Gastro‐oesophageal reflux symptoms and health‐related quality of life in the adult general population – the Kalixanda study

Ronkainen, Jukka; Aro, Pertti; Storskrubb, Tom; Lind, Tore; Bolling–Sternevald, Elisabeth; Junghard, Ola; Talley, Nicholas J.; Agréus, Lars

doi:10.1111/j.1365-2036.2006.02952.x

Cited by 158 publications

(132 citation statements)

References 39 publications

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“…Gastroesophageal reflux disease (GERD) is a highly prevalent disease in Western populations, (1,2) associated with a decreased health-related quality of life (3,4) and an increased risk of esophageal adenocarcinoma. (5,6) The Montreal definition and classification of GERD states that: "GERD is a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications" and the definition recognizes that heartburn and acid regurgitation are characteristic symptoms of GERD.…”

Section: Introductionmentioning

confidence: 99%

Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study

Ness-Jensen

Lindam

Lagergren³

et al. 2013

American Journal of Gastroenterology

132

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Word count 3000Weight loss and gastroesophageal reflux 3 ABSTRACT Objective High body mass index (BMI) is an established risk factor of gastroesophageal reflux symptoms (GERS). The aim of this study was to clarify if weight loss reduces GERS. DesignThe study was part of the Nord-Trøndelag health study (the HUNT study), a prospective population-based cohort study conducted in Nord-Trøndelag County, Norway. All residents of the county from 20 years of age were invited. In 1995-7 (HUNT 2) and 2006-9 (HUNT 3), 58,869 and 44,997 persons, respectively, responded to a questionnaire on heartburn and acid regurgitation. Among these, 29,610 persons (61% response rate) participated at both times and were included in the present study. The association between weight loss and reduction of GERS was calculated using logistic regression. The analyses were stratified by antireflux medication and the results adjusted for sex, age, cigarette smoking, alcohol consumption, education, and physical exercise.Results Weight loss was dose-dependently associated with a reduction of GERS and an increased treatment success with antireflux medication. Among persons with >3.5 units decrease in BMI, the adjusted OR of loss of any (minor or severe) GERS was 1.98 (95% CI 1.45 to 2.72) when using no or less than weekly antireflux medication, and 3.95 (95% CI 2.03 to 7.65) when using at least weekly antireflux medication. The corresponding ORs of loss of severe GERS was 0.90 (95% CI 0.32 to 2.55) and 3.11 (95% CI 1.13 to 8.58). ConclusionWeight loss was dose-dependently associated with both a reduction of GERS and an increased treatment success with antireflux medication in the general population.

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Section: Introductionmentioning

confidence: 99%

Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study

Ness-Jensen

Lindam

Lagergren³

et al. 2013

American Journal of Gastroenterology

132

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“…Symptoms of reflux disease can be present in up to 40 % of the community and lifelong drug treatment may be required in 15-50 % to relieve these symptoms when surgery is not undertaken [1,2]. The laparoscopic use of the fundoplication surgery, originally defined by Nissen, for the first time in 1991 has made fundoplication a favorable option for the definite treatment or reflux disease, and it has become the standard surgical treatment for the disorder with a well-documented high rate of success in increasing both the general and disease-related quality of life together with proven reliability [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Esophageal Calibration with Soft Orogasrtric Tube During Laparoscopic Nissen Fundoplication may Reduce Postoperative Transient Dysphagia

Bülbüller

Öner

2013

Indian J Surg

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Gastroesophageal reflux is the most common benign disorder of the esophagus and laparoscopic Nissen fundoplication has become the standard surgical treatment for its treatment. In our area, where the use of bougie calibration is debatable, postoperative dysphagia is encountered often after this surgery although it is usually not permanent. The aim of this study was to investigate the effect of using a soft silicone tube 39 F in diameter for esophageal calibration during laparoscopic Nissen fundoplication on the incidence of postoperative dysphagia. We divided cases scheduled to undergo laparoscopic Nissen fundoplication between January 2009 and November 2010 into two groups, each consisting 25 patients. Esophageal calibration with a 39 F silicone orogastric tube was used for the first group while there was no operative calibration in the second group. The surgical duration was recorded; the presence and severity of the postoperative dysphagia was calculated by using a dysphagia severity scoring system during the 1-year postoperative follow-up. The dysphagia severity scores were significantly lower in group 1 than group 2 on the postoperative second day and at the end of the first week and first month. We did not find a significant difference at the end of the 6-month and first year. There was also no significant difference regarding surgery duration. The use of a soft orogastric tube 39 F in diameter for esophagus calibration during laparoscopic Nissen fundoplication has significantly decreased the incidence of postoperative transient dysphagia without affecting the duration of surgery. Although dysphagia gradually resolves in the majority of patients, a safe and easy calibration method for its prevention is worth developing, and we believe that the use of our method in larger series could be beneficial.

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“…Various lifestyle factors are reported to be associated with GERD [15], and reflux symptoms negatively affect health-related quality of life, work productivity, and health resource utilization [16][17][18][19]. The severity of GERD is directly correlated with the degree and duration of esophageal acid exposure and is highly pH dependent [20][21][22] Moreover, reflux oesophagitis is a risk factor for esophageal stricture in 4-20% of patients [20], Barrett's esophagus in up to 15% of patients [21][22][23] and esophageal adenocarcinoma [24].…”

Section: Discussionmentioning

confidence: 99%

Randomized, Comparative Study of Standard Dose of Rabeprazole versus Omeprazole in Gerd/Heartburn Symptom Relief

A¹,

A.O²,

Solomon³

et al. 2016

ijSciences

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Gastro‐oesophageal reflux symptoms and health‐related quality of life in the adult general population – the Kalixanda study

Abstract: SUMMARY BackgroundThe impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized.

Cited by 158 publications

References 39 publications

Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study

Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study

Esophageal Calibration with Soft Orogasrtric Tube During Laparoscopic Nissen Fundoplication may Reduce Postoperative Transient Dysphagia

Randomized, Comparative Study of Standard Dose of Rabeprazole versus Omeprazole in Gerd/Heartburn Symptom Relief

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