Gastroesophageal reflux disease is associated with enteric hormone abnormalities

Perdikis, Galen; Wilson, Paul; Hinder, Ronald A.; Redmond, Elizabeth; Wetscher, Gerold J.; Saeki, Shuji; Adrian, Thomas E.

doi:10.1016/0002-9610(94)90072-8

Cited by 39 publications

(22 citation statements)

References 29 publications

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“…One possible clinical relevance of this mechanism was investigated by Perdikis et al [27]. These authors demonstrated a significant increase in fasting plasma concentrations of NT, but only in patients with gastroesophageal reflux disease associated with a decreased LESP.…”

Section: Discussionmentioning

confidence: 97%

Neurotensin-related regulation of the postprandial lower-oesophageal-sphincter pressure

Horstmann¹,

Nustede²,

Neufang³

et al. 1999

Langenbeck's Archives of Surgery

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Section: Discussionmentioning

confidence: 97%

Neurotensin-related regulation of the postprandial lower-oesophageal-sphincter pressure

Horstmann¹,

Nustede²,

Neufang³

et al. 1999

Langenbeck's Archives of Surgery

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“…The phrenoesophageal ligament is a part of the subperitoneal fascia. It originates from the diaphragm decreased in GERD patients, whereas neurotensin is increased [47]. and keeps the intra-abdominal LES in close proximity to the hiatal crura.…”

Section: Pathophysiology Of Gerdmentioning

confidence: 99%

Selection of Patients for Laparoscopic Antireflux Surgery

Glaser¹,

Wetscher²,

Klingler³

et al. 2000

Dig Dis

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Since the first laparoscopic fundoplication was performed, the frequency of antireflux surgery has increased rapidly with some centers now having an experience of about 1,000 procedures. The question arises whether this increase is due to a change in indications for the surgical treatment of gastrointestinal reflux disease (GERD) despite the simultaneous appearance of powerful antisecretory medications. Adequate knowledge of the pathophysiology of GERD is necessary in order to establish selection criteria for patients suitable for laparoscopic antireflux surgery. In this article, we review the epidemiology and pathophysiology, and provide a rationale for medical and surgical treatment. We also offer an approach to patient selection for antireflux surgery.

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“…The hormone is found in enterochromaffin cells in the duodenum and jejunum, and ingestion of fat and gastric acid stimulates secretion of motilin into the bloodstream [9,10]. Patients with reflux have been shown to have altered motilin levels [11]. …”

Section: Introductionmentioning

confidence: 99%

Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life: a prospective case–control study

Pendleton

Ahlner-Elmqvist

Olsson

et al. 2013

BMC Ear Nose Throat Disord

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BackgroundLaryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL). Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal symptoms, to analyse motilin levels in plasma, and to assess health-related quality of life (HRQOL) before and after treatment.MethodsForty-six patients (26 women), with verified PL, median age 55 (IQR 41–68) years, were referred to oesophago-gastro-duodenoscopy and 24-h pH monitoring. Plasma motilin was analysed. The 36-item Short-Form questionnaire was completed at inclusion and at follow-up after 43±14 months, when also the Visual Analogue Scale for Irritable Bowel Syndrome was completed. Values were compared to controls. Treatment and relief of symptoms were noted from medical records.ResultsThirty-four percent had proximal acid reflux and 40% showed signs of distal reflux. Ninety-four percent received acid-reducing treatment, with total relief of symptoms in 17%. Patients with reflux symptoms had lower plasma motilin levels compared to patients without reflux symptoms (p = 0.021). The HRQOL was impaired at inclusion, but improved over time. Patients, especially men, had more functional gastrointestinal symptoms than controls.ConclusionsThis study indicates that a minority of patients with PL has LPR and is cured by acid-reducing therapy. Disturbed plasma motilin levels and presence of functional gastrointestinal symptoms are found in PL. The impaired HRQOL improves over time.

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Gastroesophageal reflux disease is associated with enteric hormone abnormalities

Cited by 39 publications

References 29 publications

Neurotensin-related regulation of the postprandial lower-oesophageal-sphincter pressure

Neurotensin-related regulation of the postprandial lower-oesophageal-sphincter pressure

Selection of Patients for Laparoscopic Antireflux Surgery

Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life: a prospective case–control study

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