Gastroenterostomy and Vagotomy in the Treatment of Duodenal Ulcer

Weinstein, Vernon A.; Druckerman, Leonard J.; Lyons, Albert S.; Colp, Ralph

doi:10.1097/00000658-195504000-00008

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…Both surgical cutting of nerves and injection of neurotoxic drugs have been used to study the effect of denervation in cancer. In humans, extrinsic vagal denervation, termed vagotomy, either unilateral or bilateral, was first used in the management of gastric and duodenal ulcers 27,28 . This treatment seemed to increase the risk of developing gastric cancer due to delayed gastric emptying and concomitant hypochlorhydria, which could increase the levels of N-nitroso compounds [29][30][31] .…”

Section: Denervationmentioning

confidence: 99%

Nerves in gastrointestinal cancer: from mechanism to modulations

Vaes

Idris

Boesmans

et al. 2022

Nat Rev Gastroenterol Hepatol

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Section: Denervationmentioning

confidence: 99%

Nerves in gastrointestinal cancer: from mechanism to modulations

Vaes

Idris

Boesmans

et al. 2022

Nat Rev Gastroenterol Hepatol

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“…That there has been a renewal of interest in vagotomy as a complementary procedure in both gastroenterostomy and subtotal gastrectomy and as a supplementary one in the alleviation of gastrojejunal ulcer is quite apparent from the plethora of articles appearing in most medical journals. This communication is concerned with (1) a few technical considerations that 1 believe to have been responsible for the lowered mortality and morbidity of subtotal gastrectomy, (2) had been completely or partially removed. If the clo¬ sure of the transected duodenum has been attended with difficulty and if there is an iota of doubt as to the security of the suture line, the area should be ade¬ quately drained, preferably through a right subcostal stab wound.…”

mentioning

confidence: 99%

Subtotal Gastrectomy With and Without Vagotomy for Duodenal and Gastrojejunaln Ulcer

Colp¹

1956

JAMA

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Delayed return of gastric emptying after gastroenterostomy

Woods

Mitchell

1989

Journal of British Surgery

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A retrospective study of patients having gastroenterostomies was undertaken to identify predictive factors for the development of postoperative delayed return of gastric emptying (DRGE). A total of 322 consecutive patients underwent 324 gastroenterostomies; 35 experienced delayed return of gastric emptying. Regression analysis demonstrated preoperative obstruction to be the most significant factor (P less than 0.001). Vagotomy was not an independent variable. Age, sex, size of stoma, anastomotic technique, albumin and experience of the operator were not significant factors. Gastroenterostomy in the presence of 'gastric atony' was likely to produce DRGE. In all, 86 per cent of cases resolved spontaneously. Only one case of DRGE was found to have a mechanical cause. Most patients were supported by parenteral nutrition but, with a knowledge of the identified risk factors, more thought could be given to establishing a route for jejunal feeding at the time of surgery.

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Gastroenterostomy and Vagotomy in the Treatment of Duodenal Ulcer

Cited by 7 publications

References 8 publications

Nerves in gastrointestinal cancer: from mechanism to modulations

Nerves in gastrointestinal cancer: from mechanism to modulations

Subtotal Gastrectomy With and Without Vagotomy for Duodenal and Gastrojejunaln Ulcer

Delayed return of gastric emptying after gastroenterostomy

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