Gastrin activity along the gastrointestinal tracts of some ruminants and the donkey

Olowo-Okorun, M. O.

doi:10.1016/0016-6480(75)90058-1

Cited by 9 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22,23 As in other species, gastrin or gastrinlike activity has been detected in the equine pyloric and duodenal mucosae, and parental administration of pentagastrin in the horse has been shown to cause a dose-related increase in gastric secretion within the submaximal range of secretion. 15,24 Data from this study are reported on a body weight basis, as is conventional for some researchers, resulting in more standardized measurements that can be compared across different-sized animals. 15,25 Although it has been suggested that mucosal prostaglandin content is the protective factor, measuring gastric juice prostaglandin content rather than mucosal biopsy prostaglandin content may be preferred as an indicator of prostaglandin response.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Corn Oil Supplementation on Equine Gastric Fluid Acid, Sodium, and Prostaglandin E2 Content before and during Pentagastrin Infusion

Cargile¹,

Burrow²,

Kim³

et al. 2004

J Vet Int Med

View full text Add to dashboard Cite

The effect of corn oil (approximately 60% [wt/vol] linoleic acid) dietary supplementation on various components of equine gastric secretion was studied by use of a repeated-measures experimental design. Four healthy adult ponies were surgically fitted with gastric cannulas. The ponies were then fed a free-choice hay diet for 5 weeks, which was followed by 5 weeks of the same diet supplemented with 45 mL of corn oil daily. Gastric contents were analyzed under basal and pentagastrin-stimulated conditions once weekly during the latter 2 weeks on each diet. Gastric contents were collected at 30-minute intervals, and volume, hydrogen ion concentration, sodium content, and prostaglandin E2 (PGE2) content were measured. Data were analyzed by a linear fixed-effect modeling procedure. During the diet supplemented with corn oil, the ponies had, under basal and pentagastrin-stimulated conditions, significantly decreased acid output and significantly increased PGE2 and sodium outputs compared to those measured before corn oil supplementation. We conclude that corn oil supplementation may be an effective and inexpensive way to increase the protective properties of equine glandular gastric mucosa. This could be particularly helpful in reducing the chances of ulceration associated with nonsteroidal anti-inflammatory drug (NSAID) administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Corn Oil Supplementation on Equine Gastric Fluid Acid, Sodium, and Prostaglandin E2 Content before and during Pentagastrin Infusion

Cargile¹,

Burrow²,

Kim³

et al. 2004

J Vet Int Med

View full text Add to dashboard Cite

show abstract

“…Qualitatively, PG and HG-I have the same effects so that PG effect scan be regarded with some confidence as representative of gastrin's actions in the upper equine GI tract (Merritt 1998). The ultimate comparison, of course, would be with pure equine gastrin, which currently would require some effort to obtain (Olowo-Okorun 1975).…”

Section: Cannula Studiesmentioning

confidence: 99%

Normal equine gastroduodenal secretion and motility

Merritt

1999

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary This article represents an attempt to provide an overview of the current knowledge of equine gastroduodenal secretory and motor activity, with respect to howe these functions are controlled and interact First, the equine gastric mucosal anatomy is discussed in comparison with other monogastric species, with some attention directed at the large nonglandular portion in relation to its function, or lack thereof. Next, control of gastric acid secretion, as assessed by the collection of gastric contents from a cannula or continuous measurement of their changes in pH, is reviewed, pointing out that there appears to be a relatively unobstructed movement of contents between stomach and duodenum in the horse, which can have a strong influence on pH of the gastric contents in particular. Then, methods of evaluating gastroduodenal motility, including recording of myoelectrical activity and changes in intraluminal pressure, and transit of radiolabelled contents from stomach into duodenum, are discussed. Finally, the apparent influence of the gastroduodenal migrating motility complex (MMC) on the composition of fasting gastric contents is introduced to underscore the observation that reflux of duodenal contents into the stomach is probably a common occurrence in the horse, particularly during periods of MMC‐related cessation of antral motility.

show abstract

Serum immunoreactive gastrin activity in horses: Basal and postprandial values

Brown

Sonea

et al. 1987

Vet Res Commun

View full text Add to dashboard Cite

Using commercially available diagnostic reagents, serum immunoreactive gastrin activity was measured in five normal horses that were starved of food and water for 24 hours. Blood samples were taken every 15 minutes for two hours. The horses were then fed a pelleted diet for 15 minutes and samples were taken every 15 minutes for a further two hours. Three further samples were taken at hourly intervals. The total sampling period was seven hours. Basal immunoreactive gastrin activity was lower than that reported in other mammals, ranging from a mean of 7.0 pg/ml to 13.8 pg/ml. At 30, 60 and 75 minutes after feeding, mean gastrin immunoreactivity was significantly elevated at 17.4, 19.8 and 18.2 pg/ml respectively. A late significant elevation occurred also five hours after feeding reading 19.4 pg/ml. This low activity may reflect a lower concentration of serum gastrin in the horse than in other mammals, or the methods used in the study may have failed to detect equine serum gastrins.

show abstract

Gastrin activity along the gastrointestinal tracts of some ruminants and the donkey

Cited by 9 publications

References 6 publications

Effect of Dietary Corn Oil Supplementation on Equine Gastric Fluid Acid, Sodium, and Prostaglandin E2 Content before and during Pentagastrin Infusion

Effect of Dietary Corn Oil Supplementation on Equine Gastric Fluid Acid, Sodium, and Prostaglandin E2 Content before and during Pentagastrin Infusion

Normal equine gastroduodenal secretion and motility

Serum immunoreactive gastrin activity in horses: Basal and postprandial values

Contact Info

Product

Resources

About