Gastroesophageal Reflux, Atopic Dermatitis, and Asthma: Finally Evidence for Causal Links?

Althoff, Meghan D.; Sharma, Sunita

doi:10.1164/rccm.202210-1953ed

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…GERD is common among people with asthma and can worsen and trigger asthma attacks. Treating GERD improves the respiratory symptoms of asthma patients [ 40 ]. Possible GERD–asthma symptoms include reflux-related respiratory issues, worsened asthma after meals or lying down, nocturnal asthma, and poor responses to bronchodilators [ 41 ].…”

Section: Gerd Overviewmentioning

confidence: 99%

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)

Herdiana

2023

Nutrients

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Gastroesophageal reflux disease (GERD) is a common esophageal disorder characterized by troublesome symptoms associated with increased esophageal acid exposure. The cornerstones of therapy in this regard include treatment with acid-suppressive agents, lifestyle modifications, and dietary therapy, although the latter has not been well defined. As concerns regarding long-term proton pump inhibitor (PPI) use continue to be explored, patients and healthcare providers are becoming increasingly interested in the role of diet in disease management. However, dietary interventions lack evidence of the synthesis effect of functional foods. The following is a review of dietary therapy for GERD, emphasizing food components’ impact on GERD pathophysiology and management. Although the sequential dietary elimination of food groups is a common practice, the literature supports broader intervention, including reduced overall sugar intake, increased dietary fiber, and changes in overall eating practices. While the primary concern of food companies is to provide safe products, the caloric, nutritional, and functional composition of foods is also generating interest in the food industry due to consumers’ concerns.

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Section: Gerd Overviewmentioning

confidence: 99%

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)

Herdiana

2023

Nutrients

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“…Among the instrumental variables (IVs) representing gastrointestinal diseases, SNPs related to smoking, asthma, and lung function will be excluded. Previous research has also indicated an increased risk of gastrointestinal diseases with asthma (Althoff and Sharma, 2023), and both gastrointestinal diseases and COPD are susceptible to the influence of smoking (Berkowitz et al, 2018;Maret-Ouda et al, 2020b). Therefore, when selecting IVs for COPD, SNPs related to smoking and asthma will be excluded.…”

Section: Instrumental Variablesmentioning

confidence: 99%

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Shen,

Qiu,

Chen

et al. 2023

Front. Genet.

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Background: Observational studies suggest an association between gastrointestinal diseases and chronic obstructive pulmonary disease (COPD), but the causal relationship remains unclear.Methods: We conducted bidirectional Mendelian randomization (MR) analysis using summary data from genome-wide association study (GWAS) to explore the causal relationship between common gastrointestinal diseases and COPD. Gastrointestinal diseases included gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), irritable bowel syndrome (IBS), Crohn’s disease (CD), ulcerative colitis (UC), functional dyspepsia (FD), non-infectious gastroenteritis (NGE), and constipation (CP). Significant MR analysis results were replicated in the COPD validation cohort.Results: Bidirectional MR analysis supported a bidirectional causal relationship between GERD and COPD, and COPD was also found to increase the risk of IBS and CP. Our study also provided evidence for a bidirectional causal relationship between PUD and COPD, although the strength of evidence may be insufficient. Furthermore, we provided evidence that there is no causal association between CD, UC, FD, NGE, and COPD.Conclusion: This study offers some evidence to clarify the causal relationship between common gastrointestinal diseases and COPD. Further research is needed to understand the underlying mechanisms of these associations.

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“… 121 Although GERD and DA are associated, its precise processes are yet unknown. 122 The effect of GERD medication on asthma outcomes in both adults and children is still debatable. The addition of lansoprazole, a proton-pump inhibitor, as compared to a placebo, did not improve symptoms or lung function in children with poorly controlled asthma who were using ICS but was associated with an increase in adverse events.…”

Section: Evaluation and Management Of Damentioning

confidence: 99%

Progress in diagnosis and treatment of difficult-to-treat asthma in children

Zhou,

Zhang,

Tan

et al. 2023

Ther Adv Respir Dis

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At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as ‘children with difficult-to-treat asthma (DA)’. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children’s health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA. This article reviews the definition, evaluation, and treatment of this asthma in order to provide a reference for optimal clinical decision-making.

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Gastroesophageal Reflux, Atopic Dermatitis, and Asthma: Finally Evidence for Causal Links?

Cited by 4 publications

References 15 publications

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Progress in diagnosis and treatment of difficult-to-treat asthma in children

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