Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Wang, Zhen; Mo, Tang-Ming; Tian, Lei; Chen, Junqiang

doi:10.2147/ijgm.s335985

Cited by 16 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wang et al (2021) evaluated the effectiveness of combining gastrin-17 with CEA, CA12-5, and CA19-9 in the diagnosis of gastric cancer. The results showed a sensitivity of four indicators for diagnosing gastric cancer less than 25%, which suggests that they do not meet the necessary standards for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Gasenko¹,

Bogdanova²,

Sjomina

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

ObjectivesThe aim of the study was to determine the proportion of gastric cancer patients with decreased levels of pepsinogen and gastrin-17 in plasma, with the goal of providing indirect evidence of the sensitivity of these biomarkers when applied in a cancer screening setting. MethodsThe levels of pepsinogens I and II, gastrin-17, and Helicobacter pylori immunoglobulin antibodies in plasma samples of gastric cancer patients were evaluated using the GastroPanel test system (Biohit Oyj, Helsinki, Finland). A decreased level of the pepsinogen I/ II ratio was defined as less than three, while a decrease in gastrin-17 was defined as less than 1 pmol/L. Univariate analysis using non-parametric tests was used to investigate differences between normal and low concentrations of biomarkers. ResultsIn total, 481 plasma samples from patients (59.9% male) with a median age of 64 years (ranging from 27 to 88 years) were analyzed. Out of the 400 cases of gastric cancer (83.2% of the total), 182 were categorized as the intestinal type, 141 as the diffuse type, 60 as the mixed type, and 17 as indeterminate according to the Lauren classification system. The H. pylori immunoglobulin test was positive in 74.0% of the patients. Pepsinogen I/ II ratio was decreased in 32.4% (36.8% of the intestinal type); gastrin-17 in 12.3% (10.1% of the antral region) of all cases. ConclusionThe majority of gastric cancer patients had normal levels of pepsinogen and gastrin-17, suggesting that these biomarkers have limited application as screening tools in the Caucasian population. European

show abstract

Section: Discussionmentioning

confidence: 99%

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Gasenko¹,

Bogdanova²,

Sjomina

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Many clinical studies of gynecologic malignancies incorporated CA125 as a serum marker that indicates tumorigenesis and metastasis [ 16 , 17 ]. As an easily accessible clinical examination, CA125 also played a key role in the diagnosis of gastrointestinal malignant tumors [ 18 , 19 ]. Studies have shown that CA125 level was a predictive factor of peritoneal metastases in gastric cancer [ 20 , 21 ] and normalization of CA125 was relevant with better survival [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

et al. 2023

View full text Add to dashboard Cite

Background Carbohydrate antigen 125 (CA125) is elevated as a tumor marker in many carcinomas, but its association with gastrointestinal stromal tumor (GIST) has received less attention. This study intends to evaluate whether CA125 level can predict tumor progression and overall survival (OS) of GIST patients. Methods We retrospectively analyzed the clinical data and follow-up records of GIST patients who underwent surgical resection in Nanjing Drum Tower Hospital from August 2010 to December 2020. All patients were classified according to serum CA125 level. The relationship between CA125 and clinical outcomes was then examined. Results A total of 406 GIST patients were enrolled in this study, among which 46 patients had preoperative elevated serum CA125 level and 13 patients with high CA125 level both preoperative and postoperative were observed. Preoperative CA125 concentration was significantly related to rupture status, resection style, tumor site, tumor size, mitotic index, NIH risk grade and c-kit exons. According to Kaplan–Meier curve analysis, high expression of postoperative CA125 was significantly correlated with worse progression-free survival (PFS) and OS among patients with preoperative elevated CA125 level. Ultimately, Cox proportional regression model analysis revealed that increase of preoperative and concurrent postoperative CA125 concentration was an independent predictive factor for PFS. Conclusions The concurrent abnormality of serum CA125 before and after operation was an independent risk factor for GIST progression, suggesting its significance as a serum biomarker in the overall management of GIST patients.

show abstract

“…Studies in northeastern and southern China showed that the sensitivity of CEA in the diagnosis of GC was 49.6% and 34.78%, respectively, and that of CA19-9 was 49.6% and 52.61%, respectively. 31,32 We consider that the difference in sensitivity and predictive performance of TMs in different regions may be affected by diet. 33 The dietary habits of Northeast China and South China are different.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients

Zhang,

Yin,

Wang

et al. 2023

Cancer Control

View full text Add to dashboard Cite

Background Tumor markers (TMs) are important for the prognosis of gastric cancer (GC). However, the prognostic importance of the tumor marker index (TMI) based on GC-specific TMs for advanced gastric cancer (AGC) still needs to be further explored. Methods We retrospectively examined patients who underwent radical gastric cancer surgery between February 2014 and June 2016 at the Department of Gastroenterological Surgery, Affiliated Cancer Hospital, Harbin Medical University. The patients were divided into training and validation groups. TMI was determined as the geometric mean of the standard cancer antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels. Patient overall survival was assessed using the Kaplan–Meier method. Independent prognosis-associated risk factors were identified using Cox hazard regression models. A nomogram model incorporating TMI and clinicopathological factors was developed, and its performance was evaluated using a decision curve analysis, concordance index, and calibration plots. Results In the TMI training cohort, the cutoff value was set at .439, categorizing patients into TMI-High and TMI-Low groups. The 5-year survival rate in the TMI-Low group significantly surpassed that in the TMI-High group (78.2% vs 58.1% and 49.7 vs 41.6, P < .001). TMI emerged as an independent prognostic factor. The nomogram accurately predicted patient prognosis by using TMI and clinicopathological characteristics. Validation of the TMI in the independent cohort yielded satisfactory results. Conclusion The TMI constructed based on specific TMs associated with gastric cancer can offer a precise prognostic prediction for patients.

show abstract

Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Cited by 16 publications

References 31 publications

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients

Contact Info

Product

Resources

About