Gastroesophageal Reflux Disease: Treating Wisely

Wilson, Jeffrey J.; Pruett, Kellner

doi:10.18043/ncm.77.3.202

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…However, with increasing reports about the safety of PPIs, persistent or increased dosing of PPIs without an anticipated successful endpoint has been concerning. [39][40][41] A low success rate of controlling regurgitation with increased doses of PPIs should not be surprising because PPIs merely change the composition of the refluxate and would not be expected to significantly reduce the number of reflux episodes or consistently reduce the volume of reflux.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial

Bell¹,

Lipham

Louie

et al. 2019

Gastrointestinal Endoscopy

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Section: Discussionmentioning

confidence: 99%

Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial

Bell¹,

Lipham

Louie

et al. 2019

Gastrointestinal Endoscopy

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“…It is important to look for specific symptoms since GERD is reported to be usually over diagnosed and over treated. 27 Although, IBS and GERD affect different regions of the intestines, significant overlap in these two conditions has been well documented. 28 Other comorbid conditions like arthritis, diabetes mellitus, coronary artery disease, depression, hypertension and asthma were also commonly observed in patients of APD.…”

Section: Discussionmentioning

confidence: 99%

Clinical profiling of patients with Acid Peptic Disorders (APD) in India: a cross-sectional survey of clinicians

Roop¹,

Gangadhar

Mayabhate

2016

Int J Basic Clin Pharmacol

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Background: Acid peptic disorders (APD) which include GERD and peptic ulcer disease (PUD) are common conditions reported in daily clinical practice. This survey aimed to understand the epidemiology, clinical presentation and associated overlapping comorbidities in Indian patients with APD.Methods: This was an interview based cross-sectional survey of 1000 clinicians (specialist gastroenterologists and non-specialists) across India who treated patients of APD in their practice. Information related to patient demographics, diagnosis and clinical presentation (common symptoms and their duration, alarming, lower GI and extra-esophageal symptoms) were assessed. Indications for upper GI endoscopy, esophageal pH monitoring and esophageal manometry were also collected. Descriptive analyses were done.Results: About 39.2% and 37.1% patients had reported GERD and PUD respectively (duodenal ulcer: 10.5%, gastric ulcer: 9.9% and peptic ulcer-non-specified: 16.7%); 25.2% patients were reported to have non-ulcer dyspepsia. Heartburn was the most common symptom in GERD (60.5%); epigastric pain was common in PUD (72.3%); 49% GERD patients presented with alarming symptoms, mainly dysphagia (67%), whereas for PUD, GI bleeding was the most common alarming symptom (47.6%). Profiles of patients visiting clinicians were similar with respect to the presenting symptoms and associated conditions. Functional dyspepsia (25.9%), constipation (23.4%) and irritable bowel syndrome (23.4%) were the most common overlapping conditions associated with both GERD and PUD.Conclusions: APD (GERD and PUD) was more common in 18-59 yrs. age group with heart burn as the common symptom for GERD and epigastric pain for PUD. Diagnosis was mostly based on clinical symptoms; nearly 50% patients of APD presenting with alarming symptoms needed prompt endoscopy. Thus, there is need to focus on these overlapping disorders while managing patients of APD.

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“…This phenomenon should raise special attention because prolonged regurgitation may lead to GERD [6]. Prevalence of GERD itself is increasing by 8.5% in East Asia and 10-20% in Western Europe and North America [8].…”

Section: Introductionmentioning

confidence: 99%

Exclusive Breastfeeding Lowers Incidence of Gastroesophageal Reflux in Infants: a 12-month Cohort Study

Mairuhu¹,

Darma²,

Ranuh³

2021

IJRP

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Introduction: Gastroesophageal reflux (GER) is the involuntary passage of stomach contents to the esophagus with or without regurgitation and vomiting. Studies conducted in Indonesia showed that episodes of regurgitation persisted longer and its incidence was 2 times higher than other ethnics even in 12 months old. In fact, prolonged regurgitation may lead to gastroesophageal reflux disease. This study aims to evaluate exclusive breastfeeding as protective factor toward incidence of GER in infants aged 0-1 month old.Materials and method: This study was a prospective cohort study involving all infants aged 0-1 month old in several hospitals at Surabaya, Sidoarjo, and Gresik. Subjects were classified into 2 groups: exclusively breastfed groups and non-exclusively breastfed groups. Diagnosis of GER was made from history taking and physical examination, according to Rome IV criteria. Follow-ups were conducted at 3, 6, and 12 months in order to know if subjects showed any symptoms of GER or not.Results: A total of 222 subjects followed this study until 12 months. Result showed that fewer infants under exclusively breastfed group showed symptoms of GER after 6 months duration or more. Incidence of GER in both exclusively breastfed group and nonexclusively breastfed group did not differ significantly at 3 months. Conclusion:Exclusive breastfeeding exhibited protective effect toward GER in infants aged 0-1 year. Meanwhile, non-exclusively breastfed infants either bottle-fed with breastmilk, formula-fed, or any combination between breastfed and formula-fed, increased risk for GER by 1.45 times. Therefore, it is highly recommended to give exclusive breastfeeding for infants.

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Gastroesophageal Reflux Disease: Treating Wisely

Cited by 6 publications

References 14 publications

Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial

Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial

Clinical profiling of patients with Acid Peptic Disorders (APD) in India: a cross-sectional survey of clinicians

Exclusive Breastfeeding Lowers Incidence of Gastroesophageal Reflux in Infants: a 12-month Cohort Study

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