Gastroesophageal Reflux Disease in Obesity: Bariatric Surgery as Both the Cause and the Cure in the Morbidly Obese Population

Masood, Muaaz; Low, Donald; Deal, Shanley B.; Kozarek, Richard A.

doi:10.3390/jcm12175543

Cited by 9 publications

(3 citation statements)

References 151 publications

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“…A comprehensive, stepwise approach to the management and treatment of GERD following SG has recently been published by Masood et al [ 45 ]. Lifestyle modifications are initially recommended following SG as part of a comprehensive bariatric surgery center’s pre- and postoperative education and long-term follow-up plan with patients.…”

Section: Discussionmentioning

confidence: 99%

Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease following Sleeve Gastrectomy

Masood,

Low,

Deal

et al. 2024

JCM

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Obesity is associated with serious comorbidities and economic implications. Bariatric surgery, most commonly Roux-en-Y gastric bypass and sleeve gastrectomy, are effective options for weight loss and the improvement of obesity-related comorbidities. With the growing obesity epidemic, there has been a concomitant rise in bariatric surgeries, particularly in sleeve gastrectomy, which has been the most widely performed bariatric surgery since 2013. Gastroesophageal reflux disease (GERD) is highly prevalent in obese individuals, can significantly impact quality of life and may lead to serious complications. Obesity and GERD both improve with weight loss. However, as the incidence of sleeve gastrectomy rises, recent data have revealed a risk of exacerbation of pre-existing GERD or the development of de novo GERD following sleeve gastrectomy. We performed a detailed review of GERD post-sleeve gastrectomy, including its overall incidence, pathophysiology and current treatment paradigms.

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Section: Discussionmentioning

confidence: 99%

Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease following Sleeve Gastrectomy

Masood,

Low,

Deal

et al. 2024

JCM

Self Cite

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“…Among them, GERD has great importance as it strongly affects quality of life (12,36) and incurs costs related to long-term use of medications, with potential sideeffects (37) and the need for additional revisional surgeries (38). Recent reports have demonstrated that among gastric bypasses, OAGB may be associated not only with biliary reflux but also with acid reflux (39), and RYGB, even if it is the gold standard procedure to treat associated obesity and GERD, is associated with a non-negligible rate of long-term reflux (12,16,(40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

PETRUCCIANI,

BENOIS,

AURELLO

et al. 2024

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Background/Aim: Long-term gastroesophageal reflux (GERD) after gastric bypass for obesity is underestimated. The present study aimed to evaluate the rate of treated GERD and the factors influencing it in a cohort of patients who underwent gastric bypass. Patients and Methods: Patients who underwent one-anastomosis gastric bypass (OAGB) or Roux-en-Y gastric bypass (RYGB) as a primary bariatric procedure between 2010 and 2011 at a French private referral center were included in the study. The primary endpoint was the 10-year prevalence of GERD. Results: In total, 422 patients underwent RYGB and 334 underwent OAGB with a biliopancreatic limb of 150 cm. The mean age was 38.9±11.3 years, and 81.6% of patients were female; the mean preoperative body mass index was 42.8±5 kg/m 2 . Preoperative GERD was diagnosed in 40.8% of patients in the total cohort, 31.7% in the RYGB group versus 49.1% in the OAGB group (p<0.0001). At 10-year followup, the rate of GERD was 21.1%, with no difference between the two groups. Remission of preoperative GERD and de novo GERD were comparable between the two types of bypass. Surgery for GERD resistant to medical treatment was more frequent in the OAGB group. At multivariate analysis, factors significantly correlated with long-term GERD were: Preoperative GERD, total weight loss at 120 months <25%, glycemic imbalances and anastomotic ulcers. Conclusion: Identification and correction of modifiable factors may help reduce the incidence of long-term GERD.

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“…GERD typically manifests as heartburn and regurgitation, although atypical symptoms (i.e., cough, laryngitis, asthma, or chest pain) may be present in some patients. Masood et al details the current management and treatment paradigms of post-SG GERD in a recently published review [124]. Endoscopy may be performed as part of a diagnostic work-up, which can also include esophagram, esophageal manometry, and pH testing, for further anatomical and physiological eval-uation in selected patients presenting with GERD.…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Endoscopic Management of Post-Sleeve Gastrectomy Complications

Masood,

Low,

Deal

et al. 2024

JCM

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Obesity is associated with several chronic conditions including diabetes, cardiovascular disease, and metabolic dysfunction-associated steatotic liver disease and malignancy. Bariatric surgery, most commonly Roux-en-Y gastric bypass and sleeve gastrectomy, is an effective treatment modality for obesity and can improve associated comorbidities. Over the last 20 years, there has been an increase in the rate of bariatric surgeries associated with the growing obesity epidemic. Sleeve gastrectomy is the most widely performed bariatric surgery currently, and while it serves as a durable option for some patients, it is important to note that several complications, including sleeve leak, stenosis, chronic fistula, gastrointestinal hemorrhage, and gastroesophageal reflux disease, may occur. Endoscopic methods to manage post-sleeve gastrectomy complications are often considered due to the risks associated with a reoperation, and endoscopy plays a significant role in the diagnosis and management of post-sleeve gastrectomy complications. We perform a detailed review of the current endoscopic management of post-sleeve gastrectomy complications.

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Gastroesophageal Reflux Disease in Obesity: Bariatric Surgery as Both the Cause and the Cure in the Morbidly Obese Population

Cited by 9 publications

References 151 publications

Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease following Sleeve Gastrectomy

Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease following Sleeve Gastrectomy

Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

Endoscopic Management of Post-Sleeve Gastrectomy Complications

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