Gastroesophageal reflux disease

Fock, Kwong Ming; Poh, Choo Hean

doi:10.1007/s00535-010-0274-9

Cited by 20 publications

(16 citation statements)

References 66 publications

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“…NERD (nonerosive reflux disease) patients account for 60% to 70% of GERD patients [2] and have no signs of esophagitis in endoscopy. Therefore, negative endoscopic results cannot exclude GERD, which decreases the sensitivity of endoscopy [3]. Previously, 24-hour esophageal pH monitoring was used as the “gold standard” for GERD diagnosis.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Significance of Coapplying a Rabeprazole Test with the SF-36 for Gastroesophageal Reflux Disease

Chen

Wang²,

Jiang³

et al. 2013

Gastroenterology Research and Practice

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Gastroesophageal reflux disease is a diversity disease that affects life quality of people in the world. Due to the complicated pathogenesis and variations in clinical manifestations, there is still no true gold standard for GERD diagnosis, and it is still difficult to diagnose this disease in some patients. The proton pump inhibitor's diagnostic test (the PPI test) is noninvasive, of low cost, tied to treatment, and widely accepted. Our aim is to evaluate the diagnostic significance of coapplying a rabeprazole test with the SF-36 for GERD in this study. Our study shows that the SF-36 in combination with the rabeprazole test can screen GERD patients and increase the sensitivity and specificity of GERD diagnosis through reference to the change in SF-36 score before and after the treatment (65 in the trial).

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Section: Introductionmentioning

confidence: 99%

The Diagnostic Significance of Coapplying a Rabeprazole Test with the SF-36 for Gastroesophageal Reflux Disease

Chen

Wang²,

Jiang³

et al. 2013

Gastroenterology Research and Practice

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“…16 Using a PPI when required will be adequate for some patients, however 75-90% will relapse over six months. 5 This reflects the chronic nature of the condition rather than a failure of treatment. Surveillance gastroscopy is not required in patients with GORD.…”

Section: Maintenance Therapymentioning

confidence: 99%

The management of gastro-oesophageal reflux disease

Keung¹,

Hebbard²

2016

Aust Prescr

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“…Reflux esophagitis is a common disease not only in Western countries but also in Oriental countries, including Japan [1,2,3,4]. The prevalence of reflux esophagitis, especially severe esophagitis of grades C and D, is high in aged Japanese women [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

et al. 2012

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Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance.

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Gastroesophageal reflux disease

Cited by 20 publications

References 66 publications

The Diagnostic Significance of Coapplying a Rabeprazole Test with the SF-36 for Gastroesophageal Reflux Disease

The Diagnostic Significance of Coapplying a Rabeprazole Test with the SF-36 for Gastroesophageal Reflux Disease

The management of gastro-oesophageal reflux disease

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

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