Gastro-Oesophageal Cancer Related Pain Syndrome: A Challenge Case to Manage

Elzohry, Alaa Ali M.; Mohammed, Khalid Fawzy; Aly, Asmaa Mohamed

doi:10.33425/2639-846x.1024

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is highly disappointing and surprising at the same time because most types of cancer can be effectively treated through current therapies, especially with all the technological advancements; nevertheless, cancer patients continue to experience an excruciating amount of pain and it remains to be a disease without a cure. Cancer also remains to be one of the most frightening and traumatizing experiences for anyone bearing this diagnosis, despite all the progress and advancements in prevention, early detection, and newer, more effective treatment modalities [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

et al. 2023

View full text Add to dashboard Cite

Cancer is the leading cause of death, acting as a global burden, severely impacting the patients’ quality of life and affecting the world economy despite the expansion of cumulative advances in oncology. The current conventional therapies for cancer which involve long treatment duration and systemic exposure of drugs leads to premature degradation of drugs, a massive amount of pain, side effects, as well as the recurrence of the condition. There is also an urgent demand for personalized and precision-based medicine, especially after the recent pandemic, to avoid future delays in diagnosis or treatments for cancer patients as they are very essential in reducing the global mortality rate. Recently, microneedles which consist of a patch with tiny, micron-sized needles attached to it have been quite a sensation as an emerging technology for transdermal application to diagnose or treat various illnesses. The application of microneedles in cancer therapies is also being extensively studied as they offer a myriad of benefits, especially since microneedle patches offer a better treatment approach through self administration, painless treatment, and being an economically and environmentally friendly approach in comparison with other conventional methods. The painless gains from microneedles significantly improves the survival rate of cancer patients. The emergence of versatile and innovative transdermal drug delivery systems presents a prime breakthrough opportunity for safer and more effective therapies, which could meet the demands of cancer diagnosis and treatment through different application scenarios. This review highlights the types of microneedles, fabrication methods and materials, along with the recent advances and opportunities. In addition, this review also addresses the challenges and limitations of microneedles in cancer therapy with solutions through current studies and future works to facilitate the clinical translation of microneedles in cancer therapies.

show abstract

Section: Introductionmentioning

confidence: 99%