Gastroesophageal reflux occurring after repair of congenital diaphragmatic hernia

Nagaya, Masahiro; Akatsuka, Hiroshi; Kato, Junji

doi:10.1016/0022-3468(94)90141-4

Cited by 69 publications

(39 citation statements)

References 15 publications

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“…Seven children (23%) had a weight below the 5th percentile, which is within the range of 20-40% reported by Jaillard et al [13]. Persistent gastrointestinal, respiratory symptoms or food aversion may contribute to growth failure in CDH survivors [12,13,20,29]. Two of seven children (29%) with FTT were having chronic respiratory problems but there was no obvious cause in four children.…”

Section: Discussionmentioning

confidence: 57%

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The immediate and long-term outcomes of newborns with congenital diaphragmatic hernia

et al. 2006

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In spite of the innovations in the management of newborns with congenital diaphragmatic hernia (CDH) presenting with respiratory distress at birth, mortality and ongoing morbidity still remain high. This is a retrospective analysis of newborns with CDH to determine the immediate and long-term outcomes among survivors. Medical records of newborns with CDH and respiratory distress at birth between January 1993 and March 2002 were reviewed retrospectively. There were 45 newborns, 29 males and 16 females. Eleven newborns (24%) died during the period of preoperative stabilization, 9 from pulmonary hypoplasia and 2 with complex anomalies who were not resuscitated. Surgery was performed in 34 newborns (76%). Three died postoperatively from severe pulmonary hypoplasia and pulmonary hypertension. Eleven newborns (24%) had sepsis from coagulative-negative staphylococci. Thirty-one of 43 newborns (72%) with isolated CDH were discharged home. Twenty-seven of 31 survivors (87%) had adverse long-term outcome and 2 late deaths were from pulmonary complications. Twenty-nine of 43 newborns (67%) with isolated CDH survived. The principal determinant of survival was pulmonary hypoplasia. Eighty-seven percent of survivors have associated morbidity including ongoing pulmonary, nutritional and neuro-developmental problems. Nevertheless preoperative stabilization and delayed surgery have been a satisfactory mode of management.

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Section: Discussionmentioning

confidence: 57%

“…The last child with GER gained weight after fundoplication. The incidence of GER in CDH survivors ranges from 12 to 69% [29,30]. Seven newborns developed GER soon after the repair of CDH but only one required surgery.…”

Section: Discussionmentioning

confidence: 97%

The immediate and long-term outcomes of newborns with congenital diaphragmatic hernia

et al. 2006

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“…Firstly, it has been suggested that elevated intraabdominal pressure, resulting from positioning the hernial contents into the abdominal cavity, in combination with reduced intra-thoracic pressure, increases the abdominalthoracic pressure gradient, which could predispose to GERD [93,94].…”

Section: Gastro-intestinal Morbiditymentioning

confidence: 99%

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

et al. 2008

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Congenital diaphragmatic hernia (CDH) is a life-threatening anomaly with a mortality rate of approximately 40-50%, depending on case selection. It has been suggested that new therapeutic modalities such as nitric oxide (NO), high frequency oxygenation (HFO) and extracorporal membrane oxygenation (ECMO) might decrease mortality associated with pulmonary hypertension and the sequelae of artificial ventilation. When these new therapies indeed prove to be beneficial, a larger number of children with severe forms of CDH might survive, resulting in an increase of CDH-associated complications and/or consequences. In follow-up studies of infants born with CDH, many complications including pulmonary damage, cardiovascular disease, gastro-intestinal disease, failure to thrive, neurocognitive defects and musculoskeletal abnormalities have been described. Long-term pulmonary morbidity in CDH consists of obstructive and restrictive lung function impairments due to altered lung structure and prolonged ventilatory support. CDH has also been associated with persistent pulmonary vascular abnormalities, resulting in pulmonary hypertension in the neonatal period.

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“…These data lead us to think of the additional antireflux surgery at the first operation for CDH. The same concept had been postulated since early 1990s [4], but is still controversial. The multicenter retrospective study conducted by French group showed a significant relationship between prophylactic fundoplication performed during initial diaphragmatic repair and survival without disordered growth [17].…”

Section: Discussionmentioning

confidence: 88%

“…Surgical approaches are reserved for children who have intractable symptoms or who are at risk for life-threatening complications of GERD [3]. Historically, the risk of GERD in CDH is thought to have increased with improvement of the survival of severe CDH [4,5]. Need for patch is one of risk factors of severe GERD which needs interventions [6][7][8][9], however, some have reported negative [10] or converse data [11] in pathological GERD.…”

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confidence: 96%

Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

et al. 2014

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Gastroesophageal reflux occurring after repair of congenital diaphragmatic hernia

Cited by 69 publications

References 15 publications

The immediate and long-term outcomes of newborns with congenital diaphragmatic hernia

The immediate and long-term outcomes of newborns with congenital diaphragmatic hernia

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

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