Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

Zaghlool, Sameh S.; Abo-Seif, Ali A.; Rabeh, Mohamed A.; Abdelmohsen, Usama Ramadan; Messiha, Basim AS

doi:10.37247/pab.1.2022.7

Advances in Energy Research 2022

DOI: 10.37247/pab.1.2022.7

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Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

Sameh S. Zaghlool¹,

Ali A. Abo-Seif²,

Mohamed A. Rabeh³

et al.

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“…In addition, some of these treatments may cause side effects like hypersensitivity, arrhythmia, weakness, and hematopoietic disorders. 22 However, treating this problem with alternatives that could have minimal side effects is urgently needed. Several clinical studies 22,23 have been…”

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confidence: 99%

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The Counter-Effect of Glycyrrhiza glabra Against Gastrointestinal Tract Toxicity of Indomethacin on Rats

2023

TJNPR

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NSAIDs cause gastrointestinal toxicity by inhibiting cyclooxygenase, interfering with prostaglandin production and their action. When prostaglandin synthesis is suppressed, gastric mucosal blood flow is reduced, microcirculation is disrupted, mucus secretion decreases, lipid peroxidation occurs, and neutrophil activation contributes to gastrointestinal mucosal disorders. 12,13 Gastritis is the gastric mucosa inflammation associated with gastric mucosal injury; this inflammation can be classified into acute and chronic gastritis according to the duration of mucosal inflammation. Helicobacter pylori (H. pylori) infection is among the predominant causes of chronic gastritis that could lead to gastric atrophy and intestinal metaplasia and could be diffuse (pangastritis or multifocal gastritis), antrum-predominant, or corpus-predominant. [14][15][16] Some studies have found that H. pylori infection may pass out in young children. However, this was not reported in adult patients. [17][18][19] Irritants such as bacterial endotoxins, alcohol, coffee, and aspirin consumption were reported as causes of acute gastritis characterized by transient nonspecific dyspeptic symptoms. 20 Furthermore, it is self-limiting, and the symptoms of acute gastritis include heartburn, temporal gastric distress, vomiting, massive proximal and distal stomach mucosal inflammation (pangastritis), and, in severe cases, may develop bleeding and hematemesis. 21 Acute gastritis often correlates with hypochlorhydria, which may persist for months. The treatment options for acute gastritis include antacids, antibiotics, sucralfate, histamine-2-receptor antagonists, proton pump inhibitors, and many other agents. In addition, some of these treatments may cause side effects like hypersensitivity, arrhythmia, weakness, and hematopoietic disorders. 22 However, treating this problem with alternatives that could have minimal side effects is urgently needed. Several clinical studies 22,23 have been

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mentioning

confidence: 99%

“…22 However, treating this problem with alternatives that could have minimal side effects is urgently needed. Several clinical studies 22,23 have been…”

mentioning

confidence: 99%

The Counter-Effect of Glycyrrhiza glabra Against Gastrointestinal Tract Toxicity of Indomethacin on Rats

2023

TJNPR

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show abstract

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Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

Cited by 1 publication

References 0 publications

The Counter-Effect of Glycyrrhiza glabra Against Gastrointestinal Tract Toxicity of Indomethacin on Rats

The Counter-Effect of Glycyrrhiza glabra Against Gastrointestinal Tract Toxicity of Indomethacin on Rats

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