Gastro retention using polymer cocoons

Arnold, Julien; Hunkeler, David

doi:10.3109/21691401.2014.940084

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…The GRT of expandable delivery systems may be enhanced [73]. In order for the system to function well, three main designs must be addressed: restricted space for simple oral intake, increased shape in the belly to restrict passing it via the valve, and system quantity reduction upon total dose forms to assist outflow [27,28,74]. The ability of this mechanism to restrict the valve makes it helpful.…”

Section: Expandable Systemsmentioning

confidence: 99%

Review on Several Approaches Involving Gastro- Retentive Drug Delivery System

2023

IJBPAS

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Any drug delivery technique must deliver a therapeutic dose of medicine to the desired location in the body while also maintaining an effective plasma drug concentration for a certain time period. Incomplete drug release results in a shorter duration of action of the dose form and a decreased bioavailability of the medication. A gastro retention medication delivery device is employed to circumvent this issue. The point of this study is to look at the various medication delivery techniques for gastro-retention that have been utilized to increase the therapeutic effect of pharmaceuticals with a short therapeutic window, are unsteady at basic pH, are soluble in acidic medium, and are active locally in the stomach.The anatomy of the stomach, the factors affecting GRDDS, and the various GRDDS techniques currently used in gastric retention drug delivery systems, such as hydrodynamically balanced systems, super porous hydrogel systems, magnetic systems, muco-adhesive systems, high-density, low-density systems and micro balloon systems are discussed in detail, along with their applications and advantages. Additionally, it considers prospective approaches for increasing stomach retention duration in fasting and fed states. In summary, this research sheds light on existing and future perspectives on gastric retention medication delivery systems.

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Section: Expandable Systemsmentioning

confidence: 99%

Review on Several Approaches Involving Gastro- Retentive Drug Delivery System

2023

IJBPAS

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“…By a pushing activity, the pylorus goes about as a siphon for gastric purging; and assumes a signi icant part in gastric home time. The motility example of the stomach is typically called the moving engine complex (MMC); it is diverse for the fasting and taken care of state (Arnold and Hunkeler, 2015). It comprises of different cycles, the length of each cycle is 90-120 min and it contains four stages, as referenced in (Figure 1).…”

Section: Stomach Physiologymentioning

confidence: 99%

Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems

Saravanakumar²,

Bannoth

2021

ijrps

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Gastro-retentive drug delivery systems (GRDDS) attributes to gastric maintenance time combined with the medication discharge for expanded time has essentially improved patient consistency. Medications for which the chief fundamental site of ingestion is the stomach or the proximal piece of the small digestive tract or have the assimilation issue in the distal piece of the digestive system are reasonable for GRDDS. Orally sustaining or controlling the drug release combined with gastric retention property can avoid recurrent dosing in the case of drugs with short half-lives. GRDDS is also effective in locally treating gastric and duodenal ulcers, including oesophagitis and Helicobacter pylori infections. In this current survey, the physiology of the stomach alongside its motility design, typically called migrating motor complex (MMC), was discussed. Various approaches to GRDDS with a focus on floating drug delivery systems (FDDS) were reviewed. The vacillations in plasma drug focus are limited and portion subordinate unfriendly impacts can be forestalled by FDDS, particularly for the medications with a restricted restorative list. Slow arrival of the medication into the body by means of FDDS limits the counter movement prompting higher medication proficiency. Further, the Advantages, limitations, suitable drug candidates, factors affecting and Future challenges of FDDS were discussed.

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“…Swelling and expandable systems (or "plug type systems" due to their pyloric sphincter blocking attribute) have achieved significant success both in vitro and in vivo in order to retain the dosage form in the stomach [11]. Once the polymer meets the gastric fluid, it absorbs water and swells [12]. The selection of a polymer with the appropriate molecular weight and swelling properties is crucial to enable the dosage form to exhibit sustained-release behavior.…”

Section: Academic Journal Of Polymer Science Cmentioning

confidence: 99%

Polymeric Materials for the Development of Dual↓Working Gastroretentive Drug Delivery Systems. A Breakthrough Approach

Paz¹

2021

AJOP

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Gastro retention using polymer cocoons

Cited by 8 publications

References 28 publications

Review on Several Approaches Involving Gastro- Retentive Drug Delivery System

Review on Several Approaches Involving Gastro- Retentive Drug Delivery System

Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems

Polymeric Materials for the Development of Dual↓Working Gastroretentive Drug Delivery Systems. A Breakthrough Approach

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