Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against &amp;#946;-amyloid: The involvement of GRP78 and CHOP

Lee, Geum-Hwa; Kim, Hyung‐Ryong; Sang-Yong, Han; Bhandary, Bidur; Kim, Do‐Sung; Kim, Min-Gul; So, Byung‐Ok; Kim, Sun‐Young; Jo, Kyu-Sik; Bo-Hee, Lee; Seo, Heenam; Chae, Soo-Wan; Chae, Han‐Jung

doi:10.4067/s0716-97602012000400013

Cited by 21 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endoplasmic reticulum (ER) stress signaling was also involved in the Aβ-induced microglial activation and apoptosis. Lee et al ( 2012 ) found that the anti-apoptotic ER stress protein glucose-regulated protein 78 (GRP78), a marker for enhanced protein folding machinery, was decreased in Aβ-stimulated microglial cells, while pretreatment of gastrodin increased the expression of GRP78, revealing the protective effects of gastrodin was possibly achieved through the enhancement of protein folding machinery, thus attenuating the neurotoxic activities of microglial cells. Li and Qian ( 2016 ) found gastrodin could not only counteract Aβ 1 - 42 -triggered release of pro-inflammatory cytokines and nitric oxide (NO), but also attenuate Aβ 1 - 42 -induced apoptosis in primary neural progenitor cells (NPCs), and these effects were associated with the inhibition of MEK1/2 and JNK expressions.…”

Section: Effects Of Gastrodin On Cns Diseasesmentioning

confidence: 99%

A Review on Central Nervous System Effects of Gastrodin

et al. 2018

View full text Add to dashboard Cite

Rhizoma Gastrodiae (also known as Tian ma), the dried rhizome of Gastrodia elata Blume, is a famous Chinese herb that has been traditionally used for the treatment of headache, dizziness, spasm, epilepsy, stoke, amnesia and other disorders for centuries. Gastrodin, a phenolic glycoside, is the main bioactive constituent of Rhizoma Gastrodiae. Since identified in 1978, gastrodin has been extensively investigated on its pharmacological properties. In this article, we reviewed the central nervous system (CNS) effects of gastrodin in preclinical models of CNS disorders including epilepsy, Alzheimer's disease, Parkinson's disease, affective disorders, cerebral ischemia/reperfusion, cognitive impairment as well as the underlying mechanisms involved and, where possible, clinical data that support the pharmacological activities. The sources and pharmacokinetics of gastrodin were also reviewed here. As a result, gastrodin possesses a broad range of beneficial effects on the above-mentioned CNS diseases, and the mechanisms of actions include modulating neurotransmitters, antioxidative, anti-inflammatory, suppressing microglial activation, regulating mitochondrial cascades, up-regulating neurotrophins, etc. However, more detailed clinical trials are still in need for positioning it in the treatment of neurological disorders.

show abstract

Section: Effects Of Gastrodin On Cns Diseasesmentioning

confidence: 99%

A Review on Central Nervous System Effects of Gastrodin

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A previous study demonstrated the neuroprotective effect of GE rhizome chloroform extract in vitro using rat pheochromocytoma (PC12) cells incubated with A β 1–42 [ 45 ]. In addition, methanol extract of GE rhizome and its pure components, gastrodin and 4-HBA, have been shown to have protective effects against A β -induced cell death in BV2 microglial cells, possibly through upregulation of glucose-regulated protein 78 (Grp78), an antiapoptotic endoplasmic reticulum (ER) stress protein related to protein-folding machinery [ 48 ].…”

Section: Protective Effects Of Ge and Its Components In Neurodegenmentioning

confidence: 99%

Neuropharmacological Potential ofGastrodia elataBlume and Its Components

Jang

Son

Kang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Research has been conducted in various fields in an attempt to develop new therapeutic agents for incurable neurodegenerative diseases. Gastrodia elata Blume (GE), a traditional herbal medicine, has been used in neurological disorders as an anticonvulsant, analgesic, and sedative medication. Several neurodegenerative models are characterized by oxidative stress and inflammation in the brain, which lead to cell death via multiple extracellular and intracellular signaling pathways. The blockade of certain signaling cascades may represent a compensatory therapy for injured brain tissue. Antioxidative and anti-inflammatory compounds isolated from natural resources have been investigated, as have various synthetic chemicals. Specifically, GE rhizome extract and its components have been shown to protect neuronal cells and recover brain function in various preclinical brain injury models by inhibiting oxidative stress and inflammatory responses. The present review discusses the neuroprotective potential of GE and its components and the related mechanisms; we also provide possible preventive and therapeutic strategies for neurodegenerative disorders using herbal resources.

show abstract

“…Studies utilizing a green fluorescent/Grp78 fusion protein reported targeting to mitochondria within a short period of ischemia-like stress [ 86 ]. Overexpression of Grp78 in BV2 mouse microglial cell lines [ 102 ] and astrocytes protected against ischemic injury and preserved respiratory activity and mitochondrial membrane potential after ischemic stress [ 103 ]. Pharmacological induction of Grp78 reduced neuronal loss in both forebrain and focal cerebral ischemia [ 104 , 105 ].…”

Section: Hsp70 and Bcl2 In Mitochondrial Homeostasismentioning

confidence: 99%

Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs

Stary

2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. MicroRNAs (miRs) are important posttranscriptional regulators of gene expression that function by inhibiting the translation of select target genes. In astrocytes, miR expression patterns regulate mitochondrial function in response to oxidative stress via targeting of Bcl2 and heat shock protein 70 family members. Mitochondria play an active role in microglial activation, and miRs regulate the microglial neuroinflammatory response. As endogenous miR expression patterns can be altered with exogenous mimics and inhibitors, miR-targeted therapies represent a viable intervention to optimize glial mitochondrial function and improve clinical outcome following cerebral ischemia. In the present article, we review the role that astrocytes and microglia play in neuronal function and fate following ischemic stress, discuss the relevance of mitochondria in the glial response to injury, and present current evidence implicating miRs as critical regulators in the glial mitochondrial response to cerebral ischemia.

show abstract

Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: The involvement of GRP78 and CHOP

Abstract: This study reveals the protective effects of GE against β-amyloid-induced cell death, possibly through the enhancement of protein folding machinery of a representative protein, GRP78, and the regulation of CHOP in BV2 mouse microglial cells.

Cited by 21 publications

References 20 publications

A Review on Central Nervous System Effects of Gastrodin

A Review on Central Nervous System Effects of Gastrodin

Neuropharmacological Potential ofGastrodia elataBlume and Its Components

Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs

Contact Info

Product

Resources

About