Gastroduodenal mucosa prostaglandins participate in realization of the effect of the antiulcer drug venter

Abstract

It is shown that in patients with ulcer disease endogenous biosynthesis of prostaglandins E and F2~ in gastric and duodenal mucosa is suppressed. In patients treated with Venter (sucralfat), ulcer healing is accompanied by enhanced prostaglandin production in both scar tissue and unaffected areas. Stimulation of prostaglandin E and F2, " synthesis in the gastroduodenal mucosa followed by activation of their cytoprotective effect in the gastrointestinal system is a key mechanism underlying the effect of Venter.