Gastroenterology

Selective Sensing of Ammonium Ion Over Other Biologically Important Ammonia Derivatives by a Coumarin‐Based ϵ‐Amino Ester

“…[3] Hence, the molecular recognition and sensing of ammonium ions may helpful for diagnosis of liver malfunction. [4] Considerable efforts have been undertaken to develop synthetic receptors for ammonium ion using crown ethers, calixarenes, porphyrins, cucurbit-urils, cyclodextrins and cyclopeptides to tweezer ligands, sterically geared tripods and several types of metal complexes exploiting intermolecular interactions such as hydrogen bonds, electro-static and cation-p interactions, hydrophobic interactions or reversible covalent bond formation. [5] Biocompatibility is one of the major issues for this kind of sensors having diagnosis and therapeutic potential.…”