Gastritis cystica profunda recurrence after surgical resection: 2-year follow-up

Wang, Lei; Yan, Hua; Huo, Li; Huo, Haizhong; Wang, Bing; Chen, Ying; Liu, Hailin

doi:10.1186/1477-7819-12-133

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…CGD occurs due to hyperplasia and cystic dilatation of submucosal glands extending into the submucosal layer ( 27 ). Although it is accepted as a benign lesion, there is still debate about its malignancy potential ( 28 – 31 ). This relation between CGD and malignancy indicates that a common factor causes both pathologies ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model

Gülçiçek

Özdoğan

Solmaz

et al. 2016

Food & Nutrition Research

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IntroductionObesity has recently become a major health problem, and researchers have been directed to work toward the development of surgical techniques, with new mediators playing an important role in nutrition. Gastric plication (GP) and sleeve gastrectomy (SG) have become popular recently. These are widely used techniques in bariatric surgery.ObjectivesIn this study, we aimed to compare the efficiency of SG and GP techniques on rats.MethodsWistar-Hannover rats (n=18) were divided into three equal groups, namely SG, GP, and control. Blood samples were taken before the operation and on the 30th day after the operation. The weights of all rats were recorded both on first day and the 30th day after the operation. Serum gastrin, ghrelin, and leptin levels were also measured on the same days. For histopathological examination, gastrectomy was performed after the animals were sacrificed.ResultsAverage weight loss was 10% for the SG group and 6.5% for the GP group. One month after the operations, the decrease in the ghrelin and leptin levels of GP and SG groups was significant compared with the levels of the control group. Gastrin levels of the SG group increased significantly compared with those of the control group. Histopathological examination revealed that there was significant decrease in the ghrelin and leptin levels of the GP and SG groups compared with those of the control group. Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.ConclusionAlthough GP is not as effective as SG in terms of weight loss, it provides the same effectiveness in decreasing ghrelin and leptin levels. Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

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Section: Discussionmentioning

confidence: 99%

Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model

Gülçiçek

Özdoğan

Solmaz

et al. 2016

Food & Nutrition Research

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“…The rate of recurrence is not well studied for GPC. To date, two cases of recurrence have been reported after surgical resection (33,39). Meanwhile, a 10-year follow-up of a case of GCP in an unoperated patient revealed low-grade dysplasia, and the sizes of both the GCP and the adenoma overlying had increased during the follow-up period (45).…”

Section: Discussionmentioning

confidence: 99%

Gastritis cystica profunda: a case report and literature review

Du¹,

Zhang²,

Ma³

et al. 2020

Ann Palliat Med

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Gastric cystica profunda (GCP) is a rare disease characterized by multiple cystic lesions in the mucosa and/or submucosal layer. Usually, GCP occurs in stomachs that have previously been operated on.If there is no postoperative pathological results, it is challenging to diagnose GCP based on nonspecific clinical symptoms and imaging findings. This report aimed to provide a comprehensive overview of all cases of GCP reported to date. A comprehensive literature search was conducted for all reported GCP cases between 1972 and 2014. The keywords searched included "gastritis cystica profunda", "submucosal cysts of the stomach", and "heterotopic submucosal gastric glands". One retrospective case from our group was also reported and compared with those from the existing literature. A total of 52 cases were found including 37 (71.2%) men and 15 (28.8%) women (M/F ratio =2.5). The mean age of the patients was 59.9 (range, 39-91) years old. Among the cases, 58.8% (n=30) of lesions were located in the gastric body, 25.5% (n=13) of lesions were located in the fundus, 19.6% (n=9) of lesions were located in the antrum, and 3.9% (n=2) of lesions were located in the cardia, while 1 case was in the prepyloric lesion and 1 case was at the anastomotic site. Of the patients, 52% (n=26) had previously received gastric surgery. The main manifestations of GCP included abdominal pain (n=14, 36.8%) and gastrointestinal bleeding (including hematemesis and melena, n=7, 18.4%). Only 4 of the 52 cases were diagnosed before surgery, and the rest were diagnosed through postoperative histopathologic examination. GCP is difficult to correctly diagnose preoperatively due to its relative rarity and lack of typical clinical symptoms. Histopathological examination should be used for correct diagnosis. Complete surgical removal of the GCP is widely considered as the best treatment option.

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“…Much of the literature available is based on case reports; hence, recurrence and long-term follow-up have not been adequately evaluated. (1)(2)(3)(6)(7)(8)(9)(10)(11) Laratta et al reviewed all published case reports on GCP from 1972 to 2011. (3) They found 37 cases, with a male:female ratio of 3, 6:1, with a mean age of 60.5 years.…”

Section: Discussionmentioning

confidence: 99%

A Case of Gastritis Cystica Profunda (GCP) Mistaken for a Gastrointestinal Stromal Tumour

Naadiyah¹,

Khan²,

Marumo³

2020

Wits Journal of Clinical Medicine

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Gastritis cystica profunda recurrence after surgical resection: 2-year follow-up

Cited by 11 publications

References 16 publications

Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model

Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model

Gastritis cystica profunda: a case report and literature review

A Case of Gastritis Cystica Profunda (GCP) Mistaken for a Gastrointestinal Stromal Tumour

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