Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

Kadasah, Saeed; Eid, Ahmad Saleh Al; Alawad, Salem Saleh; Shahrani, Abdullah S. Al; Alruwaihi, Ahmed Salem; Elfaki, Ibrahim; Arshaduddin, Mohammed

doi:10.1016/j.toxrep.2021.05.004

Cited by 10 publications

(8 citation statements)

References 41 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the biochemical evaluations, in the present study, the macroscopic examinations indicated that pretreatment with topiramate reduced ulcer area and decreased the indomethacin-induced ulcer severity and these ameliorative effects were also observed in histopathologic examinations. These results are in line with the recent study of Kadasah et al 57 who reported a similar effect for topiramate in a rat model of experimentally ethanolinduced gastric mucosal damage. They reported that pretreatment with topiramate ameliorated ethanol-induced gastric damage in rats by inhibiting neutrophil infiltration, inflammation, and apoptosis.…”

Section: Discussionsupporting

confidence: 93%

Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses

Jafari

Andishfar

Esmaeilzadeh

et al. 2022

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Topiramate is an anticonvulsant drug effective against a wide range of seizures and epilepsies. The present study was conducted to investigate the possible protective effect of topiramate on indomethacin‐induced gastric mucosal damage in rats. The animals were randomly distributed into four experimental groups with 10 animals in each group. Group 1 was the control group received vehicle only (DMSO at 1:4 (w/v)), group 2 was the model group received indomethacin (50 mg/kg; i.p.), and groups 3 and 4 received topiramate (100 mg/kg; i.p.) and ranitidine (100 mg/kg; i.p.), respectively, 1 h before indomethacin (50 mg/kg; i.p.). The efficacy of topiramate was compared with ranitidine. Animals were euthanized 4 h after indomethacin administration, and gastric tissues were collected for macroscopical, histopathological, and biochemical analyses. The mucosal lesions in the gastric corpus were evaluated by pathological examinations. The results revealed that the administration of indomethacin caused evident gastric mucosal damage with morphological and histological manifestation, whereas topiramate pretreatment extensively ameliorated the gastric injuries. Topiramate pretreatment also reduced the contents of tissue malonaldehyde, enhanced ferric reducing antioxidant power value and glutathione levels, and increased the activity of superoxide dismutase, catalase, and glutathione peroxidase in gastric mucosa compared to the model group. Our results indicate that topiramate might possess a protective role against indomethacin‐induced gastric ulcers by inhibition of oxidative stress in gastric tissue.

show abstract

Section: Discussionsupporting

confidence: 93%

Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses

Jafari

Andishfar

Esmaeilzadeh

et al. 2022

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…Moreover, ethanol can impede the stomach's capacity to shield itself from injuries by minimizing the production of protective mucus and intensifying the permeability of its lining. These impacts are attributed to ethanol‐induced modifications in the levels of several substances, such as cytokines, prostaglandins, and ROS (Kadasah et al, 2021; Park et al, 2020).…”

Section: Effect Of Turmeric and Curcumin On Ethanol Toxicitymentioning

confidence: 99%

The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

View full text Add to dashboard Cite

Ethanol toxicity is a major public health problem that can cause damage to various organs in the body by several mechanisms inducing oxidative stress, inflammation, and apoptosis. Recently, there has been a growing interest in the potential of herbal medicines as therapeutic agents for the prevention and treatment of various disorders. Turmeric (Curcuma longa) extracts and its main components including curcumin have antioxidant, anti‐inflammatory, and anti‐apoptotic properties. This review aims to evaluate the literature on the ameliorative effects of turmeric extracts and their main components on ethanol toxicity. The relevant studies were identified through searches of Google Scholar, PubMed, and Scopus without any time limitation. The underlying mechanisms of turmeric and curcumin were also discussed. The findings suggest that turmeric and curcumin ameliorate ethanol‐induced organ damage by suppressing oxidative stress, inflammation, apoptosis, MAPK activation, TGF‐β/Smad signaling pathway, hyperlipidemia, regulating hepatic enzymes, expression of SREBP‐1c and PPAR‐α. However, the limited clinical evidence suggests that further research is needed to determine the efficacy and safety of turmeric and curcumin in human subjects. In conclusion, the available evidence supports the potential use of turmeric and curcumin as alternative treatments for ethanol toxicity, but further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.

show abstract

“…Reactive Oxygen Species (ROS) and other inflammatory mediators are overproduced at the site of stomach injury by white blood cells such as neutrophils, which also cause oxidative damage and cell damage 8,9 . Superoxide Dismutase (SOD) and Catalase (CAT), two antioxidant enzymes, as well as the non-enzymatic antioxidant Glutathione (GSH), are less active when Reactive Oxygen Species (ROS) are present 10 . These are some of the factors that contribute to the development of acute gastric ulcers brought on by ethanol and cause cell membrane damage.…”

Section: Introductionmentioning

confidence: 99%

GC-MS and Antioxidative Effects of Poly Herbal Formulation of Persea americana Seed Against Ethanol-Induced Gastric Ulcer in Rats

Umaru,

Ejeh,

Umaru

et al. 2023

Asian J. Biol. Sci

View full text Add to dashboard Cite

Background and Objective: Plant-derived natural products have considerable significant attention due to their various pharmacological properties and functions. Avocado (Persea americana Mill.), is a fruit that is native to Central America. GC-MS analyses of avocado samples showed α-tocopherol, squalene, cycloartenol acetate, β-sitosterol, campesterol and stigmasterol. This study aims to check the gastroprotective and antioxidant effect of avocado seed extract on gastric ulcer. Materials and Methods: A total of 60 experimental rats were used and divided into a group of six in two experimental designs and administered treatments with the crude extract of virgin avocado. Results: Results were expressed as Mean±Standard Error of the Mean (SEM). Statistical significance was determined using a One-way Analysis of Variance (ANOVA) followed by Tukey's post hoc Test. Values of p<0.05 were considered to be significant. The result of the GC-MS profile of the ethanol crude extract of avocado seed extract was found to compose of 30 chemical constituents which can be used to manage different kinds of ailments. Conclusion: Avocado seed extract has potential antioxidant activity in vitro and in vivo. Oral administration of Avocado seed extract once daily for 7 days alleviates gastric ulcers induced by ethanol, but more significant was observed with the formulation.

show abstract

Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

Abstract: Graphical abstract

Cited by 10 publications

References 41 publications

Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses

Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses

The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity

GC-MS and Antioxidative Effects of Poly Herbal Formulation of Persea americana Seed Against Ethanol-Induced Gastric Ulcer in Rats

Contact Info

Product

Resources

About