Gastrointestinal Absorption of Griseofulvin From Corn Oil-in-Water Emulsions

Bates, Theodore R.

doi:10.1001/archderm.1977.01640030048006

Cited by 16 publications

(2 citation statements)

References 13 publications

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“…For the same ratio of emulsified lipids ingested with griseofulvin in man, it was shown that the bioavailability was better when the amount of lipids ingested was higher (Bates et al 1977).…”

Section: Influence Of the Formulation On Absorption Of Griseofulvinmentioning

confidence: 98%

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

et al. 2008

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The effect of oil-in-water submicron emulsion (SE) droplet surface charge on absolute bioavailability of a poorly watersoluble drug (griseofulvin, as model drug) after oral administration was studied in conscious rat. Positively, negatively, and neutrally charged SE were designed and characterized (size, polydispersity index, zeta potential, and pH). Three emulsion formulations, whose compositions included 40% oil phase and differed only in the nature of the emulsifying agent, were retained. Only the positively charged SE showed a higher area under the plasma concentrationtime curve (AUC 0→∞ ) in comparison with the tablet and with the other SE.

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Section: Influence Of the Formulation On Absorption Of Griseofulvinmentioning

confidence: 98%

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

et al. 2008

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“…pH48) should be justified 31,30 . In order to simulate intestinal fluid or gastric fluid, dissolution medium of pH 6.8 or pH 1.2 are encouraged, respectively 51 .…”

Section: Biorelevant Mediamentioning

confidence: 99%

In vitro–in vivocorrelations: general concepts, methodologies and regulatory applications

González‐García

Mangas‐Sanjuán

Merino-Sanjuán

et al. 2015

Drug Development and Industrial Pharmacy

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The major objective of in vitro-in vivo correlations is to be able to use in vitro data to predict in vivo performance serving as a surrogate for an in vivo bioavailability test and to support biowaivers. Therefore, the aims of this review are: (i) to clarify the factors involved during bio-predictive dissolution method development; and (ii) the elements that may affect the mathematical analysis in order to exploit all information available. This article covers the basic aspects of dissolution media and apparatus used in the development of in vivo predictive dissolution methods, including the latest proposals in this field as well as the summary of the mathematical methods for establishing the in vitro-in vivo relationship and their scope and limitations. The incorporation of physiological relevant factors in the in vitro dissolution method is essential to get accurate in vivo predictions. Standard quality control dissolution methods do not necessarily reflect the in vivo behavior, so they rarely are useful for predicting in vivo performance. The combination of physiological based dissolution methods with physiological-based pharmacokinetics models incorporating gastrointestinal variables will lead to robust tools for drug and formulation development, nevertheless their regulatory use for biowaiver application still require harmonization of the mathematical methods proposed and more detailed recommendations about the procedures for setting up dissolution specifications.

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