Gastroesophageal Reflux After Sleeve Gastrectomy: New Onset and Effect on Symptoms on a Prospective Evaluation

Pilone, Vincenzo; Tramontano, Salvatore; Renzulli, Michele; Zulli, Claudio; Schiavo, Luigi

doi:10.1007/s11695-019-04046-5

Cited by 26 publications

(14 citation statements)

References 27 publications

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“…Preoperative evaluation included anthropometric measurements (height in cm, weight in kg, BMI in kg/m 2 ), comorbidity evaluation [glycated hemoglobin (A1c), C-peptide, stimulated C-peptide, electrocardiography (ECG), echocardiography, lower limbs US color-Doppler study, thyroid function profile]. All patients were evaluated for the presence/absence of GERD before surgery and were surveyed about the presence of heartburn and/or regurgitation with the GERD HRQL questionnaire [6]. In this latter, each of the 10 questions was rated from 0 (absence of symptoms) to 5 (severe symptoms) for a total score that may range from 0 to 50.…”

Section: Preoperative Evaluationmentioning

confidence: 99%

Does antrum size matter in sleeve gastrectomy? A prospective randomized study

Pizza¹,

D’Antonio²,

Lucido

et al. 2020

Surg Endosc

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Background Laparoscopic sleeve gastrectomy (LSG) is a safe and effective bariatric procedure in terms of excess weight loss. Nevertheless, controversies still exist on several technical and operative aspects of LSG. The aim of this study is to evaluate variations in anthropometric features in subjects with a LSG gastric resection starting from 2 cm or 6 cm from the pylorus. Secondary aim was the evaluation of differences in morbidity, food tolerance, and GERD incidence studied with upper endoscopy (UE) and GERD Health-Related Quality-of-Life score. Methods Patients were prospectively randomized into 2 groups: Group A (at 2 cm proximally to the pylorus) and Group B (at 6 cm proximally to the pylorus). All patients were followed-up at 3, 6, 12, and 24 months. UE was performed in all patients at 12 or 24 months. Results One hundred and fifty met the inclusion criteria and were enrolled in the study. The anthropometric features (BMI,

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Section: Preoperative Evaluationmentioning

confidence: 99%

Does antrum size matter in sleeve gastrectomy? A prospective randomized study

Pizza¹,

D’Antonio²,

Lucido

et al. 2020

Surg Endosc

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“…Conflicting studies: likely worsens reflux. [55][56][57][58][59][60][61][62][63] SM-BOSS trial with 5-year follow-up showed worsening reflux. 61 Division of diaphragmatic crural ligaments and disruption of angle of His resulting in lower LES pressures.…”

Section: Restrictivementioning

confidence: 96%

“…58 Another study of 222 patients undergoing SG showed that 52.0% of patients complained of postoperative GERD symptoms, of which 73.0% were de novo. 59 Also, of concern is an increase in post-operative asymptomatic reflux, as described by Pilone et al 60 Studies assessing long-term outcomes of SG have offered further evidence of worsening GERD symptoms. The Swiss Multicenter Bypass or Sleeve Study trial evaluated 5-year postoperative outcomes of SG versus RYGB.…”

Section: Laparoscopic Sleeve Gastrectomymentioning

confidence: 99%

The Effect of Bariatric Surgery and Endoscopic Procedures on Gastroesophageal Reflux Disease

Fass

Mashimo

2021

J Neurogastroenterol Motil

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“…Each item is scored on a 6-point scale, from 0 to 5 points. A score of 0 indicates no symptoms, and a score of 5 indicates that symptoms are incapacitating when performing daily activities [40,41].…”

Section: Primary Outcomesmentioning

confidence: 99%

Traditional Chinese Medicine Based On Tongjiang Methodology Combined With Proton Pump Inhibitors (PPIs) De-Escalation In Treating Non-Erosive Reflux Disease: A Study Protocol For A Multicentred, Randomized Controlled Clinical Trial

Chen

et al. 2021

Preprint

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Background: Non-erosive reflux disease (NERD) is characterized by typical gastroesophageal reflux symptoms, such as heartburn and regurgitation, but an absence of oesophageal mucosal damage during upper gastrointestinal endoscopy. Although proton pump inhibitors (PPIs) are the first line therapy, almost 50% of patients with NERD fail to respond to this treatment. Traditional Chinese medicine (TCM) can better relieve the symptoms of NERD. Therefore, a randomized controlled trial (RCT) was designed to investigate the efficiency of TCM granules based on Tongjiang (TJ) methodology combined with PPIs de-escalation therapy for NERD patients who did not respond to PPIs alone. Method: This multicentred, double-blinded, RCT with two parallel groups will recruit 174 participants who will be randomized into the TCM granules combined with PPIs de-escalation group (n=87) and the TCM granules placebo combined with PPIs de-escalation group (n=87). Both groups of participants will receive 6 weeks of treatment and 4 weeks of follow-up, and all participants will be assessed for related symptoms, mental health status and quality of life at each visit. The primary outcome measurements include Visual Analogue Scale (VAS) for heartburn and regurgitation and the major symptoms scale. The secondary outcome measurements include PPI withdrawal rate, symptom recurrence rate, minor symptoms scale, SF-36, PRO, SAS, SDS, GERD–HRQL and TCM syndromes scales.Discussion: Previous research has shown that TCM is capable to alleviate NERD symptoms. This trial will help to provide a better understanding of the synergistic efficiency of the combination of TCM and PPIs, to explore whether the dosage of PPIs can be reduced after the supplement of TCM granules and to provide a feasible plan to reduce dependencies or withdraw NERD patients from PPIs. The outcome of this trial is expected to reduce the symptom recurrence rates, lessen patients’ physical and psychological burdens, and achieve good social benefits.Trial registration number: Clinicaltrials.gov: NCT04340297

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Gastroesophageal Reflux After Sleeve Gastrectomy: New Onset and Effect on Symptoms on a Prospective Evaluation

Cited by 26 publications

References 27 publications

Does antrum size matter in sleeve gastrectomy? A prospective randomized study

Does antrum size matter in sleeve gastrectomy? A prospective randomized study

The Effect of Bariatric Surgery and Endoscopic Procedures on Gastroesophageal Reflux Disease

Traditional Chinese Medicine Based On Tongjiang Methodology Combined With Proton Pump Inhibitors (PPIs) De-Escalation In Treating Non-Erosive Reflux Disease: A Study Protocol For A Multicentred, Randomized Controlled Clinical Trial

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