Gastrodia elata and parishin ameliorate aging induced ‘leaky gut’ in mice: Correlation with gut microbiota

Gong, Caixia; Ma, Cheng; Irge, Dejene Disasa; Li, Shumin; Chen, Si-Min; Zhou, Shaojun; Zhao, Xiang‐Yu; Li, Hanyu; Li, Jinyou; Yang, Yunmei; Xiang, Lan; Zhang, Qin

doi:10.1016/j.bj.2022.07.001

Cited by 11 publications

(3 citation statements)

References 36 publications

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“…Parishins have been reported to possess unique bioactivity for the treatment of brain disorders such as anti-epileptic, anti-convulsive, sedative, and neuroprotective effects. A recent study reported that parishins exhibited the prevention of gut aging and the improvement of “leaky gut” in aged mice ( Gong et al., 2023 ). Another study has shown that parishin J in G. elata could have protective effects on hypoxia/reoxygenation injury in H9c2 cardiomyocytes ( Wang et al., 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume

Zeng,

Li,

Chen

et al. 2023

Front. Plant Sci.

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Gastrodia elata Blume (Tianma in Chinese), a myco-heterotrophic orchid, is widely distributed in China. Tubers derived from this orchid are traditionally used as both medicinal and edible materials. At present, five primary varieties of G. elata are recorded in the “Flora of China.” Among them, the three main varieties currently in artificial cultivation are G. elata f. elata (GR, red stem), G. elata f. glauca (GB, black stem), and G. elata f. viridis (GG, green stem). In our study, the metabolic profiles and chemical composition of these three varieties were determined via UPLC-MS/MS and HPLC-UV. In total, 11,132 metabolites were detected, from which multiple phytometabolites were identified as aromatic compounds, heteroatomic compounds, furans, carbohydrates, organic acids, and their derivatives. A number of differentially expressed metabolites (DEMs) were annotated as bioactive ingredients. Overall, parishins, vanilloloside, and gastrodin A/B in the GB group were markedly higher, whereas gastrodin, gastrol, and syringic acid were more enriched in the GG or GR groups. Moreover, HPLC fingerprint analysis also found six metabolites used as markers for the identification of Gastrodiae Rhizoma in the Chinese Pharmacopoeia, which were also typical DEMs in metabolomics. Of these, gastrodin, 4-hydroxybenzyl alcohol, citric acid, and adenosine were quantitatively detected, showing a similar result with the metabolomic data. In summary, our findings provide novel insights into the phytochemical ingredients of different G. elata varieties, highlighting diverse biological activities and healthcare value.

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Section: Resultsmentioning

confidence: 99%

Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume

Zeng,

Li,

Chen

et al. 2023

Front. Plant Sci.

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“…A bioactivity test showed that a polysaccharide from Gastrodia elata, named GEP-1, could modulate gut microbiota by promoting the growth of A. muciniphila (A. muciniphila) and Lacticaseibacillus paracasei (L.paracasei) strains ( Huo et al, 2021 ). In addition, another active ingredient from G. elata, parishin, could prevent the loss of tight junction proteins, modulate the composition of gut microbiota to a healthier state in aged mice ( Gong et al, 2023 ). It could alter microbial diversity and decrease the aberrant abundance of pathogenic bacteria, such as Turicibacter and Erysipelatoclostridium ( Zhao et al, 2022 ).…”

Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

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“…G elata Bl. also has modern pharmacological effects, such as antidepressant 2 , 3 , anticonvulsant 4 , 5 , anti–aging 6 , 7 , and neuroprotective effects 8 , 9 , with a thousand years of medicinal use. In 2019, the Chinese government announced the categorization of G elata Bl.…”

Section: Introductionmentioning

confidence: 99%

Discovery of seed germinating fungi (Mycetinis scorodonius) from Gastrodia elata Bl. f. glauca S. chow in Changbai Mountain and examination of their germination ability

Yang,

Gao,

et al. 2024

Sci Rep

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Multi-generational asexual reproduction of Gastrodia elata Bl. will cause seedling species degeneration. Sexual reproduction of Gastrodia elata Bl. seed is an effective method to solve the problem of degeneration. The development of Gastrodia elata Bl. seeds cannot be separated from the germination fungus. However, there are few strains of germination fungus in production, and there is also the problem of species degradation in application for many years. It is very important for the sexual reproduction of Gastrodia elata Bl. to isolate more new strains of excellent germination fungus from the origin. This study used the Gastrodia elata Bl. f. glauca S. chow seeds germination vegetative propagation corms capture method to isolate its symbiotic germination fungus, and comprehensively identified the species of germination fungus by colony morphology, ITS, sporocarps regeneration and germination function, and compared the growth characteristics and germination ability with other germination fungus (Mycena purpureofusca, Mycena dendrobii and Mycena osmundicola). The germination fungus was isolated from the vegetative propagation corms of Gastrodia elata Bl. f. glauca S. chow seeds and named GYGL-1. After comprehensive identification, GYGL-1 was Mycetinis scorodonius. Compared with other germination fungus, GYGL-1 has fast germination speed, vigorous growth, and high germination ability for Gastrodia elata Bl. f. glauca S. chow seeds. Innovated the isolation method of Gastrodia elata Bl. seeds germination fungus, obtained the regenerated sporocarps of the germination fungus, and discovered that Mycetinis scorodonius has a new function of germinating Gastrodia elata Bl. f. glauca S. chow seeds, enriching the resource library of Gastrodia elata Bl. germination fungus.

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Gastrodia elata and parishin ameliorate aging induced ‘leaky gut’ in mice: Correlation with gut microbiota

Cited by 11 publications

References 36 publications

Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume

Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Discovery of seed germinating fungi (Mycetinis scorodonius) from Gastrodia elata Bl. f. glauca S. chow in Changbai Mountain and examination of their germination ability

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