Gastro Protective and Antioxidant Activity of Solanum nigrum Linn. against Aspirin and Cold Restraint Stress induced Ulcerated Rats

Saravanan, S.; Dhasaratha, P.; Indira, V.; Venkatrama, R.

doi:10.3923/rji.2011.1.11

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…Histopathological studies were performed which showed that there was a significant decrease in gastric ulcerative lesions and perforations in animals pretreated with methanolic leaf extract of S. nigrum. Hence, gastroprotective activity of S. nigrum was due to the presence of active constituents including flavonoids, alkaloids, tannins and terpenoids which showed potent antioxidant activity (Saravanan et al, 2011).…”

Section: Solanum Nigrummentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.</p><p> </p>

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Section: Solanum Nigrummentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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“…So, it can be advocated that the plant extract has potentially reduced the ulcer forming capacity of ethanol in rats [13]. There is evidence of increase int eh free radicle generation in gastric mucosa with the administration of ethanol that causes injury to the mucosal layers in the stomach [14]. From the mechanism of ethanol generating reactive species, the extract was competent enough to ight and scavenge the free radicles that are caused by the ethanol (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-ulcer activity of methanol extract of Tectona grandis Linn

Sm¹,

Hemalatha²

2020

irjpas

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PUD is the most common disease that affects a majority of the population in the world and young people being the most affected out of all the ulcer patients. This disease involves a large number of causes like NSAID, malnutrition and deficiency, unhealthy lifestyles like chronic smoking and stress. In recent years, a rapid progressive understanding had been made concerning the mechanism of ulcers and its treatment protocols. Given the side effects of the available synthetic drugs, it calls for an investigation of newer medications which are of herbal origins. As per the literature, survey says Tectona grandis ethanol extract has been proved to show the anti-ulcer activity and considering the solubility and extractive capabilities of methanol over ethanol; the current research was performed to determine the anti-ulcer potency of methanol extract of Tectona roots. The results showed that Tectona methanol extract is way more efficient in treating ulcers in comparison to the standard drug omeprazole.

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“…Our results on antiulcerogenic capacities of the three genotypes of SLN compare favorably with those of earlier investigators. In the study by Saravanan et al (2011) in which antiulcerogenic effects were analyzed for methanolic extracts of SLN grown in India using asprin and cold restraint stress as ulcer inducers, respective ulcer inhibition rates were 77.85 % and 66.67 %. The study by Jainu & Devi (2004) assessed methanolic extracts of berries of an Indian SLN for gastro protection against aspirin-induced ulcerations in rats and reported ulcer inhibition scores of 49.30, 70.12 and 72.70 % for extract doses of 250, 500 and 1000 mg/kg respectively.…”

Section: Gross Anatomical Findingsmentioning

confidence: 99%

Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study

et al. 2020

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Solanum nigrum (SLN), commonly known as African nightshade, is used as a vegetable as well as in the management and treatment of various ailments including gastric ulcers. We analyzed, both grossly and microscopically using H&E, Masson's trichrome and PSA staining methods, the protective effects of aqueous leaf extracts of three Kenyan SLN genotypes namely S. scabrum (SSB), S. sarrachoides (SSR) and S. villosum (SVL) on ethanol-induced gastric lesions in rats. There was evidence of gastro-protection by all the three genotypes with the SSB showing the highest ulcer inhibition score (76.37 %) followed by SSR (72.51 %) and SVL (63.30 %). SLN-pretreated rats showed less areas of gastric mucosal surface erosion. Additionally in the pretreated animals, the depth of the ulcers were markedly reduced, reaching only the gastric pit region except in those treated with SVL where the ulcers penetrated slightly more deeply to affect the gastric glands. Compared with controls, the mean microscopic ulcer index decreased 5.07, 3.55 and 2.37-fold in rats pretreated with SSB, SSR and SVL extracts respectively. Results of this work show extracts of the three SLN genotypes to have antiulcerogenic potential but at varied strengths, thus confirming earlier reports that phytoconstituents and hence the efficacy of a medicinal plant may be influenced by genetic factors.

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Gastro Protective and Antioxidant Activity of Solanum nigrum Linn. against Aspirin and Cold Restraint Stress induced Ulcerated Rats

Cited by 9 publications

References 10 publications

Medicinal plants with gastroprotective potential

Medicinal plants with gastroprotective potential

Anti-ulcer activity of methanol extract of Tectona grandis Linn

Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study

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