Gastroduodenal diseases on the Jos plateau, Nigeria

Malu, AO; Okeke, EN; Daniyam, Comfort A

doi:10.1016/0035-9203(94)90406-5

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…5,18,20 However, in this study, we used histology to detect H. Pylori and this seems to be in agreement with other studies that have used histology 21,22 rather than serology or stool antigen test. These latter methods are known to give higher values because of higher sensitivity rates.…”

Section: Articlesupporting

confidence: 92%

“…Similar results with a higher prevalence of gastric than duodenal ulcer had been reported in northeastern Nigeria; 6 these findings contrast with other studies that have shown the opposite tendency. 5,18 A little under half had essentially normal endoscopic findings such as to suggest nonulcer dyspepsia although histology revealed features of mild to moderate chronic gastritis in nearly all participants.…”

Section: Discussionmentioning

confidence: 98%

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A clinicopathological study of dyspeptic subjects in Lagos, Nigeria

Hameed

Onyekwere

Otegbayo

et al. 2012

Gastroenterol Insights

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The clinicopathological and endoscopic features of dyspepsia have not been well studied in Nigeria due to the high cost of gastroscopes and lack of the relevant expertise. This study was designed to highlight these features and possible risk factors. This prospective study was conducted on adult dyspeptic patients who fulfilled the study criteria from November 2007 to December 2008 at a University hospital in Lagos, Nigeria. Demographic and clinical presentation including possible risk factors were obtained through a questionnaire administered by an interviewer followed by an upper gastrointestinal endoscopy and gastric biopsy. Of the 123 subjects who took part in the study, 100 gave their consent to an upper gastrointestinal endoscopy and biopsy. The male:female ratio was 1:1, mean age was 44.98 (SD 15.4) years and the modal age group was 38-47years. The prevalence of dyspepsia was 29% and epigastric pain was the most common presentation. Endoscopic findings were superficial mucosal lesion (21%), peptic ulcer (16%), features of gastroesophageal reflux disease (10%), and gastric cancer (2%), as well normal findings (44%). Non-steroidal antiinflammatory drug (NSAID) use as a risk factor had a significant association with positive endoscopic findings; relative risk for development of positive endoscopic findings was 1.5% (P =0.03). Histology showed rates of chronic gastritis to be 91% and normal values 9%. The most common type of gastritis was the non-specific form (59.3%), followed by H. Pylori-associated gastritis (36.3%). The topography of gastritis was mainly pangastritis (68.1%) and antral predominant in 23.1%. The prevalence of H. pylori by histology was 41%. The presence of H. pylori was not associated with severity, location or duration of symptoms. H. pylori was, however, found to be a significant contributor to the development of positive endoscopic findings (P=0.01; OR 2.92 95% CI 1.50-3.17). Alarm symptoms were found to be important markers of malignancy. Dyspeptic illness is common,with peak incidence in the 4th decade of life and no gender predilection. Epigastric pain has the most discriminatory value with alarm symptoms in cases of gastric cancer. Risk factors such as NSAID use and H. pylori infection had a very significant impact on endoscopic findings while presence of H. pylori, smoking and alcohol consumption were associated with increased risk of developing chronic gastritis

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Section: Articlesupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

A clinicopathological study of dyspeptic subjects in Lagos, Nigeria

Hameed

Onyekwere

Otegbayo

et al. 2012

Gastroenterol Insights

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“…Most available information relating to the epidemiology of duodenal or gastric ulceration has been derived from hospital studies, but such population-based data as exist suggest that the prevalence of peptic ulceration is on the order of 1 to 2% in unselected adults (25). A high prevalence of gastroduodenal mucosal lesions has also been reported from Sudan (10) and Nigeria (19), but there is older evidence that prevalence may be low in some other countries, and there may be differences between rural and urban populations (26).…”

Section: Discussionmentioning

confidence: 89%

Helicobacter pylori Infection in an Urban African Population

et al. 2001

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We have studied 221 adults drawn from an impoverished urban population with high human immunodeficiency virus (HIV) seroprevalence (35%) to determine the prevalence of gastroduodenal pathology and its relationship to serological markers of Helicobacter pylori virulence proteins and other potential environmental and immunological determinants of disease including HIV infection. Eighty-one percent were H. pylori seropositive, and 35% were HIV seropositive. Urban upbringing and low CD4 count were associated with a reduced likelihood of H. pylori seropositivity, as was current Ascaris infection, in keeping with recent evidence from an animal model. One hundred ninety-one adults underwent gastroduodenoscopy, and 14 had gastroduodenal pathology. Mucosal lesions were a major cause of abdominal pain in this population. While the majority of patients with gastroduodenal pathology (12 of 14) were seropositive for H. pylori, none were seropositive for HIV. Smoking was associated with increased risk of macroscopic pathology, and a history of Mycobacterium bovis BCG immunization was associated with reduced risk. Antibodies to H. pylori lipopolysaccharide were associated with pathology. HIV infection was associated with protection against mucosal lesions, suggesting that fully functional CD4 lymphocytes may be required for the genesis of gastroduodenal pathology.

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“…The physicians commonly do a lot of upper gastrointestinal endoscopy 3,4,5 while the surgeons do more of the lower gastrointestinal tract 6,7,8 .We have encountered a some problems while beginning endoscopy in our setting Costs. It is by our standard still very expensive as it costs N15, 000 ($115) for upper GI endoscopy and is N17, 500 ($135) for lower GI endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Surgical gastrointestinal endoscopy in Ibadan, Nigeria

Irabor¹

2010

Nigerian Journal of Surgical Research

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Gastroduodenal diseases on the Jos plateau, Nigeria

Cited by 15 publications

References 8 publications

A clinicopathological study of dyspeptic subjects in Lagos, Nigeria

A clinicopathological study of dyspeptic subjects in Lagos, Nigeria

Helicobacter pylori Infection in an Urban African Population

Surgical gastrointestinal endoscopy in Ibadan, Nigeria

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