Gastrodin destabilizes survivin and overcomes pemetrexed resistance

Liao, Jinzhuang; Qiu, Xiang; Deng, Guanghui; Xiao, Yuzhong; Fu, Yaqian; Han, Shuangze; Lü, Xiaoying; Gan, Yu; Li, Wei

doi:10.1016/j.cellsig.2023.110851

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…These findings suggest that gastrodin elicits anti-tumor effects by activating endogenous apoptosis signals in NSCLC cells. [75] Overall, these studies provided evidence of gastrodin's potential application as an anti-cancer agent, while additional investigation is needed to completely comprehend its mechanisms of action and potential clinical applications. Gastrodin's ability to inhibit cancer growth, enhancement of immune response, regulation of autophagy, and alleviation of cancerinduced pain suggested its potential development as a drug lead against cancer.…”

Section: Mts Analysismentioning

confidence: 98%

“…Reduction of 90 % cell viability at 40 μM [75] In the same year, Huwa et al [74] established that gastrodin significantly impedes the proliferation of the prostate cancer cell lines PC3 and DU145. The oral administration of gastrodin notably retards the subcutaneously injected tumor growth of PC3 cells.…”

Section: Mts Analysismentioning

confidence: 99%

“…These findings suggest a potential role for gastrodin in prostate cancer treatment by targeting the canonical Wnt/β-Catenin signaling pathway. [74] Finally, a study by Hia et al, [75] utilized MTS analysis to reveal that gastrodin reduces the viability of non-small cell lung cancer (NSCLC) cells in a dose-and time-dependent manner. Following 24 hours of 40 μM gastrodin treatment, cell viability was reduced by over 50 %.…”

Section: Mts Analysismentioning

confidence: 99%

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Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

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Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.

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Section: Mts Analysismentioning

confidence: 98%

Section: Mts Analysismentioning

confidence: 99%

Section: Mts Analysismentioning

confidence: 99%

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Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

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“…Recent studies have also revealed the promising anti-tumor effects of gastrodin. Liao et al suggested that gastrodin may serve as a potential antitumor agent by reducing survivin levels in non-small-cell lung cancer [8]. Additionally, Shu et al demonstrated that gastrodin effectively suppressed the growth of transplanted H22 ascitic hepatic tumor cells in vivo, exhibiting minimal toxicity [9].…”

Section: Introductionmentioning

confidence: 99%

Gastrodin Induces Ferroptosis of Glioma Cells via Upregulation of Homeobox D10

Cao,

Lan,

Zeng

et al. 2023

Molecules

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Gastrodin, the primary bioactive compound found in Gastrodia elata, has been shown to exhibit neuroprotective properties in a range of neurological disorders. However, the precise mechanisms through which gastrodin influences glioma cells remain unclear, and there is a scarcity of data regarding its specific effects. To ascertain the viability of glioma cell lines LN229, U251, and T98, the CCK-8 assay, a colony formation assay, and a 3D culture model were employed, utilizing varying concentrations of gastrodin (0, 5, 10, and 20 μM). Gastrodin exhibited a notable inhibitory effect on the growth of glioma cells, as evidenced by its ability to suppress colony formation and spheroid formation. Additionally, gastrodin induced ferroptosis in glioma cells, as it can increase the levels of reactive oxygen species (ROS) and peroxidized lipids, and reduced the levels of glutathione. Using a subcutaneous tumor model, gastrodin was found to significantly inhibit the growth of the T98 glioma cell line in vivo. Using high-throughput sequencing, PPI analysis, and RT-qPCR, we successfully identified Homeobox D10 (HOXD10) as the principal target of gastrodin. Gastrodin administration significantly enhanced the expression of HOXD10 in glioma cells. Furthermore, treatment with gastrodin facilitated the transcription of ACSL4 via HOXD10. Notably, the inhibition of HOXD10 expression impeded ferroptosis in the cells, which was subsequently restored upon rescue with gastrodin treatment. Overall, our findings suggest that gastrodin acts as an anti-cancer agent by inducing ferroptosis and inhibiting cell proliferation in HOXD10/ACSL4-dependent pathways. As a prospective treatment for gliomas, gastrodin will hopefully be effective.

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