Gastroesophageal Reflux Disease and Obesity

Abstract

The global rise of gastroesophageal reflux disease (GERD) prevalence makes it one of the most common diagnoses performed in a daily practice. Obesity significantly contribute to GERD development, accordingly, it has accounted for the increasing cases of GERD. Obesity can disrupt the esophagogastric junction integrity, which promote the development of GERD and its complication. The frequency of GERD symptoms and its mucosal complications also found more often in obesity. The parallel increase of both condition has initiated numerous studies to determine the most beneficial therapeutic options in managing this challenging condition. Current available therapy for GERD in obesity including weight reduction, pharmacotherapy, and surgery.

Gambaran Klinis Hasil Pemeriksaan Esofagogastroduodenoskopi pada Pasien Dispepsia di RSUD Prof. Dr. W. Z. Johannes Kupang Tahun 2020-2021

“…GERD dapat menyebabkan komplikasi berupa barrett's esofagus yaitu kondisi dimana terdapat sel metaplasia pada esofagus karena paparan asam terus menerus. 20,21 Tumor saluran cerna bagian atas lebih banyak pada perempuan, terutama pada tumor yang dicurigai keganasan, namun pada kelompok usia tidak terdapat perbedaan yang signifikan pada usia muda maupun tua. Gambaran hasil PA membuktikan adanya keganasan dengan ditemukan gambaran adenokarcinoma (48%), squamous cell carcinoma (SCC) sebanyak 32%, 1 pasien menderita non-hodgkin lymphoma, dan 1 pasien menderita neuroendokrin karsinoma serta 3 pasien (12%) yang tidak ditemukan tanda metaplasia maupun displasia.…”