could be a promising food for the protection of the gastric mucosa against ethanol-induced lesions.

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Section: Introductionmentioning

confidence: 99%