Gastritis cystica profunda: Endoscopic ultrasound findings and review of the literature

Machicado, Jorge D.; Shroff, Jennifer; Quesada, Andres; Jelinek, Katherine; Spinn, Mathew P.; Scott, Larry D.; Thosani, Nirav

doi:10.4103/2303-9027.131041

Cited by 30 publications

(25 citation statements)

References 16 publications

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“…On endoscopic ultrasonography, low echoic lesions are detected in the submucosal layer, which is useful to discriminate from GA-FG-CCP with an SMT-like elevated shape[26]. Histological features that help to exclude the possibility of malignancy include the absence of cytologic atypia, lack of desmoplasia, and the presence of a surrounding lamina propria.…”

Section: Differential Diagnosismentioning

confidence: 99%

Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Miyazawa

Matsuda

Yano

et al. 2016

WJG

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Gastric adenocarcinoma of the fundic gland (chief cell-predominant type, GA-FG-CCP) is a rare variant of well-differentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis.

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Section: Differential Diagnosismentioning

confidence: 99%

Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Miyazawa

Matsuda

Yano

et al. 2016

WJG

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“…The use of gastroscopy for opportunistic screening of gastric cancers is widely accepted, while the use of this procedure for mass screening of gastric cancers remains questionable, even in developed countries such as Japan (Leung et al 2008). Various imaging modalities are used to detect gastric lesions, including endoscopy, barium studies, computed tomography, magnetic resonance imaging and ultrasound (Altonbary et al 2015;Liu and Adler 2014;Liu et al 2014aLiu et al , 2014bMachicado et al 2014;Rana et al 2015;Salah and Faigel, 2014). Among these, the double-contrast barium meal continues to be the most common mass screening tool for gastric cancers in Japan and Korea (Lee et al 2011;Leung et al 2008;Nakajima 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Liu

Guo

Wang

et al. 2017

Ultrasound in Medicine & Biology

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The aim of this study was to assess the role of transabdominal ultrasound with cellulose-based oral contrast agent (TUS-OCCA) in the detection and surveillance of gastric ulcer. The study was approved by the institutional review board at Shengjing Hospital of China Medical University. A total of 124 consecutive patients with benign gastric ulcer diagnosed by gastroscopy and biopsy were enrolled. Serial TUS-OCCA (approximately 1 exam every 2 wk) was performed to monitor the effects of treatment, and additional interventions were planned according to the results. TUS-OCCA detected gastric ulcer in 76% of patients (94 of 124). The detection rates for lesions of ≤5 mm, lesions of 5-10 mm, lesions of 10-15 mm and lesions >15 mm were 32% (10 of 31), 77% (27 of 35), 96% (25 of 26) and 100% (32 of 32), respectively. The detection rates for lesions located in the antrum, angle and body were 70%, 84% and 85%, respectively. Among 30 undetected lesions, which ranged 2-13 mm in size, 11 were at the antrum, 9 at the angle, 3 in the body, 6 at the cardia and 1 at the fundus. During the follow-up period, patients underwent a mean of 3.8 TUS-OCCA examinations (range 2-7), and ulcers were healed after 8 wk (range 2-12 wk) of standard therapy in 76 patients. Eighteen patients who did not show improvement after standard therapy underwent repeat gastroscopy with biopsy. Repeat biopsy was positive for gastric cancer in 4 of these: 2 of the remaining 14 were diagnosed with gastric cancer at gastrectomy, and 12 were diagnosed with chronic benign ulcer. These results indicate that serial TUS-OCCA can be used for close monitoring during routine treatment of gastric ulcers that are detectable by TUS-OCCA and that monitoring by TUS-OCCA can guide additional interventions. A non-invasive follow-up program based on TUS-OCCA can also help to detect gastric cancers that have been misdiagnosed as benign ulcers at the initial endoscopic biopsy.

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“… 4 The findings of a heterogeneously enhancing polypoid lesion with cystic components on EUS should raise the suspicion for GCP. 2 , 4 Previously, gastric resection was the treatment of choice, but more recently, EMR and endoscopic submucosal dissection have become the diagnostic modalities of choice, with only some cases needing further treatment with surgical resection. In the case of our patient, EUS showed a sessile polyp measuring 45 mm with overlying bleeding.…”

Section: Case Reportmentioning

confidence: 98%

Gastritis Cystica Profunda: A Deeper Problem

McCurdy

Parmar

Melo

2016

ACG Case Reports Journal

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Gastritis cystica profunda: Endoscopic ultrasound findings and review of the literature

Cited by 30 publications

References 16 publications

Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Gastritis Cystica Profunda: A Deeper Problem

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