Gastritis and gastric ulceration

Lawson, H H

doi:10.1002/bjs.1800530603

Cited by 32 publications

(9 citation statements)

References 6 publications

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“…The present limited study is recorded as the findings support an earlier investigation when a comparison was made between the reactions of the lesser and greater curvature mucosa following explantation on to the anterior abdominal wall of the dog (Lawson, 1966(Lawson, , 1968. In the present investigation the total duodenal contents were diverted on to the lesser curvature and the subsequent chronic gastric mucosal reaction (CGMR) examined in the different areas of the stomach of the dog.…”

supporting

confidence: 75%

Is the lesser curvature an area especially susceptible to injury by duodenal contents?

Lawson

1976

Journal of British Surgery

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supporting

confidence: 75%

Is the lesser curvature an area especially susceptible to injury by duodenal contents?

Lawson

1976

Journal of British Surgery

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“…It has been shown (Lawson, 1966) that when mucosa of the greater curvature was explanted onto the anterior abdominal wall of the dog, and subsequently replaced into the stomach, ulceration occurred in the centre of the explant, after 7-10 days. This subsequently healed and full regeneration took place.…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of the present investigation is to compare the reaction of lesser-curve mucosa with that of mucosa from the greater curvature, when both areas are submitted to the effect of severe gastritis.The reaction of explanted greater-curve mucosa has been reported previously (Lawson, 1966), and a similar technique has now been used to study the changes that occur when mucosa of the lesser curvature is explanted, It has also been possible to explant tissue from both curvatures at the same time in the same experimental animal, thus ensuring that both areas were subjected to the same external environment, for the same period of time. …”

mentioning

confidence: 97%

The lesser curvature of the stomach

Lawson

1968

Journal of British Surgery

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THE usual position of gastric ulcers on the lesser curvature is very constant, and many theories have been advanced to explain their position at this site. The purpose of the present investigation is to compare the reaction of lesser-curve mucosa with that of mucosa from the greater curvature, when both areas are submitted to the effect of severe gastritis.The reaction of explanted greater-curve mucosa has been reported previously (Lawson, 1966), and a similar technique has now been used to study the changes that occur when mucosa of the lesser curvature is explanted, It has also been possible to explant tissue from both curvatures at the same time in the same experimental animal, thus ensuring that both areas were subjected to the same external environment, for the same period of time. MATERIAL AND METHODSThe successful construction of lesser-curvature explants was difficult, as a long segment of a relatively small vessel had to be isolated and infarction occurred readily. Three preparations of a total of ten were suitable for study. It was necessary to isolate the left gastric vessel, and then to divide all the branches leading from the main vessel to the back of the stomach, working from within the lesser sac. From the anterior aspect, the oesophageal branch was then defined and ligated. The only remaining branches were those derived from the main vessel, along the lesser curve. The left gastric artery was then dissected free throughout its length down to the hepatic artery in order to obtain adequate mobility. A segment of lesser curvature based on the isolated left gastric vessels was then separated from the main stomach, by cutting between two occluding clamps placed parallel along the lesser curvature. The main stomach was repaired in two layers, and after removal of the clamp, haemostasis in the explant obtained 41 by a continuous full-thickness catgut suture. The mobility of the explant and its vascular pedicle was such that it could be exteriorized on either side of the midline. Biopsies of the whole length of the explant, and of the stomach, were obtained at this time. Each explant was left exposed for a period of 60 days, then dissected free from the anterior abdominal wall, and replaced into the host fundus, again using a two-layer catgut technique. In each case comparable areas in the posterior wall of the fundus of the stomach were chosen as the site of reimplantation, and biopsy of the stomach at this site confirmed that the explants lay within the fundic mucous membrane above the pyloric antrum. In addition, each explant was biopsied at the time of reimplantation and care was taken to preserve the vascular pedicle. The animals were killed on a predetermined date after reimplantation.In I of a total of 6 animals it was possible to establish simultaneous explants of both lesser and greater curvatures. They were exteriorized on either side of the midline (see Fig. I). Again after 60 days the explants were reimplanted into the stomach.When the dogs were killed the reimplanted explants could be readil...

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“…An alternative explanation for the localization of an area of CGMR may be that different areas of mucosa react in different ways to a particular injury. It has already been shown that when the mucosa is injured by the sudden and severe stimulus of exteriorization, different areas of the stomach respond in a very similar way (Lawson, 1966(Lawson, , 1968. In the present investigation the CGMR caused by refluxing duodenal contents has been compared in the different areas of the stomach.…”

Section: Discussionmentioning

confidence: 86%