Gastroesophageal reflux disease and diabetes mellitus: pathophysiological mechanisms of comorbidity

Кузнецова, Е. И.; Dentistry, Moscow; Rymareva, Ekaterina A.; Дичева, Д. Т.; Андреев, Д. Н.

doi:10.26442/20751753.2019.8.190497

Cited by 3 publications

(3 citation statements)

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“…ст. [31], что приводит к более выраженной дисфагии у пациентов с ожирением [23,32]. При выполнении манометрии пищевода было выявлено, что у людей с ожирением более высокие показатели желудочного давления и среднего градиента гастроэзофагеального давления, что способствует прогрессированию ГЭРБ и развитию гиперконтрактильного пищевода [33].…”

Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

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Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.

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Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

View full text Add to dashboard Cite

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“…Имеются данные о его более высоких уровнях в плазме крови натощак при СБЭ по сравнению с ПДС [27]. Также показана возможность усиления моторной функции желудка введением мотилина и его агонистов с терапевтической целью [28].…”

Section: резюмеunclassified

“…Концентрация мотилина в крови натощак у пациентов с постпрандиальным дистресс-синдромом оказалась статистически значимо выше, чем у обследованных с синдромом боли в эпигастрии, находясь при этом в диапазоне нормальных величин. Более высокий его уровень при ПДС не противоречит, характерным для него нарушениям желудочной моторики и совпадает с данными, полученными другими авторами при гастропарезе [28].…”

Section: результаты и обсуждениеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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Purpose of the study: to clarify the effect of the concentration of motilin in the blood on the clinical symptoms of functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22,3±0,17 years was carried out, divided into 3 groups: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. All subjects were questioned according to the GSRS questionnaire, and the concentration of motilin in their blood was determined before and after the drinking test. Statistical processing included the calculation of mean values, their errors, Student’s t-test, Pearson’s correlation test, factor analysis. Results. In patients with PDS, the intensity of abdominal pain (2,47±0,38 points) does not differ from healthy ones (2,19±0,22 points), in patients with EPS it is higher (4,33±0,51 points). Dyspeptic syndrome is more typical for patients with PDS (2,07±0,12 points) than for EPS (1,10±0,04 points). The concentration of motilin in the blood on an empty stomach with PDS (9605,47±167,64 pg/ml) is higher than with EPS (8780,67±232,27 pg/ml). After the drinking test, the level of motilin in the blood of patients with EPS increased to 9367,33±145,78 pg/ml, the PDS decreased to 9323,33±239,04 pg/ml. With PDS, the severity of reflux syndrome directly correlates with the concentration of motilin in the blood. In EPS, the initial level of motilin correlates inversely with the severity of reflux syndrome, constipation syndrome, and the volume of water drunk. After the drinking test, there is an inverse correlation between the level of motilin and the severity of diarrheal and dyspeptic syndromes, and a direct correlation with the intensity of abdominal pain. The initial level of motilin in the blood brings the greatest factor load into the “factor of motor disorders”. Conclusion. The initial level of motilin and its dynamics during water load play an essential role in the formation of the clinical picture of functional dyspepsia.

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Balneotherapy of epigastric pain syndrome: the meaning of motilin in the implementation of the therapeutic effect

Shklyaev

Казарин

Григорьева

2023

Med. vestn. Ûga Ross.

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Objective: to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods: 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results: in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion: patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.

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Gastroesophageal reflux disease and diabetes mellitus: pathophysiological mechanisms of comorbidity

Cited by 3 publications

References 0 publications

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Balneotherapy of epigastric pain syndrome: the meaning of motilin in the implementation of the therapeutic effect

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