Gastroesophageal Reflux Disease in Time Covering Eradication for All Patients Infected with &lt;b&gt;&lt;i&gt;Helicobacter pylori&lt;/i&gt;&lt;/b&gt; in Japan

Sugimoto, Mitsushige; Uotani, Takahiro; Ichikawa, Hitomi; Andoh, Akira; Furuta, Takahisa

doi:10.1159/000441741

Cited by 30 publications

(29 citation statements)

References 26 publications

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“…Furthermore, the Japanese evidence-based clinical practice guideline for FD strongly recommends the use of H. pylori eradication therapy due to a high evidence level [4]. However, the relationship between H. pylori eradication therapy and the development of gastroesophageal reflux disease (GERD) remains controversial [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

et al. 2018

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Background/Aims: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. Methods: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital. Results: H. pylori eradication therapy for chronic atrophic gastritis improved latent digestive symptoms, including both the acid reflux and dyspepsia components in the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) scores. The effect was sustained until 1 year after the treatment. Higher FSSG scores (≥8 points) before H. pylori eradication therapy and age <70 years were significantly associated with the improvement of digestive symptoms after H. pylori eradication therapy. Conclusion: H. pylori eradication therapy may improve patients’ quality of life through the resolution of latent abdominal symptoms.

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Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

et al. 2018

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“…Although previous studies indicated that reflux esophagitis was developed following eradication therapy [4, 15], recent studies in Japan have indicated that the frequency or severity of this esophagitis, evaluated by endoscopy, was not serious [16–20]. Evaluation of reflux symptoms after eradication can be difficult, and one study in Japan suggested that the reflux symptoms might be improved and/or not exacerbated after eradication [21].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection status had no influence on upper gastrointestinal symptoms: a cross-sectional analysis of 3,005 Japanese subjects without upper gastrointestinal lesions undergoing medical health checkups

et al. 2017

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BackgroundThis study aimed to evaluate the influence of Helicobacter pylori infection and its eradication on the upper gastrointestinal symptoms of relatively healthy Japanese subjects.MethodsA total of 3,005 subjects (male/female: 1,549/1,456) undergoing medical health checkups were enrolled in the present study, at five hospitals in Saga, Japan, from January to December 2013. They had no significant findings following upper gastrointestinal endoscopy. All subjects completed a questionnaire that addressed a frequency scale for symptoms of gastroesophageal reflux disease. The questionnaire comprised seven questions regarding reflux symptoms and seven regarding acid-related dyspepsia, which were answered with a score based on the frequency of symptoms. Helicobacter pylori infection was identified by a rapid urease test and/or H. pylori antibody titer, and an eradication history was confirmed by the subjects’ medical records.Results Helicobacter pylori infection was positive in 894 subjects out of 3,005 (29.8%). Eradication of Helicobacter pylori was successfully achieved in 440 subjects of 458 treated. Helicobacter pylori infection had no influence on the acid-related dyspepsia evaluated by the questionnaire, whereas the mean reflux score was relatively high in the Helicobacter pylori native negative subjects compared to Helicobacter pylori native positive. Eradication of Helicobacter pylori and time span after the eradication had no effect on the upper gastrointestinal symptoms evaluated by the questionnaire.Conclusion Helicobacter pylori infection and history of eradication did not affect acid-related dyspepsia symptoms in Japanese healthy subjects.

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“…In recent years, the hygienic environment in Japan has markedly improved [12]. Although the incidence of H. pylori infection in individuals 50 years old or older exceeds 50%, the incidence of H. pylori infection in younger individuals is progressively lower with increasing age.…”

Section: Reasons For the Increase In The Incidence Of Barrett's Esophmentioning

confidence: 99%

The Present Status and Future of Barrett’s Esophageal Adenocarcinoma in Japan

et al. 2018

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Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States. Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6.5–7.1%. Causes include the increase in the incidence of obesity due to changes in eating habits with resultant increases in the incidence of hiatal hernia and reflux esophagitis, a decrease in the rate of Helicobacter pylori infection, and the increased interest of physicians in the gastroesophageal junction. The number of gastroesophageal reflux disease patients in Japan rapidly increased from the 1990s, which accordingly increased the number of Barrett’s esophageal adenocarcinoma patients from the latter half of the 1990s. Tabulation and analysis of 1,794 reported cases of Barrett’s esophageal adenocarcinoma in Japan showed that superficial cancers accounted for 77.6%, and that the concomitant rates of hiatal hernia and reflux esophagitis were high at 87 and 70% respectively. Key Message: The future trend in the incidence of Barrett’s esophageal adenocarcinoma in Japan will depend on the increase in the incidence of reflux esophagitis, which is essential for the development of Barrett’s esophagus and Barrett’s esophageal carcinoma. The obesity rate is lower in Japan than that in Europe and the United States, and the incidence and severity of reflux esophagitis are low. We expect that the incidence of Barrett’s esophageal adenocarcinoma in Japan will not rise as high as in Europe and the United States, and will remain below 10%.

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Gastroesophageal Reflux Disease in Time Covering Eradication for All Patients Infected with <b><i>Helicobacter pylori</i></b> in Japan

Cited by 30 publications

References 26 publications

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

Helicobacter pylori infection status had no influence on upper gastrointestinal symptoms: a cross-sectional analysis of 3,005 Japanese subjects without upper gastrointestinal lesions undergoing medical health checkups

The Present Status and Future of Barrett’s Esophageal Adenocarcinoma in Japan

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