Gastrodin Inhibits Virus Infection by Promoting the Production of Type I Interferon

Zhou, Yunlian; Li, Mengyao; Lv, Tingyi; Huang, Min; Cheng, Bin; Zhang, Yuanyuan; Zhu, Jie

doi:10.3389/fphar.2020.608707

Cited by 12 publications

(3 citation statements)

References 45 publications

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“…G. elata has many pharmacological effects ( Wang et al., 2021b ; Zhou et al., 2021a ) and contains over 200 bioactive components and plant secondary metabolites, such as gastrodin (4-hydroxy methyl phenyl-β-D-glucopyranoside), gastrodigenin (p-hydroxybenzyl alcohol), p-hydroxybenzaldehyde, vanillin (4-hydroxy-3-methoxybenzaldehyde), parishin, G. elata polysaccharides, amino acids, and other compounds, which have been demonstrated to be the main components associated with the pharmacological activity of G. elata ( Yu et al., 2005 ; Kim et al., 2007 ; Chen et al., 2011b ). Among these, gastrodin and gastrodigenin are regarded as phytochemical indicators of G. elata in the Chinese pharmacopeia and are used in G. elata quality control ( Sun et al., 2023 ).…”

Section: Overview Of G Elata and Its Applicationsmentioning

confidence: 99%

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

Liu,

Yang,

et al. 2024

Front. Plant Sci.

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Gastrodia elata Blume, a fully mycoheterotrophic perennial plant of the family Orchidaceae, is a traditional Chinese herb with medicinal and edible value. Interestingly, G. elata requires symbiotic relationships with Mycena and Armillaria strains for seed germination and plant growth, respectively. However, there is no comprehensive summary of the symbiotic mechanism between fungi and G. elata. Here, the colonization and digestion of hyphae, the bidirectional exchange of nutrients, the adaptation of fungi and G. elata to symbiosis, and the role of microorganisms and secondary metabolites in the symbiotic relationship between fungi and G. elata are summarized. We comprehensively and deeply analyzed the mechanism of symbiosis between G. elata and fungi from three perspectives: morphology, nutrition, and molecules. The aim of this review was to enrich the understanding of the mutualistic symbiosis mechanisms between plants and fungi and lay a theoretical foundation for the ecological cultivation of G. elata.

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Section: Overview Of G Elata and Its Applicationsmentioning

confidence: 99%

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

Liu,

Yang,

et al. 2024

Front. Plant Sci.

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“…In a separate study, Artusa et al reported that green coffee and roasted coffee extract can inhibit the effect of IRF 3, thereby inhibiting excessive IFN-β-induced inflammation [ 104 ]. Conversely, during viral infection, gastrodin (GTD) can promote the activation of IRF 3 in macrophages to facilitate the production of IFN-Is, resisting inflammation and anti-viral infection [ 105 ]. Another significant pathway for the production of IFN-Is through IRF 3 is cGAS/ STING signaling.…”

Section: Type I Interferon Signaling In Inflammationmentioning

confidence: 99%

The crucial regulatory role of type I interferon in inflammatory diseases

Ji,

Li,

Chen

et al. 2023

Cell Biosci

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Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and periodontitis, impacting people's health and quality of life. It is well-established that IFN-Is affect immune responses and inflammatory factors by regulating some signaling. However, currently, there is no comprehensive overview of the crucial regulatory role of IFN-I in distinctive pathways as well as associated inflammatory diseases. This review aims to provide a narrative of the involvement of IFN-I in different signaling pathways, mainly mediating the related key factors with specific targets in the pathways and signaling cascades to influence the progression of inflammatory diseases. As such, we suggested that IFN-Is induce inflammatory regulation through the stimulation of certain factors in signaling pathways, which displays possible efficient treatment methods and provides a reference for the precise control of inflammatory diseases.

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“…It is highly contagious and zoonotic, frequently leading to vesicles and unclear on the tongue, papilla, or other positions. Although its morbidity is not so high, the injury is irreversible, then resulting in the enormous economic losses ( 1 , 2 ). VS is classified as a list B disease by Office International Des Epizooties (OIE), belonging to 1 of the 13 foreign diseases that need to be supervised in China.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

Shao

Huang

2021

Front. Vet. Sci.

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Viral disease management has been proven difficult, and there are no broadly licensed vaccines or therapeutics. Vesicular stomatitis virus (VSV) is an active pathogen of wild ungulates and livestock; its infection frequently caused irreversible vesicles on the tongue or other positions, leading to enormous economic loss. Tea tree oil (TTO) has been shown to be a popular remedy for many skin diseases owing to its antibacterial, antipruritic, and anti-inflammatory effects. However, the potential effect of TTO on VSV proliferation and the corresponding inflammatory response in cells remain unclear. In this study, methyl thiazolyl tetrazolium assay was used to evaluate the cell viability of TTO, and cytotoxic concentration 50 (CC50) was calculated. Then, fluorescence observation, reverse transcription–quantitative polymerase chain reaction, Western blot (WB), and flow cytometry (FCM) assay were used to evaluate the antiviral effect of TTO against VSV under three manners of pre-infection before medication, co-administration, pretreatment before infection at safe doses to Vero cells. Meanwhile, the mRNA expressions of interleukin 8, tumor necrosis factor α, and ISG56 in cells were also detected. The results showed that the maximum safe concentration of TTO to Vero cells was 0.063% and the CC50 is 0.32%. Most notably, TTO dose-dependently inhibited the VSV GFP fluorescence generation and restrained the replication of VSV in gene and protein levels regardless of the treatment modes. Based on the results of the FCM, effective concentration 50 of TTO against VSV is 0.019%. Similarly, the mRNA expression of the above cytokines induced by viral infection was also remarkably curbed. These findings suggest that TTO emerged blocking, prophylaxis, and treatment action against VSV replication and suppressed the related inflammation in Vero cells. This study provides a novel potential for TTO fighting against viral infection and anti-inflammatory activities in Vero cells.

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Gastrodin Inhibits Virus Infection by Promoting the Production of Type I Interferon

Cited by 12 publications

References 45 publications

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

The crucial regulatory role of type I interferon in inflammatory diseases

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

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