Gastric Ulcer Healing – Role of Serum Response Factor

Chai, Jianyuan

doi:10.5772/17410

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…Gastric ulcer is due to an imbalance between protective and aggressive factors in the stomach, which is caused by the infection of Helicobacter pylori 29 , non-steroid antiinflammatory drugs, stress condition, and alcohol consumption 30,31 . Microscopic and pharmacognostic standardization will help in the identification and authentication of the genuine plant materials, the presence of starch grains, Lignified tissues, cellulose, proteins, and oil globules, as shown in tables 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

GC-MS, FTIR and Antiulcer Screening of Aqueous Seed Extract and Oil of Nigella sativa in Wistar Rats

Bruce

Nwafor

Omoirri

et al. 2021

J. Drug Delivery Ther.

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Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined. The seeds were extracted using two methods digestion and hydro-distillation. The acute toxicity, phytochemical constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS analysis of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochemical studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the positive control (Famotidine). The FTIR analysis identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alcohol, while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-methyl ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally. Keywords: Nigella sativa, Black seed, Pharmacognostic, Phytochemical, Acute toxicity (LD50), Antiulcer.

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Section: Discussionmentioning

confidence: 99%

GC-MS, FTIR and Antiulcer Screening of Aqueous Seed Extract and Oil of Nigella sativa in Wistar Rats

Bruce

Nwafor

Omoirri

et al. 2021

J. Drug Delivery Ther.

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“…SRF regulates numerous genes that are involved in cellular responses to mitogenic stimuli as well as cellular stress [37][38][39]. These genes fall into many diversified categories, including immediate early genes (FOS, EGR1, etc.…”

Section: Hypoxia Activates Srfmentioning

confidence: 99%

Roles of SRF in Endothelial Cells During Hypoxia

Chai¹

2013

Research Directions in Tumor Angiogenesis

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“…This heavy lifting is done by the digestive system. According to the World Health Organization (WHO), more than 6 million people on earth die of various digestive disorders every year [1], only second to heart disease (~7 million). Therefore, it is absolutely vital to understand how this system works and to take good care of it.…”

Section: Introductionmentioning

confidence: 99%