Gastrointestinal absorption of cadmium in mice during gestation and lactation I. Short-term exposure studies*1, *2

Bhattacharyya, Maryka H.; Whelton, Bartlett D.; Peterson, D.P.

doi:10.1016/0041-008x(81)90354-9

Cited by 35 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar phenomenon was observed in mice where systemic availability was higher (0.60%) in lactating mice, with a peak in the middle of the lactation period, as compared to nonlactating or nonpregnant mice (0.26%) (Bhattacharyya et al, 1981).…”

Section: Toxicokinetics Of Cadmium In Ewessupporting

confidence: 70%

“…This proliferation during lactation is accom- HOUPERT, FEDERSPIEL, AND MILHAUD panied by an increased absorption of calcium, iron, and lead (Halloran and De Luca, 1980;Batey andGallagher, 1977, Kostial andMomcilovic, 1972). It is possible that an increase in the gastrointestinal absorption of cadmium may also occur, as it does for calcium and iron (Bhattacharyya et al, 1981(Bhattacharyya et al, , 1982.…”

Section: Toxicokinetics Of Cadmium In Ewesmentioning

confidence: 98%

See 1 more Smart Citation

Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Houpert

Federspiel

Milhaud

1997

Environmental Research

View full text Add to dashboard Cite

Section: Toxicokinetics Of Cadmium In Ewessupporting

confidence: 70%

Section: Toxicokinetics Of Cadmium In Ewesmentioning

confidence: 98%

Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Houpert

Federspiel

Milhaud

1997

Environmental Research

View full text Add to dashboard Cite

“…High exposure to a foreign chemical, combined with rapid metabolic activation and slow conjugation, should put an individual at a high risk of developing cancer. Pregnant and lactating female animals absorb and retain substantially more dietary cadmium than their nonpregnant counterparts [48][49][50][51][52]. The present study demonstrated that in utero and lactational exposure to lead and cadmium alone and in combination decreased the activities of phase I enzymes metabolizing xenobiotics and endogenous steroids in both male and female PND 56 rats, but among the two metals, cadmium showed more inhibitory effect than lead and a similar trend was observed for both male and female rats.…”

Section: Discussionsupporting

confidence: 86%

Sex‐specific effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic/steroid‐metabolizing enzymes and antioxidant status

Pillai

Patel

Pandya

et al. 2009

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Liver has evolved complex enzymatic mechanisms to detoxify a wide array of xenobiotic substances, ranging from dietary components to environmental toxins to pharmaceuticals. Activities of many steroid-metabolizing enzymes in adult rat liver microsomes are sexually differentiated. Toxic effects of lead and cadmium on hepatic tissue have been well established in our earlier studies. We thus monitored the effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic- and steroid-metabolizing enzyme activities in both male and female F1 generation postnatal day (PND) 56 rats. Adult pregnant female rats were treated subcutaneously [0.05 mg/(kg body wt. day)] with sodium acetate (control group), lead acetate, and cadmium acetate separately and in combination throughout the gestational and lactational period. Hepatic phase I xenobiotic-metabolizing enzymes (NADPH- and NADH-cytochrome c reductase) activities significantly decreased significantly in all the metal-treated groups in both PND 56 male and female rats as compared with the control group. Hepatic phase II enzymes (uridine diphosphate-glucuronosyl transferase, gamma-glutamyl transpeptidase, glutathione-S-transferase, 17-beta-hydroxysteroid oxidoreductase) were also highly susceptible to all the metal-treated groups. The observed alterations in the oxidative stress and biochemical parameters in the liver of F1 generation male and female rats resulted from an independent effect of lead and/or cadmium and also from their interaction. Results suggest that early developmental exposure to lead and cadmium both alone and in combination can suppress the hepatic xenobiotic-metabolizing enzyme activities in the liver of F1 generation male and female rats in a sex-dependent manner.

show abstract

“…However, in both age groups DTPA caused a higher reduction of cadmium retention in the liver than in the kidney. This is in agreement with some previous results (32). However, in different experimental conditions (chronic subcutaneous cadmium administration) it was found that DTPA removed cadmium only from the kidney and testes without affecting liver retention (33).…”

Section: Effect Of Various Foods On Cadmium Retention and Distributionsupporting

confidence: 82%

Effect of Age and Diet on Renal Cadmium Retention in Rats

Kostial¹

1984

Environmental Health Perspectives

View full text Add to dashboard Cite

The results of our previous and recent work on cadmium metabolism in relation to age and diet are presented. Experiments were performed on albino rats aged 1-26 weeks. In some experiments rats were given different foods (milk, meat, bread) instead of standard rat diet. Some animals received trisodium calcium salt of diethylenetriaminepentaacetate (DTPA) intraperitoneally to decrease cadmium retention. Radioactive cadmium (ll5mCd) was administered orally and intraperitoneally. Whole body (WB), carcass (C) and organ (kidney, liver and brain) retentions were determined 1 and 2 weeks after a single radioisotope administration. The results are expressed as percentages of the administered dose (% D) and as percentages of whole body (% WB) and carcass (% C) radioactivities.After oral administration whole-body cadmium retention was higher in sucklings than in weaned animals, primarily due to increased gut retention. The kidney retention of orally administered cadmium was about 5-7 times higher in sucklings than in older rats. Cadmium distribution (% C) was similar after oral and intraperitoneal administration. In sucklings, kidney retention made a lower fraction of the carcass radioactivity one week after ll5mCd administration but reached adult values a week later. Liver retention in sucklings was a slightly lower fraction of the carcass radioactivity than in older rats at both time intervals. Brain retention (% C) was about 10 times higher in sucklings than in older rats throughout the experiment.Preliminary data on the influence of dietary treatments and treatment with DTPA indicate that some treatments which influence cadmium retention also influence cadmium distribution. Our results confirm previous findings that sucklings are at a higher risk than adults at the same level of enviroumental exposure to cadmium.

show abstract

Gastrointestinal absorption of cadmium in mice during gestation and lactation I. Short-term exposure studies1, 2

Cited by 35 publications

References 19 publications

Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Sex‐specific effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic/steroid‐metabolizing enzymes and antioxidant status

Effect of Age and Diet on Renal Cadmium Retention in Rats

Contact Info

Product

Resources

About