Gastrin, Cholecystokinin, and Somatostatin in a Laboratory Experiment of Patients With Functional Dyspepsia

Jonsson, B.; Uvnäs‐Moberg, Kerstin; Theorell, Töres; Gotthard, R

doi:10.1097/00006842-199805000-00020

Cited by 32 publications

(22 citation statements)

References 25 publications

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“…21 We were unable to find differences in postprandial plasma CCK concentrations or gastric volumes (as a measure of gastric relaxation) in relation to the information about fat content. Our data indicate that CCK is not involved in exacerbation of symptoms by cognitive influences.…”

Section: Discussionmentioning

confidence: 68%

Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia

Feinle‐Bisset

Meier²,

Fried³

2003

Gut

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Background and aims: Dietary fat plays a role in the pathophysiology of symptoms in functional dyspepsia (FD). In healthy subjects, cognitive factors enhance postprandial fullness; in FD patients, attention increases gut perception. We hypothesised that the information given to patients about the fat content of a meal would affect dyspeptic symptoms. Methods: Fifteen FD patients were each studied on four occasions in a randomised double blind fashion. Over two days they ingested a high fat yoghurt (HF) and over the other two days a low fat yoghurt (LF). For each yoghurt, the patients received the correct information about its fat content on one day (HF-C, LF-C) and the opposite (wrong) information on the other day (HF-W, LF-W). Dyspeptic symptoms, plasma cholecystokinin (CCK) concentrations, and gastric volumes were evaluated. Results: Both the fat content and information about the fat content affected fullness and bloating scoresboth were higher after HF-C compared with LF-C, and LF-W compared with LF-C, with no differences between HF-C and HF-W. Nausea scores were higher after HF compared with LF, with no effect of the information about fat content. No differences between discomfort and pain scores were found between study conditions. Plasma CCK and gastric volumes were greater following HF compared with LF, with no effect of the information given to the patients. All differences are p,0.05. Conclusions: Cognitive factors contribute to symptom induction in FD. Low fat foods may also elicit symptoms if patients perceive foods as high in fat, while CCK and gastric volumes do not appear to be affected by cognitive factors.

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Section: Discussionmentioning

confidence: 68%

Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia

Feinle‐Bisset

Meier²,

Fried³

2003

Gut

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“…Several studies have investigated the role of gastric peptides in patients with dyspepsia and IBS [111–113]. In particular, considering the Hp -associated dyspepsia, gastrin levels increase during Hp infection and return to normal after eradication of the infection [114].…”

Section: Clinical Significance Of Eggmentioning

confidence: 99%

Electrogastrography in Adults and Children: The Strength, Pitfalls, and Clinical Significance of the Cutaneous Recording of the Gastric Electrical Activity

Riezzo

Russo

Indrio

2013

BioMed Research International

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Cutaneous electrogastrography (EGG) is a non-invasive technique to record gastric myoelectrical activity from the abdominal surface. Although the recent rapid increase in the development of electrocardiography, EGG still suffers from several limitations. Currently, computer analysis of EGG provides few reliable parameters, such as frequency and the percentage of normal and altered slow wave activity (bradygastria and tachygastria). New EGG hardware and software, along with an appropriate arrangement of abdominal electrodes, could detect the coupling of the gastric slow wave from the EGG. At present, EGG does not diagnose a specific disease, but it puts in evidence stomach motor dysfunctions in different pathological conditions as gastroparesis and functional dyspepsia. Despite the current pitfalls of EGG, a multitasking diagnostic protocol could involve the EGG and the 13C-breath testing for the evaluation of the gastric emptying time—along with validated gastrointestinal questionnaires and biochemical evaluations of the main gastrointestinal peptides—to identify dyspeptic subgroups. The present review tries to report the state of the art about the pathophysiological background of the gastric electrical activity, the recording and processing methodology of the EGG with particular attention to multichannel recording, and the possible clinical application of the EGG in adult and children.

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“…Motilin and somatostatin play a role in fasting motor activity, whereas cholecystokinin (CCK), gastrin, neurotensin, pancreatic polypeptide and other peptides affect postprandial activity [1]. Some authors have correlated severe dyspeptic symptoms with elevated levels of gastrin, CCK [2], and somatostatin [3]. Others have reported a reduced pancreatic polypeptide response in dyspeptic patients, suggesting an efferent vagal dysfunction [4].…”

Section: Introductionmentioning

confidence: 99%

Gastric Electrical Activity and Gastrointestinal Hormones in Dyspeptic Patients

et al. 2001

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Aims: To explore the patterns of gastric electrical activity, gastric emptying and gastrointestinal hormones in dyspeptic patients and relate them to Helicobacter pylori status. Methods: Twenty-two patients with functional dyspepsia and 29 healthy volunteers underwent cutaneous electrogastrography and dynamic ultrasound before and after a test meal. All dyspeptic patients underwent endoscopy and biopsy; all subjects were examined for the presence of antibodies to H. pylori, and the plasma levels of gastrin, neurotensin, cholecystokinin, and pancreatic polypeptide were measured. Results: The area under the curve (AUC) of the normal slow wave percentage was lower in dyspeptic patients than controls (Kruskal-Wallis p = 0.016; Dunn’s test: H. pylori-positive patients: 21,235.5 [19,101.0–22,688.8] vs. H. pylori-negative controls: 22,532.0 [20,133.0–23,755.0], p < 0.05). The AUC of the tachygastria percentage was higher in dyspeptic patients than controls (p = 0.0001; H. pylori-positive patients: 2,173.5 [325.8–3,055.3] vs. H. pylori-negative controls: 682.0 [118.5–1,902.4], p < 0.05; H. pylori-negative patients: 1,843.0 [1,107.0–4,277.0] vs. H. pylori-negative controls: 682.0 [118.5–1,902.4], p < 0.05). The AUC of gastrin was higher in H. pylori-positive than H. pylori-negative subjects (p = 0.0002; H. pylori-positive patients: 16,146.5 [11,368.8–33,141.7] vs. H. pylori-negative controls: 11,250.0 [5,674.0–17,448.0], p < 0.05; H. pylori-positive controls: 20,250.0 [12,070.0–64,430.0] vs. H. pylori-negative controls: 11,250.0 [5,674.0–17,448.0], p < 0.05). In the total group of dyspeptic patients and in the H. pylori-positive patients, a negative correlation was found between the AUC of neurotensin and the total score for postprandial fullness (dyspeptic patients r = –0.51, p = 0.01; H. pylori-positive patients r = –0.66, p = 0.02). Conclusions: In dyspeptic patients, alterations in gastric electrical activity were not related to H. pylori infection. Nevertheless, H. pylori infection induces higher gastrin levels in both patients and asymptomatic subjects.

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Gastrin, Cholecystokinin, and Somatostatin in a Laboratory Experiment of Patients With Functional Dyspepsia

Cited by 32 publications

References 25 publications

Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia

Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia

Electrogastrography in Adults and Children: The Strength, Pitfalls, and Clinical Significance of the Cutaneous Recording of the Gastric Electrical Activity

Gastric Electrical Activity and Gastrointestinal Hormones in Dyspeptic Patients

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