Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage

Liu, Xi-chang; Wu, Chang-zhu; Hu, Xiaofei; Wang, Tingling; Jin, Xiaoping; Ke, Shaofa; Wang, En; Wu, Gang

doi:10.1016/j.jstrokecerebrovasdis.2019.104483

Cited by 42 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Danhong-a traditional Chinese medicine extracted from 2 herbs (Salviae miltiorrhiza Bunge (Danshen, China) and Carthamus tinctorius L (Honghua, China))-contains flavonoids and phenolic compounds and was reported to increase the expression of peroxiredoxin (Prx) 1 in astrocytes, thereby preventing severe brain injury following ICH in aged rats [102]. In addition, carnosine [103], COA-Cl (a novel synthesized nucleoside analog) [104], AE1-259-01 EP2 receptor agonists [105], green tea and red tea [57], protocatechuic acid (PCA) [106], nebivolol [107], 14Adiponectin (APN) [108], metformin [109], C1q/tumor necrosis factor-related protein 3 (CTRPs) [15], gastrodin [110], Naringin (NGN) [111], and Parthenolide (PN) [112] are all effective antioxidants in ICH animal models.…”

Section: Peroxisome Proliferator-activated Receptor (Ppar) γmentioning

confidence: 99%

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Yao

Bai

Wang

2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury.

show abstract

Section: Peroxisome Proliferator-activated Receptor (Ppar) γmentioning

confidence: 99%

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Yao

Bai

Wang

2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…In addition, considering the low proportion of patients with thrombolytic treatment and lacunar stroke, it seemed that the mortality (2.0%) in our study was relatively low, which may be due to the relatively short follow-up time. Additionally, the application of Argatroban injection [12] and Chinese patent medicine injection (such as Diterpene ginkgolides meglumine injection [13] and gastrodin injection [14]) may contribute to ischemic injury and the short-term prognosis of patients.…”

Section: Plos Onementioning

confidence: 99%

The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke

et al. 2020

View full text Add to dashboard Cite

Background We aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), platelet-to-white blood cell ratio (PWR) and 90-day mortality in patients with acute ischemic stroke (AIS). Methods We retrospectively included 633 patients with AIS from January 2017 to May 2018. The correlation between each indicator and the degree of neurologic deficit was assessed. Kaplan-Meier survival curves based on blood cell ratios were used to analyze the 90-day survival rate of patients with AIS. Results A total of 663 patients with AIS were enrolled, of which 24 (3.6%) experienced recurrence and 13 (2.0%) died. NLR>3.23 (odds ratio; OR = 2.236; 95% confidence interval [CI], 1.472-3.397; P<0.001), PNR<31.14 (OR = 0.471; 95% CI, 0.297-0.749; P = 0.001), and PWR<20.62 (OR = 0.498; 95% CI, 0.309-0.800; P = 0.004) were associated with an unfavorable 90-day prognosis. NLR>3.23, PWR<20.62, and PNR<31.14 were associated with an increased risk of 90-day mortality. Conclusion PNR, PWR, and NLR were associated with the 90-day mortality of patients with AIS. Patients with high NLRs or low PWRs and PNRs may have a greater risk of mortality than other patients. These clinical indicators may help clinicians judge unfavorable prognosis early and implement the appropriate interventions.

show abstract

“…In line with the antioxidant action, GAS upregulated Keap1/Nrf2/HO-1 after 72 h. At the same time, GAS exerted an anti-apoptotic action in the perihematoma area. Also in vitro GAS exerted protective effects, being able to reduce the apoptosis caused by hematoma lysate in cortical neurons [ 115 ].…”

Section: Natural Compounds As Modulator Of Nrf2 Pathway In Stroke mentioning

confidence: 99%

Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?

Gugliandolo

Bramantı

Mazzon

2020

IJMS

View full text Add to dashboard Cite

Stroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis. In stress conditions, Nrf2 translocates inside the nucleus and induces the transcription of enzymes involved in counteracting oxidative stress, endobiotic and xenobiotic metabolism, regulators of inflammation, and others. Different natural compounds, including food and plant-derived components, were shown to be able to activate Nrf2, mediating an antioxidant response. Some of these compounds were tested in stroke experimental models showing several beneficial actions. In this review, we focused on the studies that evidenced the positive effects of natural bioactive compounds in stroke experimental models through the activation of Nrf2 pathway. Interestingly, different natural compounds can activate Nrf2 through multiple pathways, inducing a strong antioxidant response associated with the beneficial effects against stroke. According to several studies, the combination of different bioactive compounds can lead to a better neuroprotection. In conclusion, natural bioactive compounds may represent new therapeutic strategies against stroke.

show abstract

Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage

Cited by 42 publications

References 41 publications

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke

Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?

Contact Info

Product

Resources

About