Gastroenteropancreatic neuroendocrine tumors: Clinical characteristics, diagnosis and prognosis at Hospital Universitario Clínico San Carlos (Madrid)

Novoa, María Paz de Miguel; Capel, Francisco Fernandez; Sedano, Jesús Vicente Redondo; Carrera, Margarita; Jiménez, Verónica Aranda; Pereira, Paloma Ortiz; Valera, Javier Sastre; Medina, Luis Ortega; Pérez, José Ángel Díaz

doi:10.1016/j.endoen.2014.04.001

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Our data only included the Chinese population, and it is not clear whether the results could be generalized to populations worldwide. Second, additional known risk factors that could predict survival were not evaluated, including histological growth pattern, mitotic rate, Ki-67 index, and immunohistochemistry markers, such as chromogranin A (CgA) and synaptophysin (Syn) [21,[30][31][32][33]. Finally, our analysis did not adjust for treatment approaches that may impact outcomes [34].…”

Section: Discussionmentioning

confidence: 99%

“…The ratios of metastatic rectal NEN patients were 5% in the SEER database [9], 8% in the Japanese registry [12], and 11.6% in the current study. Given that distant metastasis was one of the strongest prognostic factors of outcome [12,[20][21][22][23][24], differences in overall survival were also noted between colonic NENs and rectal NENs. In the SEER database, colonic NEN patients exhibited the worst prognosis among all GEP-NENs patients, with a 5-year overall survival rate of 41.6%.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

Jiang

Yuan

2017

JCO

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Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size ( < 0.0001) and distant metastasis ( < 0.0001). Colonic NENs had a worse prognosis ( = 0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor ( = 0.081), but tumor size ( = 0.037) and pathological classification ( = 0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

Jiang

Yuan

2017

JCO

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Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms

Jiang

Tan

et al. 2017

Gastroenterology Research and Practice

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Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P < 0.0001) and distant metastasis (P < 0.0001). Colonic NENs had a worse prognosis (P = 0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor (P = 0.081), but tumor size (P = 0.037) and pathological classification (P = 0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.

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Gastroenteropancreatic neuroendocrine tumors: Clinical characteristics, diagnosis and prognosis at Hospital Universitario Clínico San Carlos (Madrid)

Cited by 2 publications

References 3 publications

Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms

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