Gastrin-related peptides as stimulants of pancreatic and gastric secretion

Gastrin receptors on isolated canine parietal cells.

“…Our present finding that CCK8 stimulates the isolated canine parietal cell with a potency and efficacy equal to that of GI 7 agrees with the observation that CCK is a full agonist of gastric acid secretion in vivo in the cat (46). However, in the dog, CCK weakly stimulates acid secretion (47). Thus, either the isolated canine parietal cell has very limited usefulness as a model for exploring physiologic mechanisms, or there are cellular elements involved in the response of the fundic mucosa to gastrin and CCK in addition to the parietal cell itself.…”

The action of secretin, cholecystokinin‐‐pancreozymin and caerulein on pancreatic secretion in the rat

“…Tracy & Gregory (1964) showed that the C-terminal tetrapeptide which is common to CCK-PZ, caerulein and gastrin possessed all the biological properties of the whole gastrin molecule, including the ability to stimulate fluid and protein secretion from the pancreas of the dog. Stening & Grossman (1969) have since demonstrated in the dog that although the relative potencies of CCK-PZ, caerulein and gastrins I and II varied, they were essentially parallel for the stimulation of protein output and the rate of flow of pancreatic juice. The results obtained in the present study show that in the rat also the actions of CCK-PZ and caerulein in stimulating rate of flow of pancreatic juice were parallel to their actions in stimulating protein output.…”

Secretion of electrolytes by the pancreas of the anaestetized rat.

“…Recently, however, Dockray (1972) Grossman, 1969;Debas & Grossman, 1973); however, unlike the rat, it responds even more vigorously to secretin. Dockray (1972) calculates that the CCK responses of the two species, when corrected for pancreatic weights, are of about the same size.…”