Gastritis cystica profunda in a patient with no history of gastric surgery

Béchade, Dominique; Desrame, Jérôme; Algayres, J. P.

doi:10.1055/s-2006-945070

Cited by 28 publications

(30 citation statements)

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“…1 It occurs not only at the site of gastroenterostomy, but also in the stomach without previous gastric surgery. [2][3][4][5] GCP may present as a subepithelial tumor or a polyp, but rarely as a giant gastric mucosal fold. 6,7 GCP is usually regarded as a benign lesion, 3,4,8 but there are some controversies about its malignant potential.…”

Section: Introductionmentioning

confidence: 99%

Gastritis Cystica Profunda Accompanied by Multiple Early Gastric Cancers

Moon

Kim

Park

et al. 2010

Korean J Gastroenterol

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Gastritis cystica profunda (GCP) is a rare disease which shows multiple cystic gastric glands within the submucosa of the stomach. GCP lesions mainly develop at the site of gastroenterostomy and exhibit benign behavior. However, there have been a number of debates over its malignant potential. Several reports have documented GCP accompanied by gastric carcinomas, but the relationship between the two conditions remains uncertain. Here we report two cases of GCP with dysplasia accompanied by synchronous multiple early gastric cancers without previous gastric surgery. (Korean J Gastroenterol 2010;55:325-330)

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Section: Introductionmentioning

confidence: 99%

Gastritis Cystica Profunda Accompanied by Multiple Early Gastric Cancers

Moon

Kim

Park

et al. 2010

Korean J Gastroenterol

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“…Whether GCP develops secondary to chronic inflammation, foreign body reaction or ischemic injury is unclear, but some interruption of the muscularis mucosa allows migration of epithelial cells into the submucosal layer and subsequent cystic dilation [6]. The majority of reported cases occurred in patients with a history of gastric surgery (65%), however, as in the current case, GCP has been described in non-operated patients as well [3,6,9,10]. Mucosal prolapse and duodenal reflux which may occur following gastric surgery are believed to propagate the cystic changes observed within the submucosa [1,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 65%

“…GCP is a rare gastric lesion characterized by the presence of gastric glands in the submucosa of the stomach with normal overlying mucosa and is often mistaken for other more common gastric pathologies [3][4][5][6][7][8]. An unspecified mucosal insult or injury is widely accepted as the nidus for GCP genesis, however, the pathophysiology is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…However, it was not until 1981 that Franzin and Novelli coined the term "gastritis cystica profunda," and described fifteen cases of GCP that were initially confused with other gastric pathologies, such as mature erosions and gastric adenomas [2]. Since that time, very few additional cases of GCP have been reported, and in these instances GCP was initially thought to represent Ménétrier's disease, [3][4][5] gastric adenocarcinoma, [6,7] inverted hyperplastic polyps, [8] and other pathologies. This report describes a rare case of a GCP in the antrum of a surgery-naïve 39 year-old female which endoscopically and sonographically was consistent with a gastrointestinal stromal tumor (GIST).…”

Section: Introductionmentioning

confidence: 99%

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Gastritis Cystica Profunda: A Rare Gastric Tumor Masquerading as a Malignancy

Laratta¹,

Buhtoiarova²,

Sparber³

et al. 2012

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Introduction: Gastritis cystica profunda (GCP) is a rare tumor which occurs more commonly in patients with prior gastric surgery. The nonspecific symptoms and radiographic appearance of this tumor mimic that of other hyperproliferative conditions making diagnosis difficult without definitive surgical resection. This report provides a comprehensive review of GCP and all GCP cases reported to date. Methods: A comprehensive literature search (1972-2011) was conducted with all reported GCP cases analyzed. Keywords searched included gastritis cystica profunda, submucosal cysts of the stomach, and heterotopic submucosal gastric glands. Results: Thirty-seven GCP cases have been reported since 1972, which includes 29 (78%) men and 8 (21%) women (M:F ratio, 3.6:1). The overall mean age was 60.5 years (range, 39 -81 years) with 55.6 years (range, 39 -79) and 62.2 years (range, 39 -81 years) in women and men, respectively. 65% (N = 24) had prior gastric surgery. 62% (N = 23) of GCP tumors were located in the body; 24% (N = 9) in the fundus; 8% (N = 3) in the antrum; or 6% (N = 2) in the cardia of the stomach. GCP was an incidental finding in 19% of patients. Complete excision was performed most often (73%) followed by endomucosal resection (18%), and polypectomy (4.5%). One patient underwent surveillance (4.5%). Conclusions: GCP is a rare gastric tumor, which is difficult to diagnose preoperatively and masquerades as a malignancy. GCP is more common in men and typically presents with nonspecific symptoms. Although a benign lesion, GCP may represent an intermediate histology in the malignant progression to gastric neoplasia. To date, there have been no reports of local recurrence or distant metastasis following definitive surgical excision, which remains the standard of care.

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“…It mostly involves the gastric fundus and body [1]. GCP is characterized by a diffuse submucosal proliferation of cystic glands that mostly develops in patients who have undergone gastroenterostomy [2]. To our knowledge this is only the second report of MD associated with antral polyposis and GCP [3].…”

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confidence: 88%