Gastro-oesophageal reflux. Part 2: medical treatment

Talalwah, Narmeen Al; Woodward, Sue

doi:10.12968/bjon.2013.22.5.277

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…The dose recommended by WHO for ranitidine is 150 mg tablet containing ranitidine base, given as the hydrochloride salt [4,11]. Twice-daily treatment with ranitidine 150 mg is a valuable therapy for GERD in a typical family practice setting and reduces the frequency and severity of symptoms within the first 24 to 48 hours of treatment [12]. Another study conducted in Oman showed that different brands of ranitidine Modern Chemistry & Applications available in market that pharmaceutical equivalent with a slight difference in manufacturing process [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Four Different Brands of Ranitidine Available in Karachi

Huma Dilshad

2014

Mod Chem Appl

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Ranitidine is used in peptic ulcer therapy and available as several brands in the market which makes it difficult to select the safe, effective and economic one. The aim of this study is to establish similarity among the different brands of ranitidine HCl tablets available in local market of Karachi, Pakistan. Four different brands of (150 mg) were selected for the study. Six quality control parameters: weight variation test, hardness test, thickness, friability, disintegration test and dissolution test were carried out specified by USP. Result revealed that all brands comply within limits for hardness, weight variation, thickness, friability, disintegration and dissolution. Disintegration time for all brands was within 15 minutes complying with the USP commendation. All brands showed Q-value more than 80% within 45 minutes. The present findings suggest that almost all the brands of ranitidine HCl that are available in Karachi meet the USP specification for quality control analysis and are interchangeable.

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Section: Introductionmentioning

confidence: 99%