Gastroesophageal Reflux Contributing to Chronic Sinus Disease in Children

Cd, Phipps; We, Wood; Ws, Gibson; Wj, Cochran

doi:10.1001/archotol.126.7.831

Cited by 181 publications

(157 citation statements)

References 16 publications

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“…[15] DiBaise et al showed a higher number 81.8% of patients with CRS had reflux disease [16] and Phipps et al had reported 63% of patients with CRS had reflux. [17] Foreign body sensation in throat was the most common symptom, and posterior laryngeal congestion was the most common sign in our study [ Table 2]. Ulualp et al also found signs of posterior laryngitis in patients with refractory CRS.…”

Section: Discussionsupporting

confidence: 65%

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Correlation between chronic rhinosinusitis and laryngopharyngeal reflux

Nanda¹,

Kaur²,

Gupta³

2017

Natl J Physiol Pharm Pharmacol

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Background: Chronic rhinosinusitis (CRS) is a major Ear, Nose and Throat disease and there are higher numbers of refractory cases poorly responding to medical and surgical treatment. Laryngopharyngeal reflux (LPR) is said to be the important cause for same. Aims and Objectives: This study aims to study the incidence of LPR in patients of refractory CRS. This study also aims to study the impact of proton pump inhibitors (PPI) (effective treatment of LPR) given as adjuvant therapy along with functional endoscopic sinus surgery (FESS) in patients with refractory CRS. Materials and Methods: A total of 40 patients of refractory CRS taken up for the study were evaluated for signs and symptoms of LPR. They were then divided into two groups of 20 each -study group and control group. All the patients in both groups were evaluated for signs and symptoms of CRS. All these patients underwent FESS. Post-surgery patients in the study group were given intranasal steroids (INS) along with PPI (tablet pantoprazole) whereas in control group were put on INS without PPI. The patients were followed monthly for 3 months for improvement in signs and symptoms of CRS and patient's relief and comfortability levels. Results: 45% of patients of refractory CRS had LPR with the posterior larynx being mainly involved. The major signs and symptoms of CRS were nasal obstruction, nasal discharge, and nasal polyps. There was more improvement in nasal obstruction, nasal discharge, and post-nasal discharge in patients of study group with PPI as compared to control group without PPI. There was better relief of symptoms in patients given PPI as compared to control group and this improvement was more marked at 3 rd post-operative visit after 3 months. Conclusion: There is a strong association between refractory CRS and LPR. PPI are an effective drug for refractory CRS when given as adjuvant therapy along with FESS.

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Section: Discussionsupporting

confidence: 65%

“…[17] Pincus et al also reported 56% improvement of sinonasal symptoms with PPI. [19] DiBiase et al reported the improvement most discreet after 3 months of treatment with PPI [16] which goes along with our study results.…”

Section: Discussionmentioning

confidence: 99%

Correlation between chronic rhinosinusitis and laryngopharyngeal reflux

Nanda¹,

Kaur²,

Gupta³

2017

Natl J Physiol Pharm Pharmacol

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“…However, nasopharyngeal measurements give more accurate results than distally located probe measurements in terms of the presence of reflux. Of the 42 patients undergoing dual pH probe, 10 (23.8%) were found to have pathologic esophageal reflux, indicating a prevalence of GER that was clinically significant and much higher than a 5% prevalence anticipated in the general population [9].…”

Section: Discussionmentioning

confidence: 79%

“…The exposure of the upper aerodigestive tract to gastric secretions results in numerous pathologic conditions such as chronic rhinosinusitis, recurrent otitis media, chronic cough, and airway abnormalities etc. [9,10]. GER has recently been a popular cause of chronic adenotonsillar hypertrophy in the literature [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

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Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Aydın

Aydoğan

Taştan

et al. 2011

Indian J Otolaryngol Head Neck Surg

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To investigate whether there is any association between nasopharyngeal reflux and adenoid hypertrophy in children by using 24-h pH monitoring with dual probe and to determine whether Helicobacter pylori simply colonises in adenoid tissue or it is present there temporarily due to extraesophageal reflux. A prospective study at a tertiary referral center. Thirty-two patients who underwent adenoidectomy, aged ranged between 4 and 13 were included. All children with adenoid hypertrophy underwent 24-h pH monitoring with a dual probe. Proximal probe was placed in the nasopharynx. The presence of nasopharyngeal reflux and gastroesophageal reflux were investigated by 24-h pH monitoring. The presence of H. pylori was investigated in adenoidectomy samples by HP-fast test. Of the 32 patients who underwent adenoidectomy, 5 had nasopharyngeal reflux positivity while 27 patients did not show nasopharyngeal reflux positivity with pH monitorisation. Helicobacter pylori could not be detected in 5 nasopharyngeal reflux positive children while 3 of 27 nasopharyngeal reflux negative children showed H. pylori positivity, one of them in the mucosa and others in the core. This study demonstrated the high incidence of nasopharyngeal reflux and gastroesophageal reflux in adenoid hypertrophy and the possible colonisation of H. pylori in the adenoid tissue. This may change the assesment of children with adenotonsillar hypertrophy in near future. However, more placebo controlled and double blind studies and larger series are still needed to support this hypothesis.

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