Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Uncertainties and Controversies

Wang, Zheng; Bonella, Francesco; Li, Wenting; Boerner, E.; Guo, Qingge; Kong, Xianglong; Costabel, Ulrich; Kreuter, Michael

doi:10.1159/000492336

Cited by 24 publications

(33 citation statements)

References 74 publications

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“…In addition, dysphagia is a rare manifestation in both AAV 52 and sarcoidosis 53 . Whereas, it is suggested that gastroesophageal reflux disease (GERD)-associated microaspiration may lead to the progression of idiopathic pulmonary fibrosis (IPF) and IPF may increase intrathoracic pressure, which can aggravate GERD vice versa 54 . GERD is a common problem in sarcoidosis 55 , but not in AAV 56 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

Fukui

Morimoto

Ichinose

et al. 2020

Sci Rep

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Microbial involvement in the pathogenesis have been suggested in both antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and sarcoidosis, both of which have lung involvement. However, exhaustive research to assess the bacteria in the lung in AAV and in sarcoidosis have not been performed. We sought to elucidate the distinct dysbiotic lung microbiota between AAV and sarcoidosis. We used 16S rRNA gene high-throughput sequencing to obtain the bacterial community composition of bronchoalveolar lavage fluid (BALF) in patients with AAV (n = 16) compared to patients with sarcoidosis (n = 21). The patients had not undergone therapy with immunosuppressive medication when their BALF was acquired. No difference was observed in α-diversity between patients with AAV and patients with sarcoidosis when using all the detected taxa. We defined the taxa of the oral cavity by using the data of oral microbiota of healthy individuals from the Human Microbiome Project (HMP). The analysis using only oral taxa made the difference in α-diversity between AAV and sarcoidosis clearer compared with those using all the detected taxa. Besides, the analysis using detected taxa except for oral taxa also made the difference in α-diversity between AAV and sarcoidosis clearer compared with those using all the detected taxa. A linear negative relationship between the α-diversity and Birmingham vasculitis activity score (BVAS) was detected in the AAV group. The observed p-value for the effect of the disease groups on the ß-diversity was small while the effect of other factors including sex and smoking status did not have small p-values. By excluding oral taxa from all the detected taxa, we found a cluster mainly consisted of sarcoidosis patients which was characterized with microbial community monopolized by Erythrobacteraceae family. Our results suggested the importance of considering the influence of oral microbiota in evaluating lung microbiota. Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are forms of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a systemic disease affecting multiple organs including the lungs and kidneys. The production of ANCA, playing a pathogenetic role in AAV, is thought to be initiated by exogenous or endogenous antigens including microbes, drugs, or dysregulated autoantigen expression 1. Patients

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Section: Discussionmentioning

confidence: 99%

Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

Fukui

Morimoto

Ichinose

et al. 2020

Sci Rep

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“…In a longitudinal study of 105 SSc patients, our group did not find that esophageal involvement measured by manometry was a prognostic factor for ILD progression . Consistently in IPF, the link between GERD and ILD remains controversial . Deciphering the relationships between GERD and ILD remains critical in SSc, but also in ILDs overall, and further investigation to clarify this issue is warranted.…”

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confidence: 66%

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Elhaï

Hoffmann-Vold

Allanore

2019

Arthritis & Rheumatology

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“…Breathing appears as the more frequent problem followed by sleep disorders. In the literature breathing was associated with gastroesophageal reflux [23], high fat disease [24] and obesity [25].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Disorders: Physiology and Patient Problems

Santos-Filho¹

2018

Anat Physiol

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Respiratory disorders are worldwide studied. The aim of this study was to verify in scientific publications founded in PubMed database the disorders more common that affected the respiratory system and to evaluate the problems concerning to the patients. The methodology was using the words "respiratory disorders", patient, problems, in the PubMed to find the publications that treat these words. We founded 3620 publications of "respiratory disorders", 1422 were associated with patient, 94 publications were associated with the last research with problems. It was founded that out of 38 publications in last ten years 28 were associated with humans. The prevalence of respiratory disorders, like breathing and asthma problems, due to the difficulties faced by patients, were co-related with obesity and smoke mainly.

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Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Uncertainties and Controversies

Cited by 24 publications

References 74 publications

Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

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Respiratory Disorders: Physiology and Patient Problems

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