Gastrin-releasing peptide links stressor to cancer progression

Li, Xinqiu; Lv, Yunfu; Yuan, Ang; Li, Zongfang

doi:10.1007/s00432-010-0766-2

Cited by 11 publications

(7 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,11 Therefore, chronic stress may influence cancer cells by the release of GRP, further activating the sympathetic nerve system and the hypothalamic-pituitary-adrenal axis through the release of stress hormones. 38 Another possibility is that GRP is provided to tumors by PNECs. PNECs are resident lung cells and have been suggested to be the cell of origin for some SCLCs.…”

Section: Discussionmentioning

confidence: 99%

“…Tumors often resemble integrated organs, being composed by different cells, which work coordinately. Although both central and sympathetic nerve elements are present in different types of tumors, 38 little is known regarding the roles they play. Sympathetic nerve fibers that reach tumors can release neurotransmitters and neuropeptides locally, 12 activating signaling pathways that can facilitate tumor growth.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

et al. 2017

View full text Add to dashboard Cite

Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor, gastrin-releasing peptide receptor, expressed by many tumors. Although neuropeptides have been previously linked to tumor cell proliferation, more recent studies have uncovered roles for neuropeptides in chemotaxis and metastasis. Understanding the precise roles of such peptides in cancer is crucial to optimizing targeted therapy design. We have previously described that gastrin-releasing peptide acts directly as a chemotactic factor for neutrophils, dependent on PI3K, ERK, and p38. In this study, we investigated roles for gastrin-releasing peptide in lung adenocarcinoma. We asked if gastrin-releasing peptide would act as a proliferative and/or chemotactic stimulus for gastrin-releasing peptide receptor-expressing tumor cells. In A549 cells, a non-small cell lung carcinoma line, the treatment with gastrin-releasing peptide leads to activation of AKT and ERK1/2, and production of reactive oxygen species. Gastrin-releasing peptide induced migration of A549 cells, dependent on gastrin-releasing peptide receptor and PI3K, but not ERK. However, no proliferation was observed in these cells in response to gastrin-releasing peptide, and gastrin-releasing peptide did not promote resistance to treatment with a chemotherapy drug. Our results suggest that, similar to what happens in neutrophils, gastrin-releasing peptide is a migratory, rather than a proliferative, stimulus, for non-small cell lung carcinoma cells, indicating a putative role for gastrin-releasing peptide and gastrin-releasing peptide receptor in metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The interaction of GRP-R with GRP influences a wide range of physiological processes including thermoregulation, gastric and pancreatic secretion, stress responses, and food intake and satiety [3]. Increasing evidence has suggested that GRP and its receptor act as a mitogen, morphogen, and proangiogenic factor in many types of cancer, and an inflammatory mediator in inflammatory cells and vascular cells [4,5].…”

Section: Introductionmentioning

confidence: 99%

Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells

Park

Kim

Bae

et al. 2018

IJMS

View full text Add to dashboard Cite

Gastrin-releasing peptide (GRP), a member of bombesin-like peptides, and its receptor (GRP-R) play an important role in various physiological and pathological conditions. In this work, we investigated the role of GRP-R on adipogenesis in 3T3-L1 adipocytes. The expression of GRP-R was significantly increased during the adipocyte differentiation of 3T3-L1 cells. The inhibition of GRP-R by the antagonist RC-3095 affected adipogenesis in 3T3-L1 cells, which reduced lipid accumulation and regulated the expression of adipogenic genes. Moreover, cyclic AMP response element-binding protein (CREB) directly bound to the GRP-R promoter upon exposure to adipogenic stimuli. The down-regulation of GRP-R by the knockdown of CREB inhibited adipocyte differentiation of 3T3-L1 cells. Together these results suggest that the regulation of GRP-R activity or expression has an influence on adipogenesis through regulating adipogenic related genes.

show abstract

“…The BBN-based peptides, having high binding affinity to GRP receptor, could serve as the specific ligand for tumor diagnosis. Hence, the design and development of the new diagnostic or therapeutic conjugates based on BBN has made headway in recent years (22,23). Prasanphanich et al designed radiolabeled BBN conjugates as effective diagnostic/therapeutic targeting vectors for PC-3 human cancers (24).…”

Section: Introductionmentioning

confidence: 99%

A fast tumor‐targeting near‐infrared fluorescent probe based on bombesin analog for in vivo tumor imaging

Chen

Wan

Zhu

et al. 2014

Contrast Media & Molecular

View full text Add to dashboard Cite

Bombesin (BBN), an analog of gastrin-releasing peptide (GRP), of which the receptors are over-expressed on various tumor cells, is able to bind to GRP receptor specifically. In this study, a near-infrared fluorescent dye (MPA) and polyethylene glycol (PEG) were conjugated to BBN analog to form BBN[7-14]-MPA and BBN[7-14]-SA-PEG-MPA. The successful synthesis of the two probes was proved by the characterization via sodium dodecylsulfate-polyacrylamide gel electrophoresis, infrared and optical spectra. Cellular uptakes studies indicated that BBN-based probes were mediated by gastrin-releasing peptide receptors (GRPR) on tumor cells and the PEG modified probe had higher affinity. The dynamic distribution and clearance investigations showed that the BBN-based probes were eliminated by the liver-kidney pathway. Furthermore, both of the BBN-based probes displayed tumor-targeting ability in GRPR over-expressed tumor-bearing mice. The PEG modified probe exhibited faster and higher tumor targeting capability than BBN[7-14]-MPA. The results implied that BBN[7-14]-SA-PEG-MPA could act as an effective fluorescence probe for tumor imaging.

show abstract

Gastrin-releasing peptide links stressor to cancer progression

Abstract: GRP is a multi-functional peptide, which acts as a stress mediator as well as a growth factor linking stressor to cancer progression. GRP and its high-affinity receptor are useful targets for the diagnosis and treatment of cancers.

Cited by 11 publications

References 95 publications

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells

A fast tumor‐targeting near‐infrared fluorescent probe based on bombesin analog for in vivo tumor imaging

Contact Info

Product

Resources

About