Gastric ulcerations in COVID-19: an ominous sign?

Deb, Anasua; Thongtan, Thanita; Costilla, Vanessa

doi:10.1136/bcr-2021-244059

Cited by 9 publications

(20 citation statements)

References 3 publications

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“…It was suspected that the occurrence of ulcers was directly related to SARS-CoV-2 infection, and was also related to the disease degree of the patients ( Lin et al, 2020 ). Deb et al (2021) found that three COVID-19 patients had large, deep, and more than one non-hemorrhagic gastric ulcer, all resulting in death due to poor prognosis. Taherifard et al (2022) reviewed a case of gastric ulcer induced by cytomegalovirus(CMV) after SARS-CoV-2 infection, and listed a number of similar cases, which were suspected to be further caused by the immune disorder of patients after SARS-CoV-2 infection.…”

Section: Gastrointestinal Diseases Caused By Sars-cov-2 Infectionmentioning

confidence: 99%

SARS-CoV-2 and gastrointestinal diseases

2023

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BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the novel coronavirus disease (COVID-19) pandemic, which has caused serious challenges for public health systems worldwide.Literature reviewSARS-CoV-2 invades not only the respiratory system, but also the digestive system, causing a variety of gastrointestinal diseases.SignificanceUnderstanding the gastrointestinal diseases caused by SARS-CoV-2, and the damage mechanisms of SARS-CoV-2 to the gastrointestinal tracts and gastrointestinal glands are crucial to treating the gastrointestinal diseases caused by SARS-CoV-2.ConclusionThis review summarizes the gastrointestinal diseases caused by SARS-CoV-2, including gastrointestinal inflammatory disorders, gastrointestinal ulcer diseases, gastrointestinal bleeding, and gastrointestinal thrombotic diseases, etc. Furthermore, the mechanisms of gastrointestinal injury induced by SARS-COV-2 were analyzed and summarized, and the suggestions for drug prevention and treatment were put forward for the reference of clinical workers.

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Section: Gastrointestinal Diseases Caused By Sars-cov-2 Infectionmentioning

confidence: 99%

SARS-CoV-2 and gastrointestinal diseases

2023

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“…The endoscopic appearances of gastric mucosa include the presence of diffuse, multifocal, punctate mucosal hemorrhage; dark-red discoloration of the mucosa; multiple easily-bleeding irregular-shaped ulcers; and rarely ischemic changes. 14,[21][22][23][24] Microscopic findings ranged from nonspecific alterations, including lamina propria (LP) edema, dilated and congested capillaries, and an inflammatory infiltrate comprised of lymphocytes, plasma cells, and macrophages, to ischemic mucosal changes with scattered capillary microthrombi (Fig. 1A).…”

Section: Stomachmentioning

confidence: 99%

The Spectrum of Digestive Tract Histopathologic Findings in the Setting of Severe Acute Respiratory Syndrome Coronavirus-2 Infection: What Pathologists Need to Know

Al-Zaidi

2023

Advances in Anatomic Pathology

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Although the novel severe acute respiratory syndrome coronavirus-2 is known primarily to affect the respiratory system, current evidence supports its capability to infect and induce gastrointestinal tract injury. Data describing the histopathologic alterations of the digestive system in patients infected with severe acute respiratory syndrome coronavirus-2 are becoming more detailed, as the number of studies is increasing and the quality of our insight into the infection and the histopathologic findings is improving. This review highlights the range of pathologic findings that could be observed in gastrointestinal specimens from patients infected with coronavirus disease 2019 and the potential underlying pathogenetic mechanisms of this disease.

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“…При этом в слизистой пищевода, желудка и кишечника развивается воспаление различной степени выраженности [9]. Deb A. et al,2021, характеризуют обнаруженные при проведении эндоскопии изъязвления желудка, связанные с COVID-19, как большие, глубокие и не поддающиеся традиционной эндоскопической терапии, что по мнению авторов связано с наличием рыхлых некротических тканей, окружающих изъязвления [15].…”

Section: патогенез эрозивно-язвенных поражений желудка и 12-перстной ...unclassified

“…Это свидетельствует о высокой частоте симптомов, которые обусловлены поражением органов пищеварения вирусом SARS-CoV-2, а также обострением хронической гастроэнтерологической патологии на фоне новой коронавирусной инфекции и ее агрессивной терапии. При этом наличие и тяжесть хронических заболеваний ЖКТ могут существенно повлиять на клиническое течение COVID-19 [4,5,12,15]. Клиническая картина эрозивно-язвенного поражения желудка и 12-перстной кишки при COVID-19 зависит от локализации патологического процесса, наличия коморбидной патологии, возраста больного, развития осложнений [2,4].…”

Section: клиническая картинаunclassified

“…Диспепсический синдром возникает независимо от локализации язвенного дефекта и проявляется в виде: изжоги (наиболее частый и характерный симптом, обусловленный желудочно-пищеводным рефлюксом и раздражением слизистой оболочки пищевода желудочным содержимым); отрыжки (воздухом или пищей); тошноты (наиболее характерна для медиогастральных язв); рвоты (связана с повышением тонуса блуждающего нерва, усилением моторики желудка и желудочной гиперсекрецией, возникает на «высоте» боли и приносит облегчение). Нарушения стула чаще проявляются в виде запоров, что может быть связано с диетой, снижением физической активности, приёмом антацидов, хотя у больных COVID-19 нередко доминирует диарея [15,18].…”

Section: клиническая картинаunclassified

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Extrapulmonary manifestations of SARS-CoV-2: a new coronavirus infectionas an aggravating factor in peptic ulcer disease

Левитан

Скворцов

Eremenko

2022

jour

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The global pandemic of the new coronavirus infection (COVID-19) has become an extreme challenge for the health care of the whole world since 2020.The main target of the SARS-CoV-2 virus is the lungs, but at the same time, more and more evidence is accumulating that the new coronavirus can also aﬀ ect other organs and systems, such as the heart, blood vessels, kidneys, intestines, and brain.Thus, adequate management of a coronavirus patient means not only the therapy of viral pneumonia, but also the timely diagnosis and treatment of damage to other organs.The analysis of predictor factors of severe course and fatal outcome in COVID-19 indicates the aggravating role of comorbid pathology, such as cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, chronic gastrointestinal diseases. Therefore, in addition to measures to prevent infection with SARS-CoV-2, measures should also be taken to control the comorbid conditions present in the patient.ACE2 receptors, which the virus uses to penetrate human cells, can also be expressed in the esophagus, stomach, small and large intestines, liver and pancreas. This makes the frequency of gastroenterological symptoms in COVID-19 high, which is caused both by the defeat of the digestive organs by the coronavirus itself and by the exacerbation of chronic gastrointestinal diseases against the background of infection and its aggressive therapy. At the same time, the presence and severity of digestive diseases signiﬁ cantly aﬀect the clinical course of COVID-19.This article is devoted to the pathogenesis, clinical picture, approaches to the diagnosis and therapy of erosive ulcerative lesions of the stomach and duodenum against the background of a new coronavirus infection.

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Gastric ulcerations in COVID-19: an ominous sign?

Cited by 9 publications

References 3 publications

SARS-CoV-2 and gastrointestinal diseases

SARS-CoV-2 and gastrointestinal diseases

The Spectrum of Digestive Tract Histopathologic Findings in the Setting of Severe Acute Respiratory Syndrome Coronavirus-2 Infection: What Pathologists Need to Know

Extrapulmonary manifestations of SARS-CoV-2: a new coronavirus infectionas an aggravating factor in peptic ulcer disease

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