Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines

Liu, Zeyuan; Wang, Shuang; Zhang, Junshi; Wang, Yashuo; Wang, Yunyang; Zhang, Lina; Zhang, Li; L, Li; Dong, Jing; Wang, Bin

doi:10.1016/j.intimp.2019.105699

Cited by 17 publications

(17 citation statements)

References 41 publications

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“…The amount of the formazan dye, generated by the activities of dehydrogenases in cells, is directly proportional to the number of living cells. Based on this principle, the CCK-8 assay has been widely used to infer the toxicity of biomaterials in vitro. , A commercially available CCK-8 kit (40203ES60-100T, Yeasen Biotech Co., Ltd., Shanghai, China) was used in this study. The primary human fibroblast cell line was employed in the tests.…”

Section: Materials and Methodsmentioning

confidence: 99%

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Template-Assisted Magnetron Sputtering of Cotton Nonwovens for Wound Healing Application

Liu

Zhang

et al. 2019

ACS Appl. Bio Mater.

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In the present study, three kinds of functional wound dressings (Zn@Cotton, Ag@Cotton, and Ag/Zn@Cotton) were developed by template-assisted magnetron sputtering of cotton nonwovens. Scanning electron microscopy and energy dispersive spectrometry revealed a very thin, uniform silver oxides and zinc coating on the cotton cellulose microfibers, which was further confirmed by X-ray diffraction pattern, X-ray photoelectron spectrometry, and thermal gravimetric analysis. The physical characteristics such as high swelling ability, moderate air and water vapor permeabilities, good mechanical properties, and excellent flexibility support the suitability of magnetron sputtering cotton nonwovens for wound dressing applications. Moreover, the Ag/Zn@Cotton showed effective antibacterial activities against Escherichia coli and Staphylococcus aureus, which was mainly attributed to the synergistic effect of electrical stimulation and continuous release of Ag+/Zn2+. Meanwhile, benefiting from the low metal coating area percentage (17.54%), the Ag/Zn@Cotton exhibited good cytocompatibility. The in vitro and in vivo test show that Ag/Zn@Cotton can remarkably accelerate the wound healing process, which can be attributed to the enhanced cellular migration by electrical stimulation, strong antibacterial activity, good cytocompatibility, and excellent physical properties. Potentially, template-assisted magnetron sputtering may provide a simple, green, and sustainable alternative for the development of functional wound dressings.

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Section: Materials and Methodsmentioning

confidence: 99%

“…Based on this principle, the CCK-8 assay has been widely used to infer the toxicity of biomaterials in vitro. 37,38 A commercially available CCK-8 kit (40203ES60-100T, Yeasen Biotech Co., Ltd., Shanghai, China) was used in this study. The primary human fibroblast cell line was employed in the tests.…”

Section: Methodsmentioning

confidence: 99%

Template-Assisted Magnetron Sputtering of Cotton Nonwovens for Wound Healing Application

Liu

Zhang

et al. 2019

ACS Appl. Bio Mater.

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“…This suggested that TCM may promote the immunogenicity of vaccines in RA patients. It is well known that vaccines composed of antigens alone can only stimulate weak immunogenicity and TCM ingredients can be used as adjuvant to enhance the immunogenicity of the antigens ( 25 , 26 ). Recent studies have found that TCM polysaccharides can regulate the immune response by activating the signal pathway of natural killer cells, T/B lymphocytes, complement system, and so on ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 99%

Third dose of anti-SARS-CoV-2 inactivated vaccine for patients with RA: Focusing on immunogenicity and effects of RA drugs

et al. 2022

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ObjectivesTo evaluate the immunogenicity of the third dose of inactivated SARS-CoV-2 vaccine in rheumatoid arthritis (RA) patients and explore the effect of RA drugs on vaccine immunogenicity.MethodsWe recruited RA patients (n = 222) and healthy controls (HC, n = 177) who had been injected with a third dose of inactivated SARS-CoV-2 vaccine, and their neutralizing antibody (NAb) titer levels were assessed.ResultsRA patients and HC were age- and gender-matched, and the mean interval between 3rd vaccination and sampling was comparable. The NAb titers were significantly lower in RA patients after the third immunization compared with HC. The positive rate of NAb in HC group was 90.4%, while that in RA patients was 80.18%, and the difference was significant. Furthermore, comparison of NAb titers between RA treatment subgroups and HC showed that the patients in the conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) group exhibited no significant change in NAb titers, while in those receiving the treatment of biological DMARDs (bDMARDs), Janus Kinase (JAK) inhibitors, and prednisone, the NAb titers were significantly lower. Spearman correlation analysis revealed that NAb responses to SARS-CoV-2 in HC did differ significantly according to the interval between 3rd vaccination and sampling, but this finding was not observed in RA patients. In addition, NAb titers were not significantly correlated with RA-related laboratory indicators, including RF-IgA, RF-IgG, RF-IgM, anti-CCP antibody; C-RP; ESR; NEUT% and LYMPH%.ConclusionSerum antibody responses to the third dose of vaccine in RA patients were weaker than HC. Our study will help to evaluate the efficacy and safety of booster vaccination in RA patients and provide further guidance for adjusting vaccination strategies.

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“…The expression levels of perforin and TNF-a were increased by GAS + cell treatment compared with control group, and cytotoxic lymphocytes were significantly increased in mice immunized with GAS, which suggested that GAS can promote the responses of CD8 + T cells by enhancing T-cell proliferation and inflammation cytokine expression. Liu Z et al (27) demonstrated the immunogenicity of GAS as an adjuvant in an anti-melanin vaccine when they found that GAS enhanced the activation of antigen-presenting cells (APCs) -both in vivo and in vitro.…”

Section: Cd8 + T Cellsmentioning

confidence: 99%

Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment

Sun

Wang

et al. 2022

Front. Oncol.

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Traditional Chinese medicine (TCM), including herbal medicine, acupuncture and meditation, has a wide range of applications in China. In recent years, herbal compounding and active ingredients have been used to control tumor growth, reduce suffering, improve quality of life, and prolong the life span of cancer patients. To reduce side effects, herbal medicine can be used in conjunction with radiotherapy and chemotherapy or can be used as an adjuvant to strengthen the immune effect of anticancer vaccines. In particular, in the immunosuppressed tumor microenvironment, herbal medicine can have antitumor effects by stimulating the immune response. This paper reviews the advances in research on antitumor immunomodulation in Chinese herbal medicine, including the regulation of the innate immune system, which includes macrophages, MDSCs, and natural killer cells, and the adaptive immune system, which includes CD4+ T cells, CD8+ T cells, and regulatory T cells (Tregs), to influence tumor-associated inflammation. In addition, a combination of active ingredients of herbal medicine and modern nanotechnology alter the tumor immune microenvironment. In recent years, immunological antitumor therapy in TCM has been applied on a reasonably large scale both nationally and internationally, and there is potential for further clinical expansion. Investigation of immune modulation mechanisms in Chinese herbal medicine will provide novel perspectives of how herbal medicine controls tumor growth and metastasis, which will contribute to the evolution of tumor research.MethodologyExperimental research between the years of 2012-2022, meta-analysis and reviews for the period 2002-2022 found on the Databases including PubMed, Embase, and the Cochrane database were used. The inclusion criteria were experimental research literature addressing the anti-tumor immunological effects of active ingredients and nanoparticles in Chinese herbal medicine. Exclusion criteria were articles that addressed Chinese herbal medicine and nano-formulations without discussing anti-tumor immunological effects in innate, adaptive immune cells, MDSCs, and nuclear factors.

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Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines

Cited by 17 publications

References 41 publications

Template-Assisted Magnetron Sputtering of Cotton Nonwovens for Wound Healing Application

Template-Assisted Magnetron Sputtering of Cotton Nonwovens for Wound Healing Application

Third dose of anti-SARS-CoV-2 inactivated vaccine for patients with RA: Focusing on immunogenicity and effects of RA drugs

Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment

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