Gastroesophageal Reflux Disease in Infants and Children

Khan, Seema; Orenstein, Susan R.

doi:10.1007/3-211-32317-1_4

Cited by 6 publications

(10 citation statements)

References 130 publications

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“…Acid reflux events are more likely to result in clinical manifestations when they are frequent, inefficiently cleared, and more acidic (6,7). In symptomatic infants, classic 2-phase and pH-only acid reflux events have been shown to make up the majority of total acid reflux episodes, the majority of total acid gastroesophageal reflux exposure time, and the majority of acid reflux episodes lasting 5 minutes or longer (5).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenicity of acid reflux (ie, the ability to cause esophageal damage and/or produce symptoms) is a function of interactions among variables that are likely to include the frequency, duration, and pH of individual acid reflux events. Acid reflux events are more likely to result in clinical manifestations when they are frequent, inefficiently cleared, and more acidic (6,7). In symptomatic infants, classic 2-phase and pH-only acid reflux events have been shown to make up the majority of total acid reflux episodes, the majority of total acid gastroesophageal reflux exposure time, and the majority of acid reflux episodes lasting 5 minutes or longer (5).…”

Section: Discussionmentioning

confidence: 99%

“…Considering the impact of classic 2‐phase episodes and POEs on gastroesophageal acid exposure in infants, the purpose of this investigation was to compare these 2 acid reflux types on the basis of variables that are known to influence the pathogenicity of acid reflux (ie, frequency, duration, and pH) (6,7). Because feeding has been shown to influence duration of the chemical clearance of classic 2‐phase episodes in infants (4), we assessed classic 2‐phase and pH only acid reflux events on the basis of these 3 characteristics, during each of 4 periods related to feeding: feeding, the first postprandial hour (1stPP), the second postprandial hour (2ndPP), and fasting (4).…”

mentioning

confidence: 99%

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“pH‐Only” Acid Reflux Events in Infants During Later Phases of the Feeding Cycle Are Less Acidic and Cleared More Efficiently Than Classic 2‐Phase Acid Reflux Events

Woodley

Mousa²

2009

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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“pH‐Only” Acid Reflux Events in Infants During Later Phases of the Feeding Cycle Are Less Acidic and Cleared More Efficiently Than Classic 2‐Phase Acid Reflux Events

Woodley

Mousa²

2009

J. pediatr. gastroenterol. nutr.

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“…Children with chronic respiratory and neurologic diseases commonly experience recurrent or chronic GERD symptoms. Half of the older children with GERD have chronic relapsing disease [3]. The first line of treatment for combined reflux gastroesophagitis with hiatus hernia is conservative therapy with an emphasis on thickened meals, smaller meal volume, proper positioning, and medicines.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Reflux Gastroesophagitis in a Patient with Spinal Muscular Atrophy after Surgical Correction of Kyphoscoliosis: A Case Report

Yang

Kasat

Suh

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Scoliosis, a three-dimensional deformity, has secondary effects on the gastrointestinal system. Reflux gastroesophagitis with hiatus hernia in patients with scoliosis is difficult to manage. We present a patient in whom primary correction of a spinal deformity was associated with resolution of symptoms of reflux. Case Description A 15-year-old girl with severe thoracolumbar kyphoscoliosis visited our scoliosis research institute complaining of back pain, positional imbalance, intermittent respiratory tract infections, and gastrointestinal discomfort such as pain, dysphagia, and heartburn for several years. On preoperative CT, her abdominal organs were in a deviant position, and esophagogastroduodenoscopy revealed severe reflux gastroesophagitis, Los Angeles classification (LA) Grade D, and a sliding hiatus hernia. After kyphoscoliosis correction, the patient's truncal balance and pain improved. Postoperatively, the patient reported abdominal pain and dysphagia that gradually subsided after 3 weeks. At 1 year, the patient had no abdominal complaints secondary to reflux gastroesophagitis, and episodes of recurrent respiratory tract infections were substantially reduced. Postoperative evaluation showed the reflux gastroesophagitis had improved to LA Grade A. Postoperative CT showed the abdominal cavity had expanded and the abdominal organs were more centered. Literature Review The association between scoliosis and reflux gastroesophagitis is well documented. However, the secondary effects of scoliosis correction on gastrointestinal symptoms caused by reflux gastroesophagitis have not been investigated in detail. Purpose and Clinical Relevance This patient illustrates the relationship between spinal deformity and gastrointestinal symptoms. Postural balance correction resulted in the alleviation of reflux gastroesophagitis symptoms secondary to hiatus hernia.

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“…amžiaus GER nustatomas 60-70 proc. kūdikių, iki 1 m. amžiaus jis išnyksta [1,6]. GERL paplitimas skiriasi priklausomai nuo regiono: Šiaurės Amerikoje, Europoje ir Artimuosiuose Rytuose jis yra didesnis (10-30 proc.)…”

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Gastroezofaginio Refliukso Rizikos Veiksnių Pasiskirstymas Tarp Skirtingo Amžiaus Grupių

Stirbytė,

Vindžigalskytė,

Žukovienė

2024

Health Sciences

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Tikslas. Atlikti literatūros šaltinių analizę apie gastroezofaginio refliukso rizikos veiksnių pasiskirstymą tarp skirtingo amžiaus grupių. Metodai. Remiantis PubMed ir ClinicalKey duomenų bazių šaltiniais, atrinkta ir išanalizuota 21 publikacija. Išvados. Pagrindiniai kūdikių ir vaikų GERL rizikos veiksniai yra hiatalinė išvarža, neurologiniai vystymosi sutrikimai, cistinė fibrozė, epilepsija, įgimtos stemplės anomalijos, astma ir neišnešiotumas, o paaugliams ir suaugusiesiems − vaikystėje buvusi GERL, blogi mitybos įpročiai, antsvoris ar nutukimas, rūkymas, alkoholio vartojimas, tam tikrų vaistų vartojimas, psichologinis stresas, prasta miego kokybė.

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Gastroesophageal Reflux Disease in Infants and Children

Cited by 6 publications

References 130 publications

“pH‐Only” Acid Reflux Events in Infants During Later Phases of the Feeding Cycle Are Less Acidic and Cleared More Efficiently Than Classic 2‐Phase Acid Reflux Events

“pH‐Only” Acid Reflux Events in Infants During Later Phases of the Feeding Cycle Are Less Acidic and Cleared More Efficiently Than Classic 2‐Phase Acid Reflux Events

Improvement in Reflux Gastroesophagitis in a Patient with Spinal Muscular Atrophy after Surgical Correction of Kyphoscoliosis: A Case Report

Gastroezofaginio Refliukso Rizikos Veiksnių Pasiskirstymas Tarp Skirtingo Amžiaus Grupių

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