Gastro Protective and Antioxidant Effect of Euphorbia Prostrata Against Indomethacin Induced Gastric Ulcers in Healthy Adult Male Albino Rabbits

Abstract

Euphorbia prostrate belongs to family Euphorbiaceae locally known as Doodhi is small annual herb. Current study was conducted to evaluate the gastro protective and antioxidant effectiveness of the aerial parts of E. prostrata in indomethacin induced ulcer in adult male albino rabbits. A total 36 mice were taken and divided into 6 equal groups. At day 0 and 14 of experiment the blood sample was collected from each animal and serum was separated from blood which was used for the determination of Total oxidant status (TOS), Total antioxidant capacity (TAC), catalase (CAT) and Malondialdehyde (MDA). At the end of the experiment, all of the rabbits were slaughtered. The gastric contents were collected to total acid output, gastric pH and gastric volume. To confirm the data results was subjected to one way analysis of variance (ANOVA). Results when compared with the extensive mucosal damage in the indomethacin trated group, gross evaluation revealed a marked protection of the gastric mucosa in the experimental groups, with significantly reduction in gastric pH, gastric volume and acid output. In these groups, CAT and TAC levels were significantly increased (P < 0.05) and while MDA and TOS significantly reduced (P < 0.05) which indicate reduction in gastric damage. In conclusion to these results E. prostrata has potent antioxidant properties at dose rate of 240 mg/kg and it is also very effective for the treatment of gastric ulcer at the same dose.

Intimate partner physical violence and associated factors in reproductive age married women in Aksum Town, Tigray, Ethiopia 2018, and community based study

“…A woman who had husbands in the age group ≤ 30 years old was 5 times more likely to report intimate partner physical violence than those who had husbands ≥ 41 years old. This result is in contrast with study finding in Hawzen, Ethiopia [25], in our finding as age of husband increasing experience of intimate partner physical violence decreases irrespective of women’s age, but in the study in Hawzen as women’s age increases the experience of intimate partner physical violence increases irrespective of husbands age, it was also in contrast with the report in WHO [14] and Iran [26].…”

“…Our Study finding also less than from the study conducted in Debre Tabor town in 2015, which showed, 56.1% lifetime and 27.9% in the last 12 months [23]. Additionally, another Study conducted in Shimelba refugee camp was 25.5% [12], and Southwest Ethiopia, 64.7% [24], Hawzen, 38.6% which is higher than our study finding [25].…”

Gastro-protective potential of Artemisia parvifloraon aspirin induced gastric ulcers in albino rabbits

“…The mean value of A. parviflora at dose rate of 750 mg/kg was not significantly different from omeprazole. The results of our study conicide with other studies (Aslam et al, 2013;Begum et al, 2014). pH of gastric secretions was measured in the current study.…”